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Thomas H Keller
Thomas H Keller
Investment Partner, Trinity Innovation Bioventures Singapore
Verified email at trinity-fund.com - Homepage
Title
Cited by
Cited by
Year
Spiroindolones, a potent compound class for the treatment of malaria
M Rottmann, C McNamara, BKS Yeung, MCS Lee, B Zou, B Russell, ...
science 329 (5996), 1175-1180, 2010
11962010
PA-824 Kills Nonreplicating Mycobacterium tuberculosis by Intracellular NO Release
R Singh, U Manjunatha, HIM Boshoff, YH Ha, P Niyomrattanakit, ...
Science 322 (5906), 1392-1395, 2008
9212008
Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus
P Erbel, N Schiering, A D'Arcy, M Renatus, M Kroemer, SP Lim, Z Yin, ...
Nature structural & molecular biology 13 (4), 372-373, 2006
6342006
Spirotetrahydro β-carbolines (spiroindolones): a new class of potent and orally efficacious compounds for the treatment of malaria
BKS Yeung, B Zou, M Rottmann, SB Lakshminarayana, SH Ang, ...
Journal of medicinal chemistry 53 (14), 5155-5164, 2010
4562010
An adenosine nucleoside inhibitor of dengue virus
Z Yin, YL Chen, W Schul, QY Wang, F Gu, J Duraiswamy, RR Kondreddi, ...
Proceedings of the National Academy of Sciences 106 (48), 20435-20439, 2009
3932009
A practical view of ‘druggability’
TH Keller, A Pichota, Z Yin
Current opinion in chemical biology 10 (4), 357-361, 2006
3392006
Wnt addiction of genetically defined cancers reversed by PORCN inhibition
B Madan, Z Ke, N Harmston, SY Ho, AO Frois, J Alam, DA Jeyaraj, ...
Oncogene 35 (17), 2197-2207, 2016
3222016
A chemical genetic screen in Mycobacterium tuberculosis identifies carbon-source-dependent growth inhibitors devoid of in vivo efficacy
K Pethe, PC Sequeira, S Agarwalla, K Rhee, K Kuhen, WY Phong, V Patel, ...
Nature communications 1 (1), 57, 2010
3162010
A small-molecule dengue virus entry inhibitor
QY Wang, SJ Patel, E Vangrevelinghe, HY Xu, R Rao, D Jaber, W Schul, ...
Antimicrobial agents and chemotherapy 53 (5), 1823-1831, 2009
2392009
Peptide inhibitors of Dengue virus NS3 protease. Part 1: Warhead
Z Yin, SJ Patel, WL Wang, G Wang, WL Chan, KRR Rao, J Alam, ...
Bioorganic & medicinal chemistry letters 16 (1), 36-39, 2006
2122006
Small molecule inhibitors that selectively block dengue virus methyltransferase
SP Lim, LS Sonntag, C Noble, SH Nilar, RH Ng, G Zou, P Monaghan, ...
Journal of Biological Chemistry 286 (8), 6233-6240, 2011
1852011
Peptide inhibitors of dengue virus NS3 protease. Part 2: SAR study of tetrapeptide aldehyde inhibitors
Z Yin, SJ Patel, WL Wang, WL Chan, KRR Rao, G Wang, X Ngew, V Patel, ...
Bioorganic & medicinal chemistry letters 16 (1), 40-43, 2006
1812006
Structure− activity relationships of antitubercular nitroimidazoles. 1. Structural features associated with aerobic and anaerobic activities of 4-and 5-nitroimidazoles
P Kim, L Zhang, UH Manjunatha, R Singh, S Patel, J Jiricek, TH Keller, ...
Journal of medicinal chemistry 52 (5), 1317-1328, 2009
1242009
Inhibition of dengue virus polymerase by blocking of the RNA tunnel
P Niyomrattanakit, YL Chen, H Dong, Z Yin, M Qing, JF Glickman, K Lin, ...
Journal of virology 84 (11), 5678-5686, 2010
1232010
Imidazolopiperazines: hit to lead optimization of new antimalarial agents
T Wu, A Nagle, K Kuhen, K Gagaring, R Borboa, C Francek, Z Chen, ...
Journal of medicinal chemistry 54 (14), 5116-5130, 2011
1162011
A fluorescence quenching assay to discriminate between specific and nonspecific inhibitors of dengue virus protease
C Bodenreider, D Beer, TH Keller, S Sonntag, D Wen, LJ Yap, YH Yau, ...
Analytical biochemistry 395 (2), 195-204, 2009
1162009
Lipiarmycin targets RNA polymerase and has good activity against multidrug-resistant strains of Mycobacterium tuberculosis
M Kurabachew, SHJ Lu, P Krastel, EK Schmitt, BL Suresh, A Goh, ...
Journal of antimicrobial chemotherapy 62 (4), 713-719, 2008
1152008
Structural dynamics of Zika virus NS2B-NS3 protease binding to dipeptide inhibitors
Y Li, Z Zhang, WW Phoo, YR Loh, W Wang, S Liu, MW Chen, AW Hung, ...
Structure 25 (8), 1242-1250. e3, 2017
1102017
The Identification of Indacaterol as an Ultralong-Acting Inhaled β2-Adrenoceptor Agonist
F Baur, D Beattie, D Beer, D Bentley, M Bradley, I Bruce, SJ Charlton, ...
Journal of medicinal chemistry 53 (9), 3675-3684, 2010
1102010
Global Bayesian models for the prioritization of antitubercular agents
P Prathipati, NL Ma, TH Keller
Journal of chemical information and modeling 48 (12), 2362-2370, 2008
1102008
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