A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans GL Bond, W Hu, EE Bond, H Robins, SG Lutzker, NC Arva, J Bargonetti, ... Cell 119 (5), 591-602, 2004 | 1473 | 2004 |
Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function W Hu, C Zhang, R Wu, Y Sun, A Levine, Z Feng Proceedings of the National Academy of Sciences 107 (16), 7455-7460, 2010 | 887 | 2010 |
The P53 pathway: what questions remain to be explored? AJ Levine, W Hu, Z Feng Cell Death & Differentiation 13 (6), 1027-1036, 2006 | 876 | 2006 |
The regulation of AMPK β1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways Z Feng, W Hu, E De Stanchina, AK Teresky, S Jin, S Lowe, AJ Levine Cancer research 67 (7), 3043-3053, 2007 | 767 | 2007 |
p53 regulates maternal reproduction through LIF W Hu, Z Feng, AK Teresky, AJ Levine Nature 450 (7170), 721-724, 2007 | 542 | 2007 |
Acrolein is a major cigarette-related lung cancer agent: Preferential binding at p53 mutational hotspots and inhibition of DNA repair Z Feng, W Hu, Y Hu, M Tang Proceedings of the National Academy of Sciences 103 (42), 15404-15409, 2006 | 447 | 2006 |
Tumour-associated mutant p53 drives the Warburg effect C Zhang, J Liu, Y Liang, R Wu, Y Zhao, X Hong, M Lin, H Yu, L Liu, ... Nature communications 4 (1), 2935, 2013 | 444 | 2013 |
Parkin, a p53 target gene, mediates the role of p53 in glucose metabolism and the Warburg effect C Zhang, M Lin, R Wu, X Wang, B Yang, AJ Levine, W Hu, Z Feng Proceedings of the National Academy of Sciences 108 (39), 16259-16264, 2011 | 426 | 2011 |
A plausible model for the digital response of p53 to DNA damage L Ma, J Wagner, JJ Rice, W Hu, AJ Levine, GA Stolovitzky Proceedings of the National Academy of Sciences 102 (40), 14266-14271, 2005 | 415 | 2005 |
MDM2 is a central node in the p53 pathway: 12 years and counting GL Bond, W Hu, AJ Levine Current cancer drug targets 5 (1), 3-8, 2005 | 396 | 2005 |
Negative regulation of tumor suppressor p53 by microRNA miR-504 W Hu, CS Chan, R Wu, C Zhang, Y Sun, JS Song, LH Tang, AJ Levine, ... Molecular cell 38 (5), 689-699, 2010 | 360 | 2010 |
The origins and evolution of the p53 family of genes VA Belyi, P Ak, E Markert, H Wang, W Hu, A Puzio-Kuter, AJ Levine Cold Spring Harbor perspectives in biology 2 (6), a001198, 2010 | 348 | 2010 |
The major lipid peroxidation product, trans-4-hydroxy-2-nonenal, preferentially forms DNA adducts at codon 249 of human p53 gene, a unique mutational hotspot in hepatocellular … W Hu, Z Feng, J Eveleigh, G Iyer, J Pan, S Amin, FL Chung, M Tang Carcinogenesis 23 (11), 1781-1789, 2002 | 332 | 2002 |
Mutant p53 in cancer: accumulation, gain-of-function, and therapy X Yue, Y Zhao, Y Xu, M Zheng, Z Feng, W Hu Journal of molecular biology 429 (11), 1595-1606, 2017 | 318 | 2017 |
Tumor suppressor p53 meets microRNAs Z Feng, C Zhang, R Wu, W Hu Journal of molecular cell biology 3 (1), 44-50, 2011 | 299 | 2011 |
Declining p53 function in the aging process: a possible mechanism for the increased tumor incidence in older populations Z Feng, W Hu, AK Teresky, E Hernando, C Cordon-Cardo, AJ Levine Proceedings of the National Academy of Sciences 104 (42), 16633-16638, 2007 | 294 | 2007 |
Tumor suppressor p53 and its mutants in cancer metabolism J Liu, C Zhang, W Hu, Z Feng Cancer letters 356 (2), 197-203, 2015 | 277 | 2015 |
Tumor suppressor p53 and metabolism J Liu, C Zhang, W Hu, Z Feng Journal of molecular cell biology 11 (4), 284-292, 2019 | 247 | 2019 |
A single nucleotide polymorphism in the MDM2 gene: from a molecular and cellular explanation to clinical effect GL Bond, W Hu, A Levine Cancer research 65 (13), 5481-5484, 2005 | 239 | 2005 |
Single-nucleotide polymorphisms in the p53 pathway regulate fertility in humans HJ Kang, Z Feng, Y Sun, G Atwal, ME Murphy, TR Rebbeck, Z Rosenwaks, ... Proceedings of the National Academy of Sciences 106 (24), 9761-9766, 2009 | 230 | 2009 |