| Inhibition of lapatinib-induced kinome reprogramming in ERBB2-positive breast cancer by targeting BET family bromodomains TJ Stuhlmiller, SM Miller, JS Zawistowski, K Nakamura, AS Beltran, ... Cell reports 11 (3), 390-404, 2015 | 334 | 2015 |
| Enhancer remodeling during adaptive bypass to MEK inhibition is attenuated by pharmacologic targeting of the P-TEFb complex JS Zawistowski, SM Bevill, DR Goulet, TJ Stuhlmiller, AS Beltran, ... Cancer discovery 7 (3), 302-321, 2017 | 149 | 2017 |
| Unbiased analysis of RB-mediated transcriptional repression identifies novel targets and distinctions from E2F action MP Markey, SP Angus, MW Strobeck, SL Williams, RW Gunawardena, ... Cancer research 62 (22), 6587-6597, 2002 | 145 | 2002 |
| Compensation of BRG-1 Function by Brm: INSIGHT INTO THE ROLE OF THE CORE SWI· SNF SUBUNITS IN RETINOBLASTOMA TUMOR SUPPRESSOR SIGNALING MW Strobeck, DN Reisman, RW Gunawardena, BL Betz, SP Angus, ... Journal of Biological Chemistry 277 (7), 4782-4789, 2002 | 137 | 2002 |
| Molecular pathways: adaptive kinome reprogramming in response to targeted inhibition of the BRAF–MEK–ERK pathway in cancer GL Johnson, TJ Stuhlmiller, SP Angus, JS Zawistowski, LM Graves Clinical Cancer Research 20 (10), 2516-2522, 2014 | 136 | 2014 |
| MAP3K1: genomic alterations in cancer and function in promoting cell survival or apoptosis TT Pham, SP Angus, GL Johnson Genes & cancer 4 (11-12), 419-426, 2013 | 127 | 2013 |
| Retinoblastoma tumor suppressor targets dNTP metabolism to regulate DNA replication SP Angus, LJ Wheeler, SA Ranmal, X Zhang, MP Markey, CK Mathews, ... Journal of Biological Chemistry 277 (46), 44376-44384, 2002 | 123 | 2002 |
| Retinoblastoma tumor suppressor protein signals through inhibition of cyclin-dependent kinase 2 activity to disrupt PCNA function in S phase Z Sever-Chroneos, SP Angus, AF Fribourg, H Wan, I Todorov, ... Molecular and cellular biology 21 (12), 4032-4045, 2001 | 80 | 2001 |
| Redefining the MED13L syndrome A Adegbola, L Musante, B Callewaert, P Maciel, H Hu, B Isidor, ... European Journal of Human Genetics 23 (10), 1308-1317, 2015 | 79 | 2015 |
| New mechanisms of resistance to MEK inhibitors in melanoma revealed by intravital imaging HE Brighton, SP Angus, T Bo, J Roques, AC Tagliatela, DB Darr, ... Cancer research 78 (2), 542-557, 2018 | 71 | 2018 |
| Hierarchical requirement of SWI/SNF in retinoblastoma tumor suppressor-mediated repression of Plk1 RW Gunawardena, H Siddiqui, DA Solomon, CN Mayhew, J Held, ... Journal of Biological Chemistry 279 (28), 29278-29285, 2004 | 67 | 2004 |
| RB reversibly inhibits DNA replication via two temporally distinct mechanisms SP Angus, CN Mayhew, DA Solomon, WA Braden, MP Markey, Y Okuno, ... Molecular and cellular biology 24 (12), 5404-5420, 2004 | 67 | 2004 |
| Cabozantinib for neurofibromatosis type 1–related plexiform neurofibromas: a phase 2 trial MJ Fisher, CS Shih, SD Rhodes, AE Armstrong, PL Wolters, E Dombi, ... Nature medicine 27 (1), 165-173, 2021 | 57 | 2021 |
| Combination therapy with potent PI3K and MAPK inhibitors overcomes adaptive kinome resistance to single agents in preclinical models of glioblastoma RS McNeill, DA Canoutas, TJ Stuhlmiller, HD Dhruv, DM Irvin, RE Bash, ... Neuro-oncology 19 (11), 1469-1480, 2017 | 57 | 2017 |
| FOXO transcription factors control E2F1 transcriptional specificity and apoptotic function I Shats, ML Gatza, B Liu, SP Angus, L You, JR Nevins Cancer research 73 (19), 6056-6067, 2013 | 50 | 2013 |
| Active RB elicits late G1/S inhibition SP Angus, AF Fribourg, MP Markey, SL Williams, HF Horn, J DeGregori, ... Experimental cell research 276 (2), 201-213, 2002 | 48 | 2002 |
| GSK2801, a BAZ2/BRD9 bromodomain inhibitor, synergizes with BET inhibitors to induce apoptosis in triple-negative breast cancer SM Bevill, JF Olivares-Quintero, N Sciaky, BT Golitz, D Singh, AS Beltran, ... Molecular Cancer Research 17 (7), 1503-1518, 2019 | 46 | 2019 |
| Retinoblastoma tumor suppressor: analyses of dynamic behavior in living cells reveal multiple modes of regulation SP Angus, DA Solomon, L Kuschel, RF Hennigan, ES Knudsen Molecular and cellular biology 23 (22), 8172-8188, 2003 | 42 | 2003 |
| Interaction of E2F7 transcription factor with E2F1 and C-terminal-binding protein (CtBP) provides a mechanism for E2F7-dependent transcription repression B Liu, I Shats, SP Angus, ML Gatza, JR Nevins Journal of Biological Chemistry 288 (34), 24581-24589, 2013 | 36 | 2013 |
| Kinome and transcriptome profiling reveal broad and distinct activities of erlotinib, sunitinib, and sorafenib in the mouse heart and suggest cardiotoxicity from combined … TJ Stuhlmiller, JS Zawistowski, X Chen, N Sciaky, SP Angus, ST Hicks, ... Journal of the American Heart Association 6 (10), e006635, 2017 | 35 | 2017 |
Gary l JohnsonUniversity of North Carolina School of MedicineVerified email at med.unc.edu
