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Stephen Frye
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Year
Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases
W Xu, H Yang, Y Liu, Y Yang, P Wang, SH Kim, S Ito, C Yang, P Wang, ...
Cancer cell 19 (1), 17-30, 2011
30112011
The promise and peril of chemical probes
CH Arrowsmith, JE Audia, C Austin, J Baell, J Bennett, J Blagg, C Bountra, ...
Nature chemical biology 11 (8), 536-541, 2015
8332015
Dynamic reprogramming of the kinome in response to targeted MEK inhibition in triple-negative breast cancer
JS Duncan, MC Whittle, K Nakamura, AN Abell, AA Midland, ...
Cell 149 (2), 307-321, 2012
8282012
A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells
M Vedadi, D Barsyte-Lovejoy, F Liu, S Rival-Gervier, A Allali-Hassani, ...
Nature chemical biology 7 (8), 566-574, 2011
5472011
An orally bioavailable chemical probe of the lysine methyltransferases EZH2 and EZH1
KD Konze, A Ma, F Li, D Barsyte-Lovejoy, T Parton, CJ MacNevin, F Liu, ...
ACS chemical biology 8 (6), 1324-1334, 2013
4802013
The art of the chemical probe
SV Frye
Nature chemical biology 6 (3), 159-161, 2010
4432010
Too many roads not taken
AM Edwards, R Isserlin, GD Bader, SV Frye, TM Willson, FH Yu
Nature 470 (7333), 163-165, 2011
4342011
Discovery of β-arrestin–biased dopamine D2 ligands for probing signal transduction pathways essential for antipsychotic efficacy
JA Allen, JM Yost, V Setola, X Chen, MF Sassano, M Chen, S Peterson, ...
Proceedings of the National Academy of Sciences 108 (45), 18488-18493, 2011
3802011
Oxindole-based inhibitors of cyclin-dependent kinase 2 (CDK2): design, synthesis, enzymatic activities, and X-ray crystallographic analysis
HN Bramson, J Corona, ST Davis, SH Dickerson, M Edelstein, SV Frye, ...
Journal of medicinal chemistry 44 (25), 4339-4358, 2001
3172001
The discovery of potent cRaf1 kinase inhibitors
K Lackey, M Cory, R Davis, SV Frye, PA Harris, RN Hunter, DK Jung, ...
Bioorganic & medicinal chemistry letters 10 (3), 223-226, 2000
2932000
Discovery of an in vivo chemical probe of the lysine methyltransferases G9a and GLP
F Liu, D Barsyte-Lovejoy, F Li, Y Xiong, V Korboukh, XP Huang, ...
Journal of medicinal chemistry 56 (21), 8931-8942, 2013
2642013
Structure and inhibition of microbiome β-glucuronidases essential to the alleviation of cancer drug toxicity
BD Wallace, AB Roberts, RM Pollet, JD Ingle, KA Biernat, SJ Pellock, ...
Chemistry & biology 22 (9), 1238-1249, 2015
2492015
Discovery of a 2, 4-diamino-7-aminoalkoxyquinazoline as a potent and selective inhibitor of histone lysine methyltransferase G9a
F Liu, X Chen, A Allali-Hassani, AM Quinn, GA Wasney, A Dong, ...
Journal of medicinal chemistry 52 (24), 7950-7953, 2009
2462009
Prevention of chemotherapy-induced alopecia in rats by CDK inhibitors
ST Davis, BG Benson, HN Bramson, DE Chapman, SH Dickerson, ...
Science 291 (5501), 134-137, 2001
2452001
Selective inhibition of EZH2 and EZH1 enzymatic activity by a small molecule suppresses MLL-rearranged leukemia
B Xu, DM On, A Ma, T Parton, KD Konze, SG Pattenden, DF Allison, L Cai, ...
Blood, The Journal of the American Society of Hematology 125 (2), 346-357, 2015
2342015
Protein lysine methyltransferase G9a inhibitors: design, synthesis, and structure activity relationships of 2, 4-diamino-7-aminoalkoxy-quinazolines.
F Liu, X Chen, A Allali-Hassani, AM Quinn, TJ Wigle, GA Wasney, A Dong, ...
Journal of medicinal chemistry 53 (15), 5844-5857, 2010
2182010
Unique preclinical characteristics of GG745, a potent dual inhibitor of 5AR
HN Bramson, D Hermann, KW Batchelor, FW Lee, MK James, SV Frye
Journal of Pharmacology and Experimental Therapeutics 282 (3), 1496-1502, 1997
2031997
Chelates as intermediates in nucleophilic additions to alkoxy ketones according to Cram's rule (cyclic model)
X Chen, ER Hortelano, EL Eliel, SV Frye
Journal of the American Chemical Society 114 (5), 1778-1784, 1992
1941992
Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain
LI James, D Barsyte-Lovejoy, N Zhong, L Krichevsky, VK Korboukh, ...
Nature chemical biology 9 (3), 184-191, 2013
1882013
Optimization of cellular activity of G9a inhibitors 7-aminoalkoxy-quinazolines
F Liu, D Barsyte-Lovejoy, A Allali-Hassani, Y He, JM Herold, X Chen, ...
Journal of medicinal chemistry 54 (17), 6139-6150, 2011
1622011
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