Ganesh M Shankar
Ganesh M Shankar
Verified email at partners.org
Title
Cited by
Cited by
Year
Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory
GM Shankar, S Li, TH Mehta, A Garcia-Munoz, NE Shepardson, I Smith, ...
Nature medicine 14 (8), 837-842, 2008
36672008
Natural oligomers of the amyloid-β protein specifically disrupt cognitive function
JP Cleary, DM Walsh, JJ Hofmeister, GM Shankar, MA Kuskowski, ...
Nature neuroscience 8 (1), 79-84, 2005
19962005
Natural oligomers of the Alzheimer amyloid-β protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway
GM Shankar, BL Bloodgood, M Townsend, DM Walsh, DJ Selkoe, ...
Journal of Neuroscience 27 (11), 2866-2875, 2007
17112007
Soluble oligomers of amyloid β protein facilitate hippocampal long-term depression by disrupting neuronal glutamate uptake
S Li, S Hong, NE Shepardson, DM Walsh, GM Shankar, D Selkoe
Neuron 62 (6), 788-801, 2009
9282009
Effects of secreted oligomers of amyloid β‐protein on hippocampal synaptic plasticity: a potent role for trimers
M Townsend, GM Shankar, T Mehta, DM Walsh, DJ Selkoe
The Journal of physiology 572 (2), 477-492, 2006
7222006
Amyloid β protein immunotherapy neutralizes Aβ oligomers that disrupt synaptic plasticity in vivo
I Klyubin, DM Walsh, CA Lemere, WK Cullen, GM Shankar, V Betts, ...
Nature medicine 11 (5), 556-561, 2005
6242005
Soluble Aβ oligomers inhibit long-term potentiation through a mechanism involving excessive activation of extrasynaptic NR2B-containing NMDA receptors
S Li, M Jin, T Koeglsperger, NE Shepardson, GM Shankar, DJ Selkoe
Journal of Neuroscience 31 (18), 6627-6638, 2011
5862011
Protein aggregation in the brain: the molecular basis for Alzheimer’s and Parkinson’s diseases
GB Irvine, OM El-Agnaf, GM Shankar, DM Walsh
Molecular medicine 14 (7), 451-464, 2008
5802008
Alzheimer's disease: synaptic dysfunction and Aβ
GM Shankar, DM Walsh
Molecular neurodegeneration 4 (1), 1-13, 2009
5002009
Choline acetyltransferase: the structure, distribution and pathologic changes in the central nervous system
Y Oda
Pathology international 49 (11), 921-937, 1999
4431999
Certain inhibitors of synthetic amyloid β-peptide (Aβ) fibrillogenesis block oligomerization of natural Aβ and thereby rescue long-term potentiation
DM Walsh, M Townsend, MB Podlisny, GM Shankar, JV Fadeeva, ...
Journal of Neuroscience 25 (10), 2455-2462, 2005
3692005
The role of cell-derived oligomers of Aβ in Alzheimer's disease and avenues for therapeutic intervention
DM Walsh, I Klyubin, GM Shankar, M Townsend, JV Fadeeva, V Betts, ...
Biochemical Society Transactions 33 (5), 1087-1090, 2005
2822005
The presence of sodium dodecyl sulphate-stable Aβ dimers is strongly associated with Alzheimer-type dementia
JM Mc Donald, GM Savva, C Brayne, AT Welzel, G Forster, GM Shankar, ...
Brain 133 (5), 1328-1341, 2010
2772010
Cholesterol level and statin use in Alzheimer disease: I. Review of epidemiological and preclinical studies
NE Shepardson, GM Shankar, DJ Selkoe
Archives of neurology 68 (10), 1239-1244, 2011
2252011
A specific enzyme-linked immunosorbent assay for measuring β-amyloid protein oligomers in human plasma and brain tissue of patients with Alzheimer disease
W Xia, T Yang, G Shankar, IM Smith, Y Shen, DM Walsh, DJ Selkoe
Archives of neurology 66 (2), 190-199, 2009
2212009
Cholesterol level and statin use in Alzheimer disease: II. Review of human trials and recommendations
NE Shepardson, GM Shankar, DJ Selkoe
Archives of neurology 68 (11), 1385-1392, 2011
1862011
Loss of neprilysin function promotes amyloid plaque formation and causes cerebral amyloid angiopathy
W Farris, SG Schütz, JR Cirrito, GM Shankar, X Sun, A George, ...
The American journal of pathology 171 (1), 241-251, 2007
1812007
Dramatic response of BRAF V600E mutant papillary craniopharyngioma to targeted therapy
PK Brastianos, GM Shankar, CM Gill, A Taylor-Weiner, N Nayyar, ...
JNCI: Journal of the National Cancer Institute 108 (2), 2016
1572016
Complement component C3 and complement receptor type 3 contribute to the phagocytosis and clearance of fibrillar Aβ by microglia
H Fu, B Liu, JL Frost, S Hong, M Jin, B Ostaszewski, GM Shankar, ...
Glia 60 (6), 993-1003, 2012
1342012
Biochemical and immunohistochemical analysis of an Alzheimer's disease mouse model reveals the presence of multiple cerebral Aβ assembly forms throughout life
GM Shankar, MA Leissring, A Adame, X Sun, E Spooner, E Masliah, ...
Neurobiology of disease 36 (2), 293-302, 2009
1282009
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Articles 1–20