| Regulation of G2/M transition by inhibition of WEE1 and PKMYT1 kinases M Schmidt, A Rohe, C Platzer, A Najjar, F Erdmann, W Sippl Molecules 22 (12), 2045, 2017 | 166 | 2017 |
| Computer-aided design, synthesis and biological characterization of novel inhibitors for PKMYT1 A Najjar, C Platzer, A Luft, CA Aßmann, NH Elghazawy, F Erdmann, ... European Journal of Medicinal Chemistry 161, 479-492, 2019 | 18 | 2019 |
| Discovery of novel substituted benzo-anellated 4-benzylamino pyrrolopyrimidines as dual EGFR and VEGFR2 inhibitors T Fischer, T Krüger, A Najjar, F Totzke, C Schächtele, W Sippl, C Ritter, ... Bioorganic & Medicinal Chemistry Letters 27 (12), 2708-2712, 2017 | 17 | 2017 |
| Discovery of novel dual inhibitors of receptor tyrosine kinases EGFR and PDGFR-β related to anticancer drug resistance T Fischer, A Najjar, F Totzke, C Schächtele, W Sippl, C Ritter, A Hilgeroth J. Enzyme Inhib. Med. Chem. 33 (1), 1-8, 2018 | 16 | 2018 |
| Identification of Highly Potent Protein Kinase C‐Related Kinase 1 Inhibitors by Virtual Screening, Binding Free Energy Rescoring, and in vitro Testing I Slynko, K Schmidtkunz, T Rumpf, S Klaeger, S Heinzlmeir, A Najar, ... ChemMedChem 11 (18), 2084-2094, 2016 | 16 | 2016 |
| Cosmetics Europe evaluation of 6 in silico skin penetration models S Grégoire, I Sorrell, D Lange, A Najjar, A Schepky, C Ellison, J Troutman, ... Computational Toxicology 19, 100177, 2021 | 15 | 2021 |
| Identification of PKMYT1 inhibitors by screening the GSK published protein kinase inhibitor set I and II C Platzer, A Najjar, A Rohe, F Erdmann, W Sippl, M Schmidt Bioorganic & medicinal chemistry 26 (14), 4014-4024, 2018 | 14 | 2018 |
| Towards best use and regulatory acceptance of generic physiologically based kinetic (PBK) models for in vitro-to-in vivo extrapolation (IVIVE) in chemical risk assessment A Najjar, A Punt, J Wambaugh, A Paini, C Ellison, S Fragki, E Bianchi, ... Archives of Toxicology 96 (12), 3407-3419, 2022 | 11 | 2022 |
| Use of physiologically-based kinetics modelling to reliably predict internal concentrations of the UV filter, homosalate, after repeated oral and topical application A Najjar, A Schepky, CT Krueger, M Dent, S Cable, H Li, S Gregoire, ... Frontiers in Pharmacology 12, 3566, 2022 | 9 | 2022 |
| Physiologically based pharmacokinetic modeling software HJC C.E.Hack, A.Y.Efremenko, S.N.Pendse, Corie A.Ellison, A.Najjar, N.Hewitt ... Physiologically Based Pharmacokinetic (PBPK) Modeling, 81-126, 2020 | 9 | 2020 |
| Fragment-based drug design of nature-inspired compounds A Najjar, A Olğaç, F Ntie-Kang, W Sippl Physical Sciences Reviews 4 (9), 2019 | 6 | 2019 |
| The role of a molecular informatics platform to support next generation risk assessment C Yang, JF Rathman, B Bienfait, M Burbank, A Detroyer, SJ Enoch, ... Computational Toxicology 26, 100272, 2023 | 5 | 2023 |
| Development of a microphysiological skin-liver-thyroid Chip3 model and its application to evaluate the effects on thyroid hormones of topically applied cosmetic ingredients … TP Tao, I Maschmeyer, EL LeCluyse, E Rogers, K Brandmair, S Gerlach, ... Frontiers in Pharmacology 14, 1076254, 2023 | 5 | 2023 |
| Prediction of in vivo prenatal chlorpyrifos exposure leading to developmental neurotoxicity in humans based on in vitro toxicity data by quantitative in vitro-in vivo extrapolation EA Algharably, E Di Consiglio, E Testai, F Pistollato, A Bal-Price, A Najjar, ... Frontiers in Pharmacology 14, 563, 2023 | 5 | 2023 |
| Discovery of novel dual inhibitors of receptor tyrosine kinases EGFR and IGF-1R C Hempel, F Totzke, C Schächtele, A Najjar, W Sippl, C Ritter, A Hilgeroth Journal of enzyme inhibition and medicinal chemistry 32 (1), 271-276, 2017 | 5 | 2017 |
| Discovery of dually acting small-molecule inhibitors of cancer-resistance relevant receptor tyrosine kinases EGFR and IGF-1R C Hempel, A Najjar, F Totzke, C Schächtele, W Sippl, C Ritter, A Hilgeroth MedChemComm 7 (11), 2159-2166, 2016 | 5 | 2016 |
| A mechanistic Bayesian inferential workflow for estimation of In vivo skin permeation from In vitro measurements A Hamadeh, J Troutman, A Najjar, A Edginton Journal of Pharmaceutical Sciences 111 (3), 838-851, 2022 | 4 | 2022 |
| Computer-aid design of novel sulfonamide derivatives as EGFR kinase inhibitors for cancer treatment S Akili, DB Hadda, Y Bitar, A Najjar, MF Chehna International Journal of Organic Chemistry 11 (4), 171-186, 2021 | 4 | 2021 |
| Advances in and applications of predictive toxicology: 2022 A Najjar, N Kramer, I Gardner, T Hartung, T Steger-Hartmann Frontiers in Pharmacology 14, 1257423, 2023 | 2 | 2023 |
| Practical application of the interim internal threshold of toxicological concern (iTTC): a case study based on clinical data A Najjar, CA Ellison, S Gregoire, NJ Hewitt Archives of Toxicology 97 (1), 155-164, 2023 | 2 | 2023 |
