|Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming|
RA Seder, R Gazzinelli, A Sher, WE Paul
Proceedings of the National Academy of Sciences 90 (21), 10188-10192, 1993
|In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction …|
RT Gazzinelli, M Wysocka, S Hieny, T Scharton-Kersten, A Cheever, ...
The Journal of Immunology 157 (2), 798-805, 1996
|Regulation and function of T-cell-mediated immunity during Toxoplasma gondii infection|
EY Denkers, RT Gazzinelli
Clinical microbiology reviews 11 (4), 569-588, 1998
|Interleukin 12 is required for the T-lymphocyte-independent induction of interferon gamma by an intracellular parasite and induces resistance in T-cell-deficient hosts|
RT Gazzinelli, S Hieny, TA Wynn, S Wolf, A Sher
Proceedings of the National Academy of Sciences 90 (13), 6115-6119, 1993
|IL-10 inhibits parasite killing and nitrogen oxide production by IFN-gamma-activated macrophages.|
RT Gazzinelli, IP Oswald, SL James, A Sher
The Journal of Immunology 148 (6), 1792-1796, 1992
|Parasite-induced IL-12 stimulates early IFN-gamma synthesis and resistance during acute infection with Toxoplasma gondii.|
RT Gazzinelli, M Wysocka, S Hayashi, EY Denkers, S Hieny, P Caspar, ...
The Journal of Immunology 153 (6), 2533-2543, 1994
|Synergistic role of CD4+ and CD8+ T lymphocytes in IFN-gamma production and protective immunity induced by an attenuated Toxoplasma gondii vaccine.|
RT Gazzinelli, FT Hakim, S Hieny, GM Shearer, A Sher
The Journal of Immunology 146 (1), 286-292, 1991
|Activation of Toll-like receptor-2 by glycosylphosphatidylinositol anchors from a protozoan parasite|
MAS Campos, IC Almeida, O Takeuchi, S Akira, EP Valente, DO Procópio, ...
The Journal of Immunology 167 (1), 416-423, 2001
|Guidelines for the use of flow cytometry and cell sorting in immunological studies|
A Cossarizza, HD Chang, A Radbruch, M Akdis, I Andrä, F Annunziato, ...
European journal of immunology 47 (10), 1584-1797, 2017
|Malaria hemozoin is immunologically inert but radically enhances innate responses by presenting malaria DNA to Toll-like receptor 9|
P Parroche, FN Lauw, N Goutagny, E Latz, BG Monks, A Visintin, ...
Proceedings of the National Academy of Sciences 104 (6), 1919-1924, 2007
|Simultaneous depletion of CD4+ and CD8+ T lymphocytes is required to reactivate chronic infection with Toxoplasma gondii.|
R Gazzinelli, Y Xu, S Hieny, A Cheever, A Sher
The Journal of Immunology 149 (1), 175-180, 1992
|Role of T-cell derived cytokines in the downregulation of immune responses in parasitic and retroviral infection.|
A Sher, RT Gazzinelli, IP Oswald, M Clerici, M Kullberg, EJ Pearce, ...
Immunological reviews 127, 183-204, 1992
|The microbicidal activity of interferon‐γ‐treated macrophages against Trypanosoma cruzi involves an L‐arginine‐dependent, nitrogen oxide‐mediated mechanism …|
RT Gazzinelli, IP Oswald, S Hieny, SL James, A Sher
European journal of immunology 22 (10), 2501-2506, 1992
|IL-10 synergizes with IL-4 and transforming growth factor-beta to inhibit macrophage cytotoxic activity.|
IP Oswald, RT Gazzinelli, A Sher, SL James
The Journal of Immunology 148 (11), 3578-3582, 1992
|In the absence of endogenous IFN-gamma, mice develop unimpaired IL-12 responses to Toxoplasma gondii while failing to control acute infection.|
TM Scharton-Kersten, TA Wynn, EY Denkers, S Bala, E Grunvald, S Hieny, ...
The Journal of Immunology 157 (9), 4045-4054, 1996
|Immnunological Control of Trypanosoma cruzi infection and pathogenesis of Chagas’ disease|
Z Brener, RT Gazzinelli
International archives of allergy and immunology 114 (2), 103-110, 1997
|Leishmania promastigotes selectively inhibit interleukin 12 induction in bone marrow-derived macrophages from susceptible and resistant mice.|
L Carrera, RT Gazzinelli, R Badolato, S Hieny, W Muller, R Kuhn, ...
The Journal of experimental medicine 183 (2), 515-526, 1996
|Protozoan encounters with Toll-like receptor signalling pathways: implications for host parasitism|
RT Gazzinelli, EY Denkers
Nature Reviews Immunology 6 (12), 895-906, 2006
|Acute cerebral toxoplasmosis is induced by in vivo neutralization of TNF-alpha and correlates with the down-regulated expression of inducible nitric oxide synthase and other …|
RT Gazzinelli, I Eltoum, TA Wynn, A Sher
The Journal of Immunology 151 (7), 3672-3681, 1993
|Cutting edge: TLR9 and TLR2 signaling together account for MyD88-dependent control of parasitemia in Trypanosoma cruzi infection|
A Bafica, HC Santiago, R Goldszmid, C Ropert, RT Gazzinelli, A Sher
The Journal of Immunology 177 (6), 3515-3519, 2006