Thomas Lundbäck
Thomas Lundbäck
Director, Mechanistic and Structural Biology, R&D, AstraZeneca
astrazeneca.com üzerinde doğrulanmış e-posta adresine sahip - Ana Sayfa
Başlık
Alıntı yapanlar
Alıntı yapanlar
Yıl
The cellular thermal shift assay for evaluating drug target interactions in cells
R Jafari, H Almqvist, H Axelsson, M Ignatushchenko, T Lundbäck, ...
Nature protocols 9 (9), 2100-2122, 2014
6102014
MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool
H Gad, T Koolmeister, AS Jemth, S Eshtad, SA Jacques, CE Ström, ...
Nature 508 (7495), 215-221, 2014
4162014
Solution structure and DNA-binding properties of a thermostable protein from the archaeon Sulfolobus solfataricus
H Baumann, S Knapp, T Lundbäck, R Ladenstein, T Härd
Nature structural biology 1 (11), 808-819, 1994
2061994
Oligomerization of the chromatin‐structuring protein H‐NS
CP Smyth, T Lundbäck, D Renzoni, G Siligardi, R Beavil, M Layton, ...
Molecular microbiology 36 (4), 962-972, 2000
1272000
CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil
H Almqvist, H Axelsson, R Jafari, C Dan, A Mateus, M Haraldsson, ...
Nature communications 7 (1), 1-11, 2016
1122016
Thermodynamic characterization of non-sequence-specific DNA-binding by the Sso7d protein from Sulfolobus solfataricus
T Lundbäck, H Hansson, S Knapp, R Ladenstein, T Härd
Journal of molecular biology 276 (4), 775-786, 1998
1011998
N-Benzyl-indolo carboxylic acids: Design and synthesis of potent and selective adipocyte fatty-acid binding protein (A-FABP) inhibitors
T Barf, F Lehmann, K Hammer, S Haile, E Axen, C Medina, J Uppenberg, ...
Bioorganic & medicinal chemistry letters 19 (6), 1745-1748, 2009
932009
Discovery of inhibitors of human adipocyte fatty acid-binding protein, a potential type 2 diabetes target
F Lehmann, S Haile, E Axen, C Medina, J Uppenberg, S Svensson, ...
Bioorganic & medicinal chemistry letters 14 (17), 4445-4448, 2004
852004
Sequence-specific DNA-binding dominated by dehydration
T Lundbäck, T Härd
Proceedings of the National Academy of Sciences 93 (10), 4754-4759, 1996
851996
Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies
N Herold, SG Rudd, L Ljungblad, K Sanjiv, IH Myrberg, CBJ Paulin, ...
Nature medicine 23 (2), 256-263, 2017
832017
Substituted benzylamino-6-(trifluoromethyl)pyrimidin-4(1H)-ones: a novel class of selective human A-FABP inhibitors
R Ringom, E Axen, J Uppenberg, T Lundbäck, L Rondahl, T Barf
Bioorganic & medicinal chemistry letters 14 (17), 4449-4452, 2004
742004
Structure-based screening as applied to human FABP4: a highly efficient alternative to HTS for hit generation
MJP van Dongen, J Uppenberg, S Svensson, T Lundbäck, T Åkerud, ...
Journal of the American Chemical Society 124 (40), 11874-11880, 2002
732002
Thermodynamics of sequence-specific protein-DNA interactions
T Härd, T Lundbäck
Biophysical chemistry 62 (1-3), 121-139, 1996
731996
Prediction of intracellular exposure bridges the gap between target-and cell-based drug discovery
A Mateus, LJ Gordon, GJ Wayne, H Almqvist, H Axelsson, ...
Proceedings of the National Academy of Sciences 114 (30), E6231-E6239, 2017
632017
Thermodynamics of the glucocorticoid receptor-DNA interaction: binding of wild-type GR DBD to different response elements
T Lundbäck, C Cairns, JÅ Gustafsson, J Carlstedt-Duke, T Härd
Biochemistry 32 (19), 5074-5082, 1993
631993
Oct-1 POU and octamer DNA co-operate to recognise the Bob-1 transcription co-activator via induced folding
JF Chang, K Phillips, T LundbaÈck, M Gstaiger, JE Ladbury, B Luisi
Journal of molecular biology 288 (5), 941-952, 1999
551999
Thermodynamics of sequence-specific glucocorticoid receptor-DNA interactions
T Lundbäck, J Zilliacus, JÅ Gustafsson, J Carlstedt-Duke, T Härd
Biochemistry 33 (19), 5955-5965, 1994
501994
Salt dependence of the free energy, enthalpy, and entropy of nonsequence specific DNA binding
T Lundbäck, T Härd
The Journal of Physical Chemistry 100 (44), 17690-17695, 1996
471996
Structure–activity relationships of synthetic cordycepin analogues as experimental therapeutics for African trypanosomiasis
SK Vodnala, T Lundbäck, E Yeheskieli, B Sjöberg, AL Gustavsson, ...
Journal of medicinal chemistry 56 (24), 9861-9873, 2013
432013
Binding to and inhibition of insulin-regulated aminopeptidase by macrocyclic disulfides enhances spine density
S Diwakarla, E Nylander, A Grönbladh, SR Vanga, YS Khan, ...
Molecular pharmacology 89 (4), 413-424, 2016
402016
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