Sebastien burel
Sebastien burel
Ionis pharmaceuticals
Verified email at ionisph.com
Title
Cited by
Cited by
Year
AML1-ETO expression is directly involved in the development of acute myeloid leukemia in the presence of additional mutations
Y Yuan, L Zhou, T Miyamoto, H Iwasaki, N Harakawa, CJ Hetherington, ...
Proceedings of the National Academy of Sciences 98 (18), 10398-10403, 2001
4912001
Dichotomy of AML1-ETO functions: growth arrest versus block of differentiation
SA Burel, N Harakawa, L Zhou, T Pabst, DG Tenen, DE Zhang
Molecular and cellular biology 21 (16), 5577-5590, 2001
1722001
Deletion of an AML1-ETO C-terminal NcoR/SMRT-interacting region strongly induces leukemia development
M Yan, SA Burel, LF Peterson, E Kanbe, H Iwasaki, A Boyapati, R Hines, ...
Proceedings of the National Academy of Sciences of the United States of …, 2004
1542004
Non-CpG-containing antisense 2′-methoxyethyl oligonucleotides activate a proinflammatory response independent of Toll-like receptor 9 or myeloid differentiation factor 88
JJ Senn, S Burel, SP Henry
Journal of Pharmacology and Experimental Therapeutics 314 (3), 972-979, 2005
1042005
Non-CpG Containing Antisense 2′ MOE Oligonucleotides Activate Response Independent of TLR9 or MyD88
JJ Senn, S Burel, SP Henry
104*2005
Hepatotoxicity of high affinity gapmer antisense oligonucleotides is mediated by RNase H1 dependent promiscuous reduction of very long pre-mRNA transcripts
SA Burel, CE Hart, P Cauntay, J Hsiao, T Machemer, M Katz, A Watt, ...
Nucleic acids research 44 (5), 2093-2109, 2015
1012015
Comprehensive Structure–Activity Relationship of Triantennary N-Acetylgalactosamine Conjugated Antisense Oligonucleotides for Targeted Delivery to Hepatocytes
TP Prakash, J Yu, MT Migawa, GA Kinberger, WB Wan, ME Østergaard, ...
Journal of medicinal chemistry 59 (6), 2718-2733, 2016
832016
Preclinical evaluation of the toxicological effects of a novel constrained ethyl modified antisense compound targeting signal transducer and activator of transcription 3 in …
SA Burel, SR Han, HS Lee, DA Norris, BS Lee, T Machemer, SY Park, ...
Nucleic acid therapeutics 23 (3), 213-227, 2013
702013
Integrated safety assessment of 2′-O-methoxyethyl chimeric antisense oligonucleotides in nonhuman primates and healthy human volunteers
ST Crooke, BF Baker, TJ Kwoh, W Cheng, DJ Schulz, S Xia, N Salgado, ...
Molecular Therapy 24 (10), 1771-1782, 2016
632016
Unique O-methoxyethyl ribose-DNA chimeric oligonucleotide induces an atypical melanoma differentiation-associated gene 5-dependent induction of type I interferon response
SA Burel, T Machemer, FL Ragone, H Kato, P Cauntay, S Greenlee, ...
Journal of Pharmacology and Experimental Therapeutics 342 (1), 150-162, 2012
232012
Investigation into the mechanism (s) that leads to platelet decreases in cynomolgus monkeys during administration of ISIS-104838, a 2ʹ-MOE-modified antisense oligonucleotide
PK Narayanan, L Shen, BR Curtis, M Bourdon, JP Nolan, F Zhou, ...
Toxicological Sciences, 2018
172018
Assessment of the Effects of 2′-Methoxyethyl Antisense Oligonucleotides on Platelet Count in Cynomolgus Nonhuman Primates
SP Henry, P Narayanan, L Shen, S Bhanot, HS Younis, SA Burel
nucleic acid therapeutics 27 (4), 197-208, 2017
122017
The Distinct and Cooperative Roles of Toll-Like Receptor 9 and Receptor for Advanced Glycation End Products in Modulating In Vivo Inflammatory Responses to …
S Paz, J Hsiao, P Cauntay, A Soriano, L Bai, T Machemer, X Xiao, S Guo, ...
nucleic acid therapeutics 27 (5), 272-284, 2017
72017
AML1 and AML1 fusion protein AML1-ETO in myeloid gene regulation and leukemogenesis
DE Zhang, S Burel, L Zhou, CJ Hetherington, Y Yuan
Blood Cells, Molecules, and Diseases 27 (2), 368-376, 2001
42001
Unique moe-dna chimeric oligonucleotide induces an atypical mda5 dependent induction of type i interferon response
SA Burel, T Machemer, FL Ragone, H Kato, P Cauntay, S Greenlee, ...
J Pharmacol Exp Ther, 2012
22012
A UNIQUE MOE-DNA CHIMERIC OLIGONUCLEOTIDE INDUCES MDA-5 DEPENDENT INDUCTION OF TYPE I INTERFERON RESPONSE
SA Burel, H Sato, T Machemer, P Cauntay, SP Henry
NUCLEIC ACID THERAPEUTICS 21 (5), A4-A4, 2011
2011
INFLAMMATION AND IMMUNOPHARMACOLOGY-Non-CpG-Containing Antisense 2'-Methoxyethyl Oligonucleotides Activate a Proinflammatory Response Independent of Toll-Like Receptor 9 or …
JJ Senn, S Burel, SP Henry
Journal of Pharmacology and Experimental Therapeutics 314 (3), 972-979, 2005
2005
When less is more: Truncation of AML1-ETO (RUNX1-MTG8) fusion protein results in a rapid onset of acute myeloid leukemia.
S Burel, M Yan, L Peterson, H Iwasaki, R Hines, E Kanbe, A Boyapati, ...
BLOOD 102 (11), 585A-585A, 2003
2003
AML1/ETO impairs the interferon gamma transcriptional response.
K Sasaki, S Burel, DE Zhang, TR Golub
BLOOD 98 (11), 456A-456A, 2001
2001
Dichotomy of AML1-ETO function: Apoptosis versus block of differentiation.
S Burel, N Harakawa, LM Zhou, DE Zhang
BLOOD 96 (11), 90A-90A, 2000
2000
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