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Jan Jiricek
Jan Jiricek
Senior Research Investigator at Novartis
Verified email at novartis.com
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Cited by
Cited by
Year
PA-824 Kills Nonreplicating Mycobacterium tuberculosis by Intracellular NO Release
R Singh, U Manjunatha, HIM Boshoff, YH Ha, P Niyomrattanakit, ...
Science 322 (5906), 1392-1395, 2008
9202008
Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis
K Pethe, P Bifani, J Jang, S Kang, S Park, S Ahn, J Jiricek, J Jung, ...
Nature medicine 19 (9), 1157-1160, 2013
6052013
A chemical genetic screen in Mycobacterium tuberculosis identifies carbon-source-dependent growth inhibitors devoid of in vivo efficacy
K Pethe, PC Sequeira, S Agarwalla, K Rhee, K Kuhen, WY Phong, V Patel, ...
Nature communications 1 (1), 57, 2010
3162010
Functional profiling of recombinant NS3 proteases from all four serotypes of dengue virus using tetrapeptide and octapeptide substrate libraries
J Li, SP Lim, D Beer, V Patel, D Wen, C Tumanut, DC Tully, JA Williams, ...
Journal of Biological Chemistry 280 (31), 28766-28774, 2005
2932005
Ruthenium olefin metathesis catalysts with modified styrene ethers: influence of steric and electronic effects
M Zaja, SJ Connon, AM Dunne, M Rivard, N Buschmann, J Jiricek, ...
Tetrahedron 59 (34), 6545-6558, 2003
2102003
Indolcarboxamide is a preclinical candidate for treating multidrug-resistant tuberculosis
SPS Rao, SB Lakshminarayana, RR Kondreddi, M Herve, LR Camacho, ...
Science translational medicine 5 (214), 214ra168-214ra168, 2013
1642013
Structure− activity relationships of antitubercular nitroimidazoles. 1. Structural features associated with aerobic and anaerobic activities of 4-and 5-nitroimidazoles
P Kim, L Zhang, UH Manjunatha, R Singh, S Patel, J Jiricek, TH Keller, ...
Journal of medicinal chemistry 52 (5), 1317-1328, 2009
1252009
Lipiarmycin targets RNA polymerase and has good activity against multidrug-resistant strains of Mycobacterium tuberculosis
M Kurabachew, SHJ Lu, P Krastel, EK Schmitt, BL Suresh, A Goh, ...
Journal of antimicrobial chemotherapy 62 (4), 713-719, 2008
1152008
Design, synthesis, and biological evaluation of indole-2-carboxamides: a promising class of antituberculosis agents
RR Kondreddi, J Jiricek, SPS Rao, SB Lakshminarayana, LR Camacho, ...
Journal of medicinal chemistry 56 (21), 8849-8859, 2013
1052013
Structure− activity relationships of antitubercular nitroimidazoles. 2. Determinants of aerobic activity and quantitative structure− activity relationships
P Kim, S Kang, HI Boshoff, J Jiricek, M Collins, R Singh, UH Manjunatha, ...
Journal of medicinal chemistry 52 (5), 1329-1344, 2009
1052009
Enantioselective synthesis of (−)-gilbertine via a cationic cascade cyclization
J Jiricek, S Blechert
Journal of the American Chemical Society 126 (11), 3534-3538, 2004
932004
Design, synthesis and biological evaluation of aryl-substituted sialyl Lewis X mimetics prepared via cross-metathesis of C-fucopeptides
CM Huwe, TJ Woltering, J Jiricek, G Weitz-Schmidt, CH Wong
Bioorganic & medicinal chemistry 7 (5), 773-788, 1999
801999
Discovery and characterization of clinical candidate LXE408 as a kinetoplastid-selective proteasome inhibitor for the treatment of leishmaniases
A Nagle, A Biggart, C Be, H Srinivas, A Hein, D Caridha, RJ Sciotti, ...
Journal of Medicinal Chemistry 63 (19), 10773-10781, 2020
672020
Discovery of tetrahydropyrazolopyrimidine carboxamide derivatives as potent and orally active antitubercular agents
F Yokokawa, G Wang, WL Chan, SH Ang, J Wong, I Ma, SPS Rao, ...
ACS Medicinal Chemistry Letters 4 (5), 451-455, 2013
542013
Targeting the trypanosome kinetochore with CLK1 protein kinase inhibitors
M Saldivia, E Fang, X Ma, E Myburgh, JBT Carnielli, C Bower-Lepts, ...
Nature microbiology 5 (10), 1207-1216, 2020
492020
Structure–Activity Relationships of Antitubercular Nitroimidazoles. 3. Exploration of the Linker and Lipophilic Tail of ((S)-2-Nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3 …
J Cherian, I Choi, A Nayyar, UH Manjunatha, T Mukherjee, YS Lee, ...
Journal of medicinal chemistry 54 (16), 5639-5659, 2011
442011
Lanthanide triple helical complexes with a chiral ligand derived from 2, 6-pyridinedicarboxylic acid
G Muller, B Schmidt, J Jiricek, G Hopfgartner, JP Riehl, JCG Bünzli, ...
Journal of the Chemical Society, Dalton Transactions, 2655-2662, 2001
422001
Pharmacokinetics-pharmacodynamics analysis of bicyclic 4-nitroimidazole analogs in a murine model of tuberculosis
SB Lakshminarayana, HIM Boshoff, J Cherian, S Ravindran, A Goh, ...
PloS one 9 (8), e105222, 2014
262014
Cyanotriazoles are selective topoisomerase II poisons that rapidly cure trypanosome infections
SPS Rao, MK Gould, J Noeske, M Saldivia, RS Jumani, PS Ng, O René, ...
Science 380 (6652), 1349-1356, 2023
122023
Anti-trypanosomal proteasome inhibitors cure hemolymphatic and meningoencephalic murine infection models of African trypanosomiasis
SPS Rao, SB Lakshminarayana, J Jiricek, M Kaiser, R Ritchie, E Myburgh, ...
Tropical medicine and infectious disease 5 (1), 28, 2020
122020
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