| The pyruvate dehydrogenase complexes: structure-based function and regulation MS Patel, NS Nemeria, W Furey, F Jordan Journal of Biological Chemistry 289 (24), 16615-16623, 2014 | 2757 | 2014 |
| Reaction mechanisms of thiamin diphosphate enzymes: defining states of ionization and tautomerization of the cofactor at individual steps NS Nemeria, S Chakraborty, A Balakrishnan, F Jordan The FEBS journal 276 (9), 2432-3446, 2009 | 2296 | 2009 |
| Structure and function of the catalytic domain of the dihydrolipoyl acetyltransferase component in Escherichia coli pyruvate dehydrogenase complex J Wang, NS Nemeria, K Chandrasekhar, S Kumaran, P Arjunan, ... Journal of Biological Chemistry 289 (22), 15215-15230, 2014 | 2258 | 2014 |
| Structure of the Pyruvate Dehydrogenase Multienzyme Complex E1 Component from Escherichia coli at 1.85 Ć Resolution, P Arjunan, N Nemeria, A Brunskill, K Chandrasekhar, M Sax, Yan, ... Biochemistry 41 (16), 5213-5221, 2002 | 172 | 2002 |
| Inhibition of the Escherichia coli pyruvate dehydrogenase complex E1 subunit and its tyrosine 177 variants by thiamin 2-thiazolone and thiamin 2-thiothiazolone diphosphates … N Nemeria, Y Yan, Z Zhang, AM Brown, P Arjunan, W Furey, JR Guest, ... Journal of Biological Chemistry 276 (49), 45969-45978, 2001 | 127 | 2001 |
| Tetrahedral intermediates in thiamin diphosphate-dependent decarboxylations exist as a 1 ‘, 4 ‘-imino tautomeric form of the coenzyme, unlike the Michaelis complex or the free … N Nemeria, A Baykal, E Joseph, S Zhang, Yan, W Furey, F Jordan Biochemistry 43 (21), 6565-6575, 2004 | 116 | 2004 |
| A thiamin-bound, pre-decarboxylation reaction intermediate analogue in the pyruvate dehydrogenase E1 subunit induces large scale disorder-to-order transformations in the enzyme … P Arjunan, M Sax, A Brunskill, K Chandrasekhar, N Nemeria, S Zhang, ... Journal of Biological Chemistry 281 (22), 15296-15303, 2006 | 109 | 2006 |
| The 1′, 4′-iminopyrimidine tautomer of thiamin diphosphate is poised for catalysis in asymmetric active centers on enzymes N Nemeria, S Chakraborty, A Baykal, LG Korotchkina, MS Patel, F Jordan Proceedings of the National Academy of Sciences 104 (1), 78-82, 2007 | 100 | 2007 |
| Dual catalytic apparatus of the thiamin diphosphate coenzyme: Acid− base via the 1 ‘, 4 ‘-iminopyrimidine tautomer along with its electrophilic role F Jordan, NS Nemeria, S Zhang, Yan, P Arjunan, W Furey Journal of the American Chemical Society 125 (42), 12732-12738, 2003 | 92 | 2003 |
| Observation of Thiamin-Bound Intermediates and Microscopic Rate Constants for Their Interconversion on 1-Deoxy-d-xylulose 5-Phosphate Synthase: 600-Fold Rate … H Patel, NS Nemeria, LA Brammer, CL Freel Meyers, F Jordan Journal of the American Chemical Society 134 (44), 18374-18379, 2012 | 74 | 2012 |
| Formation of reactive oxygen species by human and bacterial pyruvate and 2-oxoglutarate dehydrogenase multienzyme complexes reconstituted from recombinant components A Ambrus, NS Nemeria, B Torocsik, L Tretter, M Nilsson, F Jordan, ... Free Radical Biology and Medicine 89, 642-650, 2015 | 71 | 2015 |
| Elucidation of the chemistry of enzyme-bound thiamin diphosphate prior to substrate binding: defining internal equilibria among tautomeric and ionization states N Nemeria, L Korotchkina, MJ McLeish, GL Kenyon, MS Patel, F Jordan Biochemistry 46 (37), 10739-10744, 2007 | 63 | 2007 |
| Experimental observation of thiamin diphosphate-bound intermediates on enzymes and mechanistic information derived from these observations F Jordan, NS Nemeria Bioorganic chemistry 33 (3), 190-215, 2005 | 62 | 2005 |
| Effect of substitutions in the thiamin diphosphate-magnesium fold on the activation of the pyruvate dehydrogenase complex from Escherichia coli by cofactors and substrate J Yi, N Nemeria, A McNally, F Jordan, RS Machado, JR Guest Journal of Biological Chemistry 271 (52), 33192-33200, 1996 | 60 | 1996 |
| Regulation of thiamin diphosphate-dependent 2-oxo acid decarboxylases by substrate and thiamin diphosphate. Mg (II)–evidence for tertiary and quaternary interactions F Jordan, N Nemeria, F Guo, I Baburina, Y Gao, A Kahyaoglu, H Li, ... Biochimica et Biophysica Acta (BBA)-Protein Structure and Molecular …, 1998 | 58 | 1998 |
| Insight to the interaction of the dihydrolipoamide acetyltransferase (E2) core with the peripheral components in the Escherichia coli pyruvate dehydrogenase complex via … K Chandrasekhar, J Wang, P Arjunan, M Sax, YH Park, NS Nemeria, ... Journal of Biological Chemistry 288 (21), 15402-15417, 2013 | 54 | 2013 |
| Human 2-oxoglutarate dehydrogenase complex E1 component forms a thiamin-derived radical by aerobic oxidation of the enamine intermediate NS Nemeria, A Ambrus, H Patel, G Gerfen, V Adam-Vizi, L Tretter, J Zhou, ... Journal of Biological Chemistry 289 (43), 29859-29873, 2014 | 52 | 2014 |
| Structural Determinants of Enzyme Binding Affinity: The E1 Component of Pyruvate Dehydrogenase from Escherichia coli in Complex with the Inhibitor Thiamin Thiazolone … P Arjunan, K Chandrasekhar, M Sax, A Brunskill, N Nemeria, F Jordan, ... Biochemistry 43 (9), 2405-2411, 2004 | 52 | 2004 |
| The mitochondrial 2-oxoadipate and 2-oxoglutarate dehydrogenase complexes share their E2 and E3 components for their function and both generate reactive oxygen species NS Nemeria, G Gerfen, PR Nareddy, L Yang, X Zhang, M Szostak, ... Free Radical Biology and Medicine 115, 136-145, 2018 | 51 | 2018 |
| Double duty for a conserved glutamate in pyruvate decarboxylase: evidence of the participation in stereoelectronically controlled decarboxylation and in protonation of the … D Meyer, P Neumann, C Parthier, R Friedemann, N Nemeria, F Jordan, ... Biochemistry 49 (37), 8197-8212, 2010 | 48 | 2010 |
