Gut microbiome in health and disease: Linking the microbiome–gut–brain axis and environmental factors in the pathogenesis of systemic and neurodegenerative diseases S Ghaisas, J Maher, A Kanthasamy Pharmacology & therapeutics 158, 52-62, 2016 | 546 | 2016 |
Mitochondrial impairment in microglia amplifies NLRP3 inflammasome proinflammatory signaling in cell culture and animal models of Parkinson’s disease S Sarkar, E Malovic, DS Harishchandra, S Ghaisas, N Panicker, A Charli, ... npj Parkinson's Disease 3 (1), 30, 2017 | 228 | 2017 |
Manganese-induced neurotoxicity: new insights into the triad of protein misfolding, mitochondrial impairment, and neuroinflammation DS Harischandra, S Ghaisas, G Zenitsky, H Jin, A Kanthasamy, ... Frontiers in neuroscience 13, 465315, 2019 | 201 | 2019 |
Fyn kinase regulates misfolded α-synuclein uptake and NLRP3 inflammasome activation in microglia N Panicker, S Sarkar, DS Harischandra, M Neal, TI Kam, H Jin, ... Journal of Experimental Medicine 216 (6), 1411-1430, 2019 | 198 | 2019 |
Manganese promotes the aggregation and prion-like cell-to-cell exosomal transmission of α-synuclein DS Harischandra, D Rokad, ML Neal, S Ghaisas, S Manne, S Sarkar, ... Science signaling 12 (572), eaau4543, 2019 | 148 | 2019 |
Nanoneuromedicines for degenerative, inflammatory, and infectious nervous system diseases HE Gendelman, V Anantharam, T Bronich, S Ghaisas, H Jin, ... Nanomedicine: Nanotechnology, Biology and Medicine 11 (3), 751-767, 2015 | 123 | 2015 |
Mito-apocynin prevents mitochondrial dysfunction, microglial activation, oxidative damage, and progressive neurodegeneration in MitoPark transgenic mice M Langley, A Ghosh, A Charli, S Sarkar, M Ay, J Luo, J Zielonka, T Brenza, ... Antioxidants & redox signaling 27 (14), 1048-1066, 2017 | 116 | 2017 |
Neuronal protection against oxidative insult by polyanhydride nanoparticle-based mitochondria-targeted antioxidant therapy TM Brenza, S Ghaisas, JEV Ramirez, D Harischandra, V Anantharam, ... Nanomedicine: Nanotechnology, biology and medicine 13 (3), 809-820, 2017 | 91 | 2017 |
Environmental neurotoxicant manganese regulates exosome-mediated extracellular miRNAs in cell culture model of Parkinson's disease: Relevance to α-synuclein misfolding in metal … DS Harischandra, S Ghaisas, D Rokad, M Zamanian, H Jin, ... Neurotoxicology 64, 267-277, 2018 | 85 | 2018 |
Role of neurotoxicants and traumatic brain injury in α-synuclein protein misfolding and aggregation D Rokad, S Ghaisas, DS Harischandra, H Jin, V Anantharam, ... Brain research bulletin 133, 60-70, 2017 | 60 | 2017 |
Manganese exposure exacerbates progressive motor deficits and neurodegeneration in the MitoPark mouse model of Parkinson’s disease: Relevance to gene and environment … MR Langley, S Ghaisas, M Ay, J Luo, BN Palanisamy, H Jin, ... Neurotoxicology 64, 240-255, 2018 | 56 | 2018 |
Exosomes in toxicology: relevance to chemical exposure and pathogenesis of environmentally linked diseases DS Harischandra, S Ghaisas, D Rokad, AG Kanthasamy Toxicological Sciences 158 (1), 3-13, 2017 | 50 | 2017 |
TRIM11 prevents and reverses protein aggregation and rescues a mouse model of Parkinson’s disease G Zhu, DS Harischandra, S Ghaisas, P Zhang, W Prall, L Huang, ... Cell reports 33 (9), 2020 | 44 | 2020 |
MitoPark transgenic mouse model recapitulates the gastrointestinal dysfunction and gut-microbiome changes of Parkinson’s disease S Ghaisas, MR Langley, BN Palanisamy, S Dutta, K Narayanaswamy, ... Neurotoxicology 75, 186-199, 2019 | 38 | 2019 |
Lasting retinal injury in a mouse model of blast-induced trauma N Mammadova, S Ghaisas, G Zenitsky, DS Sakaguchi, AG Kanthasamy, ... The American Journal of Pathology 187 (7), 1459-1472, 2017 | 34 | 2017 |
Enhanced differentiation of human dopaminergic neuronal cell model for preclinical translational research in Parkinson's disease DS Harischandra, D Rokad, S Ghaisas, S Verma, A Robertson, H Jin, ... Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1866 (4), 165533, 2020 | 28 | 2020 |
TRIM11 protects against tauopathies and is down-regulated in Alzheimer’s disease ZY Zhang, DS Harischandra, R Wang, S Ghaisas, JY Zhao, ... Science 381 (6656), eadd6696, 2023 | 22 | 2023 |
Characterization of nonmotor behavioral impairments and their neurochemical mechanisms in the MitoPark mouse model of progressive neurodegeneration in Parkinson's disease MR Langley, S Ghaisas, BN Palanisamy, M Ay, H Jin, V Anantharam, ... Experimental neurology 341, 113716, 2021 | 21 | 2021 |
Chronic Manganese Exposure and the Enteric Nervous System: An in Vitro and Mouse in Vivo Study S Ghaisas, DS Harischandra, B Palanisamy, A Proctor, H Jin, S Dutta, ... Environmental Health Perspectives 129 (8), 087005, 2021 | 12 | 2021 |
Chronic traumatic encephalopathy A Kanthasamy, V Anantharam, H Jin, S Ghaisas, G Zenitsky, ... Neuroimmune Pharmacology, 599-620, 2017 | 3 | 2017 |