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Giovanni Grazioso
Giovanni Grazioso
Verified email at unimi.it
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Year
Lupin peptides modulate the protein-protein interaction of PCSK9 with the low density lipoprotein receptor in HepG2 cells
C Lammi, C Zanoni, G Aiello, A Arnoldi, G Grazioso
Scientific reports 6 (1), 29931, 2016
812016
Investigating the Mechanism of Substrate Uptake and Release in the Glutamate Transporter Homologue GltPh through Metadynamics Simulations
G Grazioso, V Limongelli, D Branduardi, E Novellino, C De Micheli, ...
Journal of the American Chemical Society 134 (1), 453-463, 2012
742012
Nicotine-modulated subunit stoichiometry affects stability and trafficking of α3β4 nicotinic receptor
F Mazzo, F Pistillo, G Grazioso, F Clementi, N Borgese, C Gotti, ...
Journal of Neuroscience 33 (30), 12316-12328, 2013
592013
Synthesis, binding affinity at glutamic acid receptors, neuroprotective effects, and molecular modeling investigation of novel dihydroisoxazole amino acids
P Conti, M De Amici, G Grazioso, G Roda, A Pinto, KB Hansen, B Nielsen, ...
Journal of medicinal chemistry 48 (20), 6315-6325, 2005
572005
Synthesis, chiral resolution, and enantiopharmacology of a potent 2, 3-benzodiazepine derivative as noncompetitive AMPA receptor antagonist
M Zappala, G Postorino, N Micale, S Caccamese, N Parrinello, ...
Journal of medicinal chemistry 49 (2), 575-581, 2006
482006
Disrupting the PCSK9/LDLR protein–protein interaction by an imidazole-based minimalist peptidomimetic
M Stucchi, G Grazioso, C Lammi, S Manara, C Zanoni, A Arnoldi, ...
Organic & Biomolecular Chemistry 14 (41), 9736-9740, 2016
432016
Alpha7 nicotinic acetylcholine receptor agonists: prediction of their binding affinity through a Molecular Mechanics Poisson–Boltzmann Surface Area approach
G Grazioso, A Cavalli, M De Amici, M Recanatini, C De Micheli
Journal of computational chemistry 29 (15), 2593-2602, 2008
432008
Engineering of α‐conotoxin MII‐derived peptides with increased selectivity for native α6β2 nicotinic acetylcholine receptors
L Pucci, G Grazioso, C Dallanoce, L Rizzi, C De Micheli, F Clementi, ...
The FASEB Journal 25 (11), 3775-3789, 2011
422011
Rational design of allosteric modulators of the aromatase enzyme: An unprecedented therapeutic strategy to fight breast cancer
A Spinello, S Martini, F Berti, M Pennati, M Pavlin, J Sgrignani, G Grazioso, ...
European journal of medicinal chemistry 168, 253-262, 2019
392019
Design, Synthesis, and Pharmacological Characterization of Novel Spirocyclic Quinuclidinyl‐Δ2‐Isoxazoline Derivatives as Potent and Selective Agonists of α7 …
C Dallanoce, P Magrone, C Matera, F Frigerio, G Grazioso, M De Amici, ...
ChemMedChem 6 (5), 889-903, 2011
392011
Inactivation of TEM-1 by avibactam (NXL-104): insights from quantum mechanics/molecular mechanics metadynamics simulations
J Sgrignani, G Grazioso, M De Amici, G Colombo
Biochemistry 53 (31), 5174-5185, 2014
382014
Peptidomimetics containing a vinyl ketone warhead as falcipain-2 inhibitors
R Ettari, M Zappalà, N Micale, G Grazioso, S Giofrè, T Schirmeister, ...
European journal of medicinal chemistry 46 (6), 2058-2065, 2011
382011
Determination of acid dissociation constants of compounds active at neuronal nicotinic acetylcholine receptors by means of electrophoretic and potentiometric techniques
G Roda, C Dallanoce, G Grazioso, V Liberti, M De Amici
Analytical Sciences 26 (1), 51-54, 2010
382010
The response of Escherichia coli biofilm to salicylic acid
C Cattò, G Grazioso, S Dell’Orto, A Gelain, S Villa, V Marzano, A Vitali, ...
Biofouling 33 (3), 235-251, 2017
342017
Mechanism of falcipain-2 inhibition by α, β-unsaturated benzo [1, 4] diazepin-2-one methyl ester
G Grazioso, L Legnani, L Toma, R Ettari, N Micale, C De Micheli
Journal of computer-aided molecular design 26, 1035-1043, 2012
322012
Synthesis and molecular modeling studies of derivatives of a highly potent peptidomimetic vinyl ester as falcipain‐2 inhibitors
R Ettari, N Micale, G Grazioso, F Bova, T Schirmeister, S Grasso, ...
ChemMedChem 7 (9), 1594-1600, 2012
322012
Design of novel α7-subtype-preferring nicotinic acetylcholine receptor agonists: Application of docking and MM-PBSA computational approaches, synthetic and pharmacological studies
G Grazioso, DY Pomè, C Matera, F Frigerio, L Pucci, C Gotti, C Dallanoce, ...
Bioorganic & medicinal chemistry letters 19 (22), 6353-6357, 2009
322009
Computationally driven structure optimization, synthesis, and biological evaluation of imidazole-based proprotein convertase subtilisin/kexin 9 (PCSK9) inhibitors
C Lammi, J Sgrignani, A Arnoldi, G Lesma, C Spatti, A Silvani, G Grazioso
Journal of medicinal chemistry 62 (13), 6163-6174, 2019
312019
Synthesis of enantiomerically pure HIP-A and HIP-B and investigation of their activity as inhibitors of excitatory amino acid transporters
A Pinto, P Conti, M De Amici, L Tamborini, G Grazioso, S Colleoni, ...
Tetrahedron: Asymmetry 19 (7), 867-875, 2008
312008
Design, synthesis, and pharmacological characterization of novel, potent NMDA receptor antagonists
P Conti, M De Amici, G Grazioso, G Roda, FF Barberis Negra, B Nielsen, ...
Journal of medicinal chemistry 47 (27), 6740-6748, 2004
302004
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