Senthil K Muthuswamy
Senthil K Muthuswamy
BIDMC, Harvard Medical School
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Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures
J Debnath, SK Muthuswamy, JS Brugge
Methods 30 (3), 256-268, 2003
The role of apoptosis in creating and maintaining luminal space within normal and oncogene-expressing mammary acini
J Debnath, KR Mills, NL Collins, MJ Reginato, SK Muthuswamy, ...
Cell 111 (1), 29-40, 2002
Epidermal growth factor receptor (HER1) tyrosine kinase inhibitor ZD1839 (Iressa) inhibits HER2/neu (erbB2)-overexpressing breast cancer cells in vitro and in vivo
SL Moulder, FM Yakes, SK Muthuswamy, R Bianco, JF Simpson, ...
Cancer research 61 (24), 8887-8895, 2001
ErbB2, but not ErbB1, reinitiates proliferation and induces luminal repopulation in epithelial acini
SK Muthuswamy, D Li, S Lelievre, MJ Bissell, JS Brugge
Nature cell biology 3 (9), 785-792, 2001
Integrins and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikis
MJ Reginato, KR Mills, JK Paulus, DK Lynch, DC Sgroi, J Debnath, ...
Nature cell biology 5 (8), 733-740, 2003
HER2 kinase domain mutation results in constitutive phosphorylation and activation of HER2 and EGFR and resistance to EGFR tyrosine kinase inhibitors
SE Wang, A Narasanna, M Perez-Torres, B Xiang, FY Wu, S Yang, ...
Cancer cell 10 (1), 25-38, 2006
Deregulation of scribble promotes mammary tumorigenesis and reveals a role for cell polarity in carcinoma
L Zhan, A Rosenberg, KC Bergami, M Yu, Z Xuan, AB Jaffe, C Allred, ...
Cell 135 (5), 865-878, 2008
Controlled dimerization of ErbB receptors provides evidence for differential signaling by homo-and heterodimers
SK Muthuswamy, M Gilman, JS Brugge
Molecular and cellular biology 19 (10), 6845-6857, 1999
Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell–and patient-derived tumor organoids
L Huang, A Holtzinger, I Jagan, M BeGora, I Lohse, N Ngai, C Nostro, ...
Nature medicine 21 (11), 1364-1371, 2015
The splicing factor SRSF1 regulates apoptosis and proliferation to promote mammary epithelial cell transformation
O Anczuków, AZ Rosenberg, M Akerman, S Das, L Zhan, R Karni, ...
Nature structural & molecular biology 19 (2), 220, 2012
Par6–aPKC uncouples ErbB2 induced disruption of polarized epithelial organization from proliferation control
V Aranda, T Haire, ME Nolan, JP Calarco, AZ Rosenberg, JP Fawcett, ...
Nature cell biology 8 (11), 1235-1245, 2006
Mammary tumors expressing the neu proto-oncogene possess elevated c-Src tyrosine kinase activity.
SK Muthuswamy, PM Siegel, DL Dankort, MA Webster, WJ Muller
Molecular and cellular biology 14 (1), 735-743, 1994
Cooperation of the ErbB2 receptor and transforming growth factor β in induction of migration and invasion in mammary epithelial cells
SE Seton-Rogers, Y Lu, LM Hines, M Koundinya, J LaBaer, ...
Proceedings of the National Academy of Sciences 101 (5), 1257-1262, 2004
Activation of the c-Src tyrosine kinase is required for the induction of mammary tumors in transgenic mice.
CT Guy, SK Muthuswamy, RD Cardiff, P Soriano, WJ Muller
Genes & development 8 (1), 23-32, 1994
A role for microRNAs in maintenance of mouse mammary epithelial progenitor cells
I Ibarra, Y Erlich, SK Muthuswamy, R Sachidanandam, GJ Hannon
Genes & development 21 (24), 3238-3243, 2007
Requirement for both Shc and phosphatidylinositol 3′ kinase signaling pathways in polyomavirus middle T-mediated mammary tumorigenesis
MA Webster, JN Hutchinson, MJ Rauh, SK Muthuswamy, M Anton, ...
Molecular and Cellular Biology 18 (4), 2344-2359, 1998
Targeting the disordered C terminus of PTP1B with an allosteric inhibitor
N Krishnan, D Koveal, DH Miller, B Xue, SD Akshinthala, J Kragelj, ...
Nature chemical biology 10 (7), 558-566, 2014
Epidermal growth factor receptor-dependent regulation of integrin-mediated signaling and cell cycle entry in epithelial cells
HM Bill, B Knudsen, SL Moores, SK Muthuswamy, VR Rao, JS Brugge, ...
Molecular and cellular biology 24 (19), 8586-8599, 2004
ΔNp63α is an oncogene that targets chromatin remodeler Lsh to drive skin stem cell proliferation and tumorigenesis
WM Keyes, M Pecoraro, V Aranda, E Vernersson-Lindahl, W Li, H Vogel, ...
Cell stem cell 8 (2), 164-176, 2011
Bim regulation of lumen formation in cultured mammary epithelial acini is targeted by oncogenes
MJ Reginato, KR Mills, EBE Becker, DK Lynch, A Bonni, SK Muthuswamy, ...
Molecular and cellular biology 25 (11), 4591-4601, 2005
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