| CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity S Nishimura, I Manabe, M Nagasaki, K Eto, H Yamashita, M Ohsugi, ... Nature medicine 15 (8), 914-920, 2009 | 2543 | 2009 |
| Overexpression of monocyte chemoattractant protein-1 in adipose tissues causes macrophage recruitment and insulin resistance N Kamei, K Tobe, R Suzuki, M Ohsugi, T Watanabe, N Kubota, ... Journal of biological chemistry 281 (36), 26602-26614, 2006 | 1101 | 2006 |
| Saturated fatty acid and TLR signaling link β cell dysfunction and islet inflammation K Eguchi, I Manabe, Y Oishi-Tanaka, M Ohsugi, N Kono, F Ogata, N Yagi, ... Cell metabolism 15 (4), 518-533, 2012 | 560 | 2012 |
| Adipogenesis in obesity requires close interplay between differentiating adipocytes, stromal cells, and blood vessels S Nishimura, I Manabe, M Nagasaki, Y Hosoya, H Yamashita, H Fujita, ... Diabetes 56 (6), 1517-1526, 2007 | 542 | 2007 |
| Adiponectin enhances insulin sensitivity by increasing hepatic IRS-2 expression via a macrophage-derived IL-6-dependent pathway M Awazawa, K Ueki, K Inabe, T Yamauchi, N Kubota, K Kaneko, ... Cell metabolism 13 (4), 401-412, 2011 | 345 | 2011 |
| In vivo imaging in mice reveals local cell dynamics and inflammation in obese adipose tissue S Nishimura, I Manabe, M Nagasaki, K Seo, H Yamashita, Y Hosoya, ... The Journal of clinical investigation 118 (2), 710-721, 2008 | 341 | 2008 |
| Defective insulin secretion and increased susceptibility to experimental diabetes are induced by reduced Akt activity in pancreatic islet β cells E Bernal-Mizrachi, S Fatrai, JD Johnson, M Ohsugi, K Otani, Z Han, ... The Journal of clinical investigation 114 (7), 928-936, 2004 | 304 | 2004 |
| Dynamic functional relay between insulin receptor substrate 1 and 2 in hepatic insulin signaling during fasting and feeding N Kubota, T Kubota, S Itoh, H Kumagai, H Kozono, I Takamoto, ... Cell metabolism 8 (1), 49-64, 2008 | 274 | 2008 |
| Mice conditionally lacking the Wolfram gene in pancreatic islet beta cells exhibit diabetes as a result of enhanced endoplasmic reticulum stress and apoptosis AC Riggs, E Bernal-Mizrachi, M Ohsugi, J Wasson, S Fatrai, C Welling, ... Diabetologia 48, 2313-2321, 2005 | 269 | 2005 |
| Endoplasmic reticulum stress–induced apoptosis is partly mediated by reduced insulin signaling through phosphatidylinositol 3-kinase/Akt and increased glycogen synthase kinase … S Srinivasan, M Ohsugi, Z Liu, S Fatrai, E Bernal-Mizrachi, MA Permutt Diabetes 54 (4), 968-975, 2005 | 212 | 2005 |
| SUMOylation of Krüppel-like transcription factor 5 acts as a molecular switch in transcriptional programs of lipid metabolism involving PPAR-δ Y Oishi, I Manabe, K Tobe, M Ohsugi, T Kubota, K Fujiu, K Maemura, ... Nature medicine 14 (6), 656-666, 2008 | 190 | 2008 |
| The effectiveness of liraglutide in nonalcoholic fatty liver disease patients with type 2 diabetes mellitus compared to sitagliptin and pioglitazone T Ohki, A Isogawa, M Iwamoto, M Ohsugi, H Yoshida, N Toda, K Tagawa, ... The Scientific World Journal 2012, 2012 | 165 | 2012 |
| Glucose promotes pancreatic islet β-cell survival through a PI 3-kinase/Akt-signaling pathway S Srinivasan, E Bernal-Mizrachi, M Ohsugi, MA Permutt American Journal of Physiology-Endocrinology and Metabolism 283 (4), E784-E793, 2002 | 154 | 2002 |
| Body composition is the main determinant for the difference in type 2 diabetes pathophysiology between Japanese and Caucasians JB Møller, M Pedersen, H Tanaka, M Ohsugi, RV Overgaard, J Lynge, ... Diabetes care 37 (3), 796-804, 2014 | 146 | 2014 |
| Class IA phosphatidylinositol 3-kinase in pancreatic β cells controls insulin secretion by multiple mechanisms K Kaneko, K Ueki, N Takahashi, S Hashimoto, M Okamoto, M Awazawa, ... Cell metabolism 12 (6), 619-632, 2010 | 136 | 2010 |
| The RNA methyltransferase complex of WTAP, METTL3, and METTL14 regulates mitotic clonal expansion in adipogenesis M Kobayashi, M Ohsugi, T Sasako, M Awazawa, T Umehara, A Iwane, ... Molecular and cellular biology 38 (16), e00116-18, 2018 | 132 | 2018 |
| Reduced expression of the insulin receptor in mouse insulinoma (MIN6) cells reveals multiple roles of insulin signaling in gene expression, proliferation, insulin content, and … M Ohsugi, C Cras-Méneur, Y Zhou, E Bernal-Mizrachi, JD Johnson, ... Journal of Biological Chemistry 280 (6), 4992-5003, 2005 | 123 | 2005 |
| Ethnic differences in insulin sensitivity, β-cell function, and hepatic extraction between Japanese and Caucasians: a minimal model analysis JB Møller, C Dalla Man, RV Overgaard, SH Ingwersen, CW Tornøe, ... The Journal of Clinical Endocrinology & Metabolism 99 (11), 4273-4280, 2014 | 97 | 2014 |
| Effects of bowel preparation on the human gut microbiome and metabolome N Nagata, M Tohya, S Fukuda, W Suda, S Nishijima, F Takeuchi, ... Scientific reports 9 (1), 4042, 2019 | 94 | 2019 |
| Expression of DGAT2 in white adipose tissue is regulated by central leptin action R Suzuki, K Tobe, M Aoyama, K Sakamoto, M Ohsugi, N Kamei, ... Journal of Biological Chemistry 280 (5), 3331-3337, 2005 | 77 | 2005 |
