Takip et
Kevin Kauffman
Kevin Kauffman
Associate Director, Orna Therapeutics
mit.edu üzerinde doğrulanmış e-posta adresine sahip
Başlık
Alıntı yapanlar
Alıntı yapanlar
Yıl
Optimization of lipid nanoparticle formulations for mRNA delivery in vivo with fractional factorial and definitive screening designs
KJ Kauffman, JR Dorkin, JH Yang, MW Heartlein, F DeRosa, FF Mir, ...
Nano letters 15 (11), 7300-7306, 2015
5822015
Delivery technologies for genome editing
H Yin, KJ Kauffman, DG Anderson
Nature reviews Drug discovery 16 (6), 387-399, 2017
5572017
Structure-guided chemical modification of guide RNA enables potent non-viral in vivo genome editing
H Yin, CQ Song, S Suresh, Q Wu, S Walsh, LH Rhym, E Mintzer, ...
Nature biotechnology 35 (12), 1179-1187, 2017
4632017
Materials for non-viral intracellular delivery of messenger RNA therapeutics
KJ Kauffman, MJ Webber, DG Anderson
Journal of Controlled Release 240, 227-234, 2016
3572016
Polymer–lipid nanoparticles for systemic delivery of mRNA to the lungs
JC Kaczmarek, AK Patel, KJ Kauffman, OS Fenton, MJ Webber, ...
Angewandte Chemie 128 (44), 14012-14016, 2016
2842016
Inhaled nanoformulated mRNA polyplexes for protein production in lung epithelium
AK Patel, JC Kaczmarek, S Bose, KJ Kauffman, F Mir, MW Heartlein, ...
Advanced Materials 31 (8), 1805116, 2019
2752019
Barcoded nanoparticles for high throughput in vivo discovery of targeted therapeutics
JE Dahlman, KJ Kauffman, Y Xing, TE Shaw, FF Mir, CC Dlott, R Langer, ...
Proceedings of the National Academy of Sciences 114 (8), 2060-2065, 2017
2232017
Bioinspired alkenyl amino alcohol ionizable lipid materials for highly potent in vivo mRNA delivery
OS Fenton, KJ Kauffman, RL McClellan, EA Appel, JR Dorkin, MW Tibbitt, ...
Advanced materials (Deerfield Beach, Fla.) 28 (15), 2939, 2016
2082016
Endothelial TGF-β signalling drives vascular inflammation and atherosclerosis
PY Chen, L Qin, G Li, Z Wang, JE Dahlman, J Malagon-Lopez, S Gujja, ...
Nature metabolism 1 (9), 912-926, 2019
1962019
Synthesis and biological evaluation of ionizable lipid materials for the in vivo delivery of messenger RNA to B lymphocytes
OS Fenton, KJ Kauffman, JC Kaczmarek, RL McClellan, S Jhunjhunwala, ...
Advanced Materials 29 (33), 1606944, 2017
1902017
RNAi targeting multiple cell adhesion molecules reduces immune cell recruitment and vascular inflammation after myocardial infarction
HB Sager, P Dutta, JE Dahlman, M Hulsmans, G Courties, Y Sun, T Heidt, ...
Science translational medicine 8 (342), 342ra80-342ra80, 2016
1852016
Efficacy and immunogenicity of unmodified and pseudouridine-modified mRNA delivered systemically with lipid nanoparticles in vivo
KJ Kauffman, FF Mir, S Jhunjhunwala, JC Kaczmarek, JE Hurtado, ...
Biomaterials 109, 78-87, 2016
1732016
Optimization of a degradable polymer–lipid nanoparticle for potent systemic delivery of mRNA to the lung endothelium and immune cells
JC Kaczmarek, KJ Kauffman, OS Fenton, K Sadtler, AK Patel, ...
Nano letters 18 (10), 6449-6454, 2018
1642018
Therapeutic efficacy in a hemophilia B model using a biosynthetic mRNA liver depot system
F DeRosa, B Guild, S Karve, L Smith, K Love, JR Dorkin, KJ Kauffman, ...
Gene therapy 23 (10), 699-707, 2016
1532016
Uremic toxin indoxyl sulfate promotes proinflammatory macrophage activation via the interplay of OATP2B1 and Dll4-Notch signaling: Potential mechanism for accelerated …
T Nakano, S Katsuki, M Chen, JL Decano, A Halu, LH Lee, DVS Pestana, ...
Circulation 139 (1), 78-96, 2019
1472019
Synthesis and characterization of acetalated dextran polymer and microparticles with ethanol as a degradation product
KJ Kauffman, C Do, S Sharma, MD Gallovic, EM Bachelder, KM Ainslie
ACS applied materials & interfaces 4 (8), 4149-4155, 2012
992012
Cell-cycle-targeting MicroRNAs as therapeutic tools against refractory cancers
P Hydbring, Y Wang, A Fassl, X Li, V Matia, T Otto, YJ Choi, KE Sweeney, ...
Cancer cell 31 (4), 576-590. e8, 2017
952017
Synthesis, optimization, and characterization of camptothecin-loaded acetalated dextran porous microparticles for pulmonary delivery
SA Meenach, YJ Kim, KJ Kauffman, N Kanthamneni, EM Bachelder, ...
Molecular pharmaceutics 9 (2), 290-298, 2012
852012
Rapid, single-cell analysis and discovery of vectored mRNA transfection in vivo with a loxP-flanked tdTomato reporter mouse
KJ Kauffman, MA Oberli, JR Dorkin, JE Hurtado, JC Kaczmarek, ...
Molecular therapy-Nucleic acids 10, 55-63, 2018
782018
Optimization of rapamycin-loaded acetalated dextran microparticles for immunosuppression
KJ Kauffman, N Kanthamneni, SA Meenach, BC Pierson, EM Bachelder, ...
International journal of pharmaceutics 422 (1-2), 356-363, 2012
782012
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