| Top-down quantitative proteomics identified phosphorylation of cardiac troponin I as a candidate biomarker for chronic heart failure J Zhang, MJ Guy, HS Norman, YC Chen, Q Xu, X Dong, H Guner, S Wang, ... Journal of proteome research 10 (9), 4054-4065, 2011 | 215 | 2011 |
| Forging isopeptide bonds using thiol–ene chemistry: site-specific coupling of ubiquitin molecules for studying the activity of isopeptidases EM Valkevich, RG Guenette, NA Sanchez, Y Chen, Y Ge, ER Strieter Journal of the American Chemical Society 134 (16), 6916-6919, 2012 | 146 | 2012 |
| Augmented phosphorylation of cardiac troponin I in hypertensive heart failure X Dong, CA Sumandea, YC Chen, ML Garcia-Cazarin, J Zhang, ... Journal of Biological Chemistry 287 (2), 848-857, 2012 | 129 | 2012 |
| Top-down proteomics reveals concerted reductions in myofilament and Z-disc protein phosphorylation after acute myocardial infarction Y Peng, ZR Gregorich, SG Valeja, H Zhang, W Cai, YC Chen, H Guner, ... Molecular & Cellular Proteomics 13 (10), 2752-2764, 2014 | 116 | 2014 |
| Nonenzymatic polymerization of ubiquitin: single‐step synthesis and isolation of discrete ubiquitin oligomers VH Trang, EM Valkevich, S Minami, YC Chen, Y Ge, ER Strieter Angewandte Chemie International Edition 51 (52), 13085-13088, 2012 | 72 | 2012 |
| Design of a brain-penetrant CDK4/6 inhibitor for glioblastoma Bioorganic & Medicinal Chemistry Letters 29 (16), 2294-2301, 2019 | 44 | 2019 |
| Phosphorylation, but not alternative splicing or proteolytic degradation, is conserved in human and mouse cardiac troponin T J Zhang, H Zhang, S Ayaz-Guner, YC Chen, X Dong, Q Xu, Y Ge Biochemistry 50 (27), 6081-6092, 2011 | 43 | 2011 |
| Comprehensive analysis of tropomyosin isoforms in skeletal muscles by top-down proteomics Y Jin, Y Peng, Z Lin, YC Chen, L Wei, TA Hacker, L Larsson, Y Ge Journal of muscle research and cell motility 37, 41-52, 2016 | 35 | 2016 |
| Effective top-down LC/MS+ method for assessing actin isoforms as a potential cardiac disease marker YC Chen, S Ayaz-Guner, Y Peng, NM Lane, MR Locher, T Kohmoto, ... Analytical chemistry 87 (16), 8399-8406, 2015 | 32 | 2015 |
| An allosteric pan-TEAD inhibitor blocks oncogenic YAP/TAZ signaling and overcomes KRAS G12C inhibitor resistance TJ Hagenbeek, JR Zbieg, M Hafner, R Mroue, JA Lacap, NM Sodir, ... Nature Cancer 4 (6), 812-828, 2023 | 30 | 2023 |
| Improving confidence in the determination of free fraction for highly bound drugs using bidirectional equilibrium dialysis YC Chen, JR Kenny, M Wright, CECA Hop, Z Yan Journal of Pharmaceutical Sciences 108 (3), 1296-1302, 2019 | 29 | 2019 |
| The impact of antibody selection on the detection of cardiac troponin I MJ Guy, YC Chen, L Clinton, H Zhang, J Zhang, X Dong, Q Xu, ... Clinica Chimica Acta 420, 82-88, 2013 | 22 | 2013 |
| Changes in organic anion transporting polypeptide uptake in HEK293 overexpressing cells in the presence and absence of human plasma CM Bowman, E Chen, L Chen, YC Chen, X Liang, M Wright, Y Chen, ... Drug Metabolism and Disposition 48 (1), 18-24, 2020 | 20 | 2020 |
| Optimization of globomycin analogs as novel gram-negative antibiotics K Garland, H Pantua, MG Braun, DJ Burdick, GM Castanedo, YC Chen, ... Bioorganic & Medicinal Chemistry Letters 30 (20), 127419, 2020 | 16 | 2020 |
| Dissecting human skeletal muscle troponin proteoforms by top-down mass spectrometry YC Chen, MP Sumandea, L Larsson, RL Moss, Y Ge Journal of muscle research and cell motility 36, 169-181, 2015 | 11 | 2015 |
| Investigating the impact of albumin on the liver uptake of pitavastatin and warfarin in Nagase analbuminemic rats JH Chang, YC Chen, J Cheong, RS Jones, J Pang Drug Metabolism and Disposition 47 (11), 1307-1313, 2019 | 10 | 2019 |
| Evaluation of tissue binding in three tissues across five species and prediction of volume of distribution from plasma protein and tissue binding with an existing model F Hsu, YC Chen, F Broccatelli Drug Metabolism and Disposition 49 (4), 330-336, 2021 | 9 | 2021 |
| Unremarkable impact of Oatp inhibition on the liver concentration of fluvastatin, lovastatin and pitavastatin in wild-type and Oatp1a/1b knockout mouse JH Chang, X Zhang, K Messick, YC Chen, E Chen, J Cheong, J Ly Xenobiotica 49 (5), 602-610, 2019 | 7 | 2019 |
| Turning the Other Cheek: Influence of the cis-Tetrafluorocyclohexyl Motif on Physicochemical and Metabolic Properties Y Wang, W Lee, YC Chen, Y Zhou, E Plise, M Migliozzi, JJ Crawford ACS Medicinal Chemistry Letters 13 (9), 1517-1523, 2022 | 4 | 2022 |
| Lipid Tales: Optimizing Arylomycin Membrane Anchors MFT Koehler, YC Chen, Y Chen, Y Chen, JJ Crawford, MR Durk, ... ACS Medicinal Chemistry Letters 14 (11), 1524-1530, 2023 | 1 | 2023 |
