| Discovery of small-molecule inhibitors selectively targeting the DNA-binding domain of the human androgen receptor H Li, F Ban, K Dalal, E Leblanc, K Frewin, D Ma, H Adomat, PS Rennie, ... Journal of medicinal chemistry 57 (15), 6458-6467, 2014 | 145 | 2014 |
| Selectively targeting the DNA-binding domain of the androgen receptor as a prospective therapy for prostate cancer K Dalal, M Roshan-Moniri, A Sharma, H Li, F Ban, M Hessein, M Hsing, ... Journal of biological chemistry 289 (38), 26417-26429, 2014 | 143 | 2014 |
| Best practices of computer-aided drug discovery: lessons learned from the development of a preclinical candidate for prostate cancer with a new mechanism of action F Ban, K Dalal, H Li, E LeBlanc, PS Rennie, A Cherkasov Journal of chemical information and modeling 57 (5), 1018-1028, 2017 | 119 | 2017 |
| Targeting the binding function 3 (BF3) site of the androgen receptor through virtual screening. 2. Development of 2-((2-phenoxyethyl) thio)-1 H-benzimidazole derivatives RSN Munuganti, E Leblanc, P Axerio-Cilies, C Labriere, K Frewin, ... Journal of medicinal chemistry 56 (3), 1136-1148, 2013 | 96 | 2013 |
| Luteolin is a novel p90 ribosomal S6 kinase (RSK) inhibitor that suppresses Notch4 signaling by blocking the activation of Y-box binding protein-1 (YB-1) KM Reipas, JH Law, N Couto, S Islam, Y Li, H Li, A Cherkasov, K Jung, ... Oncotarget 4 (2), 329-45, 2013 | 64 | 2013 |
| Discovery of 1 H-Indole-2-carboxamides as Novel Inhibitors of the Androgen Receptor Binding Function 3 (BF3) F Ban, E Leblanc, H Li, RSN Munuganti, K Frewin, PS Rennie, ... Journal of medicinal chemistry 57 (15), 6867-6872, 2014 | 63 | 2014 |
| 3D-QSAR studies of HDACs inhibitors using pharmacophore-based alignment Y Chen, H Li, W Tang, C Zhu, Y Jiang, J Zou, Q Yu, Q You European journal of medicinal chemistry 44 (7), 2868-2876, 2009 | 55 | 2009 |
| A non-synonymous coding variant (L616F) in the TLR5 gene is potentially associated with Crohn's disease and influences responses to bacterial flagellin J Sheridan, DR Mack, DK Amre, DM Israel, A Cherkasov, H Li, G Grimard, ... PloS one 8 (4), e61326, 2013 | 40 | 2013 |
| Identification of novel androgen receptor antagonists using structure-and ligand-based methods H Li, X Ren, E Leblanc, K Frewin, PS Rennie, A Cherkasov Journal of chemical information and modeling 53 (1), 123-130, 2013 | 36 | 2013 |
| Virtual screening for Raf-1 kinase inhibitors based on pharmacophore model of substituted ureas HF Li, T Lu, T Zhu, YJ Jiang, SS Rao, LY Hu, BT Xin, YD Chen European journal of medicinal chemistry 44 (3), 1240-1249, 2009 | 36 | 2009 |
| Recent advances in the research and development of B-Raf inhibitors HF Li, Y Chen, SS Rao, XM Chen, HC Liu, JH Qin, WF Tang, X Zhou, T Lu Current medicinal chemistry 17 (16), 1618-1634, 2010 | 33 | 2010 |
| Characterization of a new class of androgen receptor antagonists with potential therapeutic application in advanced prostate cancer H Li, MDH Hassona, NA Lack, P Axerio-Cilies, E Leblanc, P Tavassoli, ... Molecular cancer therapeutics 12 (11), 2425-2435, 2013 | 32 | 2013 |
| Molecular modeling of exquisitely selective c-Met inhibitors through 3D-QSAR and molecular dynamics simulations H Yuan, J Zhuang, S Hu, H Li, J Xu, Y Hu, X Xiong, Y Chen, T Lu Journal of chemical information and modeling 54 (9), 2544-2554, 2014 | 25 | 2014 |
| Structure-based and shape-complemented pharmacophore modeling for the discovery of novel checkpoint kinase 1 inhibitors XM Chen, T Lu, S Lu, HF Li, HL Yuan, T Ran, HC Liu, YD Chen Journal of molecular modeling 16 (7), 1195-1204, 2010 | 25 | 2010 |
| Insight into the key interactions of bromodomain inhibitors based on molecular docking, interaction fingerprinting, molecular dynamics and binding free energy calculation T Ran, Z Zhang, K Liu, Y Lu, H Li, J Xu, X Xiong, Y Zhang, A Xu, S Lu, ... Molecular BioSystems 11 (5), 1295-1304, 2015 | 24 | 2015 |
| Investigation on the isoform selectivity of histone deacetylase inhibitors using chemical feature based pharmacophore and docking approaches Y Zhu, HF Li, S Lu, YX Zheng, Z Wu, WF Tang, X Zhou, T Lu European journal of medicinal chemistry 45 (5), 1777-1791, 2010 | 24 | 2010 |
| Pharmacophore identification of Raf-1 kinase inhibitors T Zhu, Y Jiao, YD Chen, X Wang, HF Li, LY Zhang, T Lu Bioorganic & medicinal chemistry letters 18 (7), 2346-2350, 2008 | 10 | 2008 |
