| Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine S Ito, L Shen, Q Dai, SC Wu, LB Collins, JA Swenberg, C He, Y Zhang Science 333 (6047), 1300-1303, 2011 | 2808 | 2011 |
| Distinct epigenomic landscapes of pluripotent and lineage-committed human cells RD Hawkins, GC Hon, LK Lee, QM Ngo, R Lister, M Pelizzola, LE Edsall, ... Cell stem cell 6 (5), 479-491, 2010 | 756 | 2010 |
| Genome-wide analysis reveals TET-and TDG-dependent 5-methylcytosine oxidation dynamics L Shen, H Wu, D Diep, S Yamaguchi, AC D’Alessio, HL Fung, K Zhang, ... Cell 153 (3), 692-706, 2013 | 465 | 2013 |
| AID/APOBEC deaminases disfavor modified cytosines implicated in DNA demethylation CS Nabel, H Jia, Y Ye, L Shen, HL Goldschmidt, JT Stivers, Y Zhang, ... Nature chemical biology 8 (9), 751-758, 2012 | 296 | 2012 |
| Embryonic development following somatic cell nuclear transfer impeded by persisting histone methylation S Matoba, Y Liu, F Lu, KA Iwabuchi, L Shen, A Inoue, Y Zhang Cell 159 (4), 884-895, 2014 | 268 | 2014 |
| Generation and replication-dependent dilution of 5fC and 5caC during mouse preimplantation development A Inoue, L Shen, Q Dai, C He, Y Zhang Cell research 21 (12), 1670-1676, 2011 | 265 | 2011 |
| Tet1 controls meiosis by regulating meiotic gene expression S Yamaguchi, K Hong, R Liu, L Shen, A Inoue, D Diep, K Zhang, Y Zhang Nature 492 (7429), 443-447, 2012 | 249 | 2012 |
| Kdm2b maintains murine embryonic stem cell status by recruiting PRC1 complex to CpG islands of developmental genes J He, L Shen, M Wan, O Taranova, H Wu, Y Zhang Nature cell biology 15 (4), 373-384, 2013 | 243 | 2013 |
| Mechanism and function of oxidative reversal of DNA and RNA methylation L Shen, CX Song, C He, Y Zhang Annual review of biochemistry 83, 585-614, 2014 | 242 | 2014 |
| Tet3 and DNA replication mediate demethylation of both the maternal and paternal genomes in mouse zygotes L Shen, A Inoue, J He, Y Liu, F Lu, Y Zhang Cell stem cell 15 (4), 459-471, 2014 | 186 | 2014 |
| Role of Tet1 in erasure of genomic imprinting S Yamaguchi, L Shen, Y Liu, D Sendler, Y Zhang Nature 504 (7480), 460-464, 2013 | 183 | 2013 |
| Rapamycin and other longevity‐promoting compounds enhance the generation of mouse induced pluripotent stem cells T Chen, L Shen, J Yu, H Wan, A Guo, J Chen, Y Long, J Zhao, G Pei Aging cell 10 (5), 908-911, 2011 | 183 | 2011 |
| Dynamics of 5-methylcytosine and 5-hydroxymethylcytosine during germ cell reprogramming S Yamaguchi, K Hong, R Liu, A Inoue, L Shen, K Zhang, Y Zhang Cell research 23 (3), 329-339, 2013 | 156 | 2013 |
| 5-Hydroxymethylcytosine: generation, fate, and genomic distribution L Shen, Y Zhang Current opinion in cell biology 25 (3), 289-296, 2013 | 133 | 2013 |
| Single-base resolution analysis of active DNA demethylation using methylase-assisted bisulfite sequencing H Wu, X Wu, L Shen, Y Zhang Nature biotechnology 32 (12), 1231-1240, 2014 | 112 | 2014 |
| Serum-based culture conditions provoke gene expression variability in mouse embryonic stem cells as revealed by single-cell analysis G Guo, L Pinello, X Han, S Lai, L Shen, TW Lin, K Zou, GC Yuan, ... Cell reports 14 (4), 956-965, 2016 | 65 | 2016 |
| Direct generation of human neuronal cells from adult astrocytes by small molecules L Gao, W Guan, M Wang, H Wang, J Yu, Q Liu, B Qiu, Y Yu, Y Ping, ... Stem cell reports 8 (3), 538-547, 2017 | 61 | 2017 |
| Inhibition of SNAP-25 phosphorylation at Ser187 is involved in chronic morphine-induced down-regulation of SNARE complex formation NJ Xu, YX Yu, JM Zhu, H Liu, L Shen, R Zeng, X Zhang, G Pei Journal of Biological Chemistry 279 (39), 40601-40608, 2004 | 50 | 2004 |
| CFP1 regulates histone H3K4 trimethylation and developmental potential in mouse oocytes C Yu, X Fan, QQ Sha, HH Wang, BT Li, XX Dai, L Shen, J Liu, L Wang, ... Cell reports 20 (5), 1161-1172, 2017 | 49 | 2017 |
| Loss of H3K27me3 imprinting in somatic cell nuclear transfer embryos disrupts post-implantation development S Matoba, H Wang, L Jiang, F Lu, KA Iwabuchi, X Wu, K Inoue, L Yang, ... Cell stem cell 23 (3), 343-354. e5, 2018 | 48 | 2018 |
