| Environmental changes bridge evolutionary valleys B Steinberg, M Ostermeier Science advances 2 (1), e1500921, 2016 | 120 | 2016 |
| Shifting fitness and epistatic landscapes reflect trade-offs along an evolutionary pathway B Steinberg, M Ostermeier Journal of molecular biology 428 (13), 2730-2743, 2016 | 53 | 2016 |
| Methods and compositions for modulating a genome JR Rubens, GA Von Maltzahn, RJ Citorik, BE Steinberg, D Li US Patent App. 16/706,448, 2020 | 33 | 2020 |
| Identification of guide-intrinsic determinants of Cas9 specificity NC Huston, J Tycko, EL Tillotson, CJ Wilson, VE Myer, H Jayaram, ... The CRISPR journal 2 (3), 172-185, 2019 | 22 | 2019 |
| SMOOT libraries and phage-induced directed evolution of Cas9 to engineer reduced off-target activity D Cerchione, K Loveluck, EL Tillotson, F Harbinski, J DaSilva, CP Kelley, ... PLoS One 15 (4), e0231716, 2020 | 16 | 2020 |
| Consequences of a telomerase-related fitness defect and chromosome substitution technology in yeast synIX strains LH McCulloch, V Sambasivam, AL Hughes, N Annaluru, S Ramalingam, ... Cell Genomics 3 (11), 2023 | 8 | 2023 |
| Systems and methods for one-shot guide RNA (ogRNA) targeting of endogenous and source DNA AE Friedland, H Jayaram, BE Steinberg US Patent 9,963,719, 2018 | 7 | 2018 |
| Engineered Cas9 nucleases BE Steinberg, D Cerchione US Patent 10,428,319, 2019 | 6 | 2019 |
| Systems and methods for one-shot guide RNA (ogRNA) targeting of endogenous and source DNA AE Friedland, H Jayaram, BE Steinberg US Patent 10,006,054, 2018 | 5 | 2018 |
| Engineered Cas9 nucleases BE Steinberg, D Cerchione US Patent 11,098,297, 2021 | 3 | 2021 |
| Systems and methods for one-shot guide RNA (ogRNA) targeting of endogenous and source DNA AE Friedland, H Jayaram, BE Steinberg US Patent 10,494,649, 2019 | 1 | 2019 |
| Cftr-modulating compositions and methods RC Altshuler, AH Bothmer, DR Chee, CGS Cotta-Ramusino, K Kim, ... US Patent App. 18/470,687, 2024 | | 2024 |
| Pah-modulating compositions and methods RC Altshuler, AH Bothmer, DR Chee, CGS Cotta-Ramusino, K Kim, ... US Patent App. 18/495,276, 2024 | | 2024 |
| Methods and compositions for modulating a genome SH Cleaver, BE Steinberg, JR Rubens, RJ Citorik, WE Salomon, ZJ Wang US Patent App. 18/467,428, 2024 | | 2024 |
| Nucleic acid mutagenesis methods BE Steinberg US Patent App. 18/110,444, 2024 | | 2024 |
| Serpina-modulating compositions and methods RC Altshuler, AH Bothmer, DR Chee, CGS Cotta-Ramusino, K Kim, ... US Patent App. 18/469,344, 2024 | | 2024 |
| Methods and compositions for modulating a genome SH Cleaver, BE Steinberg, JR Rubens, RJ Citorik, WE Salomon, ZJ Wang US Patent App. 18/467,392, 2024 | | 2024 |
| Methods and compositions for modulating a genome RC Altshuler, AH Bothmer, CGS Cotta-Ramusino, RM Kotlar, ... US Patent App. 18/447,681, 2024 | | 2024 |
| Methods and compositions for modulating a genome AH Bothmer, CGS Cotta-Ramusino, WE Salomon, JR Rubens, RJ Citorik, ... US Patent App. 18/355,017, 2024 | | 2024 |
| Methods and compositions for modulating a genome RC Altshuler, AH Bothmer, CGS Cotta-Ramusino, RM Kotlar, ... US Patent App. 18/447,515, 2024 | | 2024 |
Marc OstermeierProfessor of Chemical and Biomolecular Engineering, Johns Hopkins UniversityVerified email at jhu.edu
