| Protein structure and sequence reanalysis of 2019-nCoV genome refutes snakes as its intermediate host and the unique similarity between its spike protein insertions and HIV-1 C Zhang, W Zheng, X Huang, EW Bell, X Zhou, Y Zhang Journal of Proteome Research 19 (4), 1351-1360, 2020 | 360 | 2020 |
| De novo Design of Protein Peptides to Block Association of the SARS-CoV-2 Spike Protein with Human ACE2 X Huang, R Pearce, Y Zhang Aging (Albany NY) 12 (12), 11263-11276, 2020 | 113* | 2020 |
| Effects of SARS‐CoV‐2 mutations on protein structures and intraviral protein–protein interactions S Wu, C Tian, P Liu, D Guo, W Zheng, X Huang, Y Zhang, L Liu Journal of medical virology 93 (4), 2132-2140, 2020 | 106 | 2020 |
| EvoEF2: accurate and fast energy function for computational protein design X Huang, R Pearce, Y Zhang Bioinformatics 36, 1135–1142, 2020 | 82 | 2020 |
| EvoDesign: Designing Protein–Protein Binding Interactions Using Evolutionary Interface Profiles in Conjunction with an Optimized Physical Energy Function R Pearce, X Huang, D Setiawan, Y Zhang Journal of molecular biology 431, 2467-2476, 2019 | 69 | 2019 |
| Protein structure prediction using deep learning distance and hydrogen‐bonding restraints in CASP14 W Zheng, Y Li, C Zhang, X Zhou, R Pearce, EW Bell, X Huang, Y Zhang Proteins: Structure, Function, and Bioinformatics, 2021 | 56 | 2021 |
| FASPR: an open-source tool for fast and accurate protein side-chain packing X Huang, R Pearce, Y Zhang Bioinformatics 36 (12), 3758-3765, 2020 | 53 | 2020 |
| SSIPe: accurately estimating protein–protein binding affinity change upon mutations using evolutionary profiles in combination with an optimized physical energy function X Huang, W Zheng, R Pearce, Y Zhang Bioinformatics 36 (8), 2429-2437, 2020 | 43 | 2020 |
| Systematic optimization model and algorithm for binding sequence selection in computational enzyme design X Huang, K Han, Y Zhu Protein Science 22 (7), 929-941, 2013 | 38 | 2013 |
| Identifying the Zoonotic Origin of SARS-CoV-2 by Modeling the Binding Affinity between the Spike Receptor-Binding Domain and Host ACE2 X Huang, C Zhang, R Pearce, GS Omenn, Y Zhang Journal of proteome research 19 (12), 4844-4856, 2020 | 37 | 2020 |
| Computational redesign of penicillin acylase for cephradine synthesis with high kinetic selectivity J He, X Huang, J Xue, Y Zhu Green Chemistry 20 (24), 5484-5490, 2018 | 32 | 2018 |
| Recent Advances in Improving Gene-Editing Specificity through CRISPR–Cas9 Nuclease Engineering X Huang, D Yang, J Zhang, J Xu, YE Chen Cells 11 (14), 2186, 2022 | 28 | 2022 |
| Computational design of variants for cephalosporin C acylase from Pseudomonas strain N176 with improved stability and activity Y Tian, X Huang, Q Li, Y Zhu Applied microbiology and biotechnology 101 (2), 621-632, 2017 | 24 | 2017 |
| Computational design of enzyme–ligand binding using a combined energy function and deterministic sequence optimization algorithm Y Tian, X Huang, Y Zhu Journal of molecular modeling 21 (8), 1-14, 2015 | 24 | 2015 |
| Computational design of SARS-CoV-2 spike glycoproteins to increase immunogenicity by T cell epitope engineering E Ong, X Huang, R Pearce, Y Zhang, Y He Computational and structural biotechnology journal, 2020 | 23 | 2020 |
| Use of an improved matching algorithm to select scaffolds for enzyme design based on a complex active site model X Huang, J Xue, M Lin, Y Zhu PloS one 11 (5), e0156559, 2016 | 23 | 2016 |
| Using molecular dynamics simulations to evaluate active designs of cephradine hydrolase by molecular mechanics/Poisson–Boltzmann surface area and molecular mechanics … J Xue, X Huang, Y Zhu RSC advances 9 (24), 13868-13877, 2019 | 21 | 2019 |
| Computational design of cephradine synthase in a new scaffold identified from structural databases X Huang, J Xue, Y Zhu Chemical Communications 53 (54), 7604-7607, 2017 | 21 | 2017 |
| Changing the apoptosis pathway through evolutionary protein design D Shultis, P Mitra, X Huang, J Johnson, NA Khattak, F Gray, C Piper, ... Journal of molecular biology 431 (4), 825-841, 2019 | 18 | 2019 |
| Evaluation of active designs of cephalosporin C acylase by molecular dynamics simulation and molecular docking Q Li, X Huang, Y Zhu Journal of molecular modeling 20 (7), 2314, 2014 | 18 | 2014 |
