Costas Lyssiotis
Costas Lyssiotis
Assistant Professor of Physiology, University of Michigan
Verified email at - Homepage
Cited by
Cited by
Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism
H Ying, AC Kimmelman, CA Lyssiotis, S Hua, GC Chu, ...
Cell 149 (3), 656-670, 2012
Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway
J Son, CA Lyssiotis, H Ying, X Wang, S Hua, M Ligorio, RM Perera, ...
Nature 496 (7443), 101-105, 2013
Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis
JW Locasale, AR Grassian, T Melman, CA Lyssiotis, KR Mattaini, AJ Bass, ...
Nature genetics 43 (9), 869-874, 2011
A colorectal cancer classification system that associates cellular phenotype and responses to therapy
A Sadanandam, CA Lyssiotis, K Homicsko, EA Collisson, WJ Gibb, ...
Nature medicine 19 (5), 619-625, 2013
Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function
A Viale, P Pettazzoni, CA Lyssiotis, H Ying, N Sánchez, M Marchesini, ...
Nature 514 (7524), 628-632, 2014
ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect
W Yang, Y Zheng, Y Xia, H Ji, X Chen, F Guo, CA Lyssiotis, K Aldape, ...
Nature cell biology 14 (12), 1295-1304, 2012
Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion
CM Sousa, DE Biancur, X Wang, CJ Halbrook, MH Sherman, L Zhang, ...
Nature 536 (7617), 479-483, 2016
Influence of threonine metabolism on S-adenosylmethionine and histone methylation
N Shyh-Chang, JW Locasale, CA Lyssiotis, Y Zheng, RY Teo, ...
Science 339 (6116), 222-226, 2013
Reprogramming of murine fibroblasts to induced pluripotent stem cells with chemical complementation of Klf4
CA Lyssiotis, RK Foreman, J Staerk, M Garcia, D Mathur, S Markoulaki, ...
Proceedings of the National Academy of Sciences 106 (22), 8912-8917, 2009
A regenerative approach to the treatment of multiple sclerosis
VA Deshmukh, V Tardif, CA Lyssiotis, CC Green, B Kerman, HJ Kim, ...
Nature 502 (7471), 327-332, 2013
Combining a PI3K inhibitor with a PARP inhibitor provides an effective therapy for BRCA1-related breast cancer
A Juvekar, LN Burga, H Hu, EP Lunsford, YH Ibrahim, J Balmañà, ...
Cancer discovery 2 (11), 1048-1063, 2012
Metabolic interactions in the tumor microenvironment
CA Lyssiotis, AC Kimmelman
Trends in cell biology 27 (11), 863-875, 2017
Oxidative stress controls regulatory T cell apoptosis and suppressor activity and PD-L1-blockade resistance in tumor
T Maj, W Wang, J Crespo, H Zhang, W Wang, S Wei, L Zhao, L Vatan, ...
Nature immunology 18 (12), 1332-1341, 2017
MUC1 and HIF-1alpha signaling crosstalk induces anabolic glucose metabolism to impart gemcitabine resistance to pancreatic cancer
SK Shukla, V Purohit, K Mehla, V Gunda, NV Chaika, E Vernucci, RJ King, ...
Cancer cell 32 (1), 71-87. e7, 2017
mTOR drives its own activation via SCFβTrCP-dependent degradation of the mTOR inhibitor DEPTOR
D Gao, H Inuzuka, MKM Tan, H Fukushima, JW Locasale, P Liu, L Wan, ...
Molecular cell 44 (2), 290-303, 2011
Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer
KL Bryant, CA Stalnecker, D Zeitouni, JE Klomp, S Peng, AP Tikunov, ...
Nature medicine 25 (4), 628-640, 2019
Dysregulated metabolism contributes to oncogenesis
MD Hirschey, RJ DeBerardinis, AME Diehl, JE Drew, C Frezza, MF Green, ...
Seminars in cancer biology 35, S129-S150, 2015
Designing a broad-spectrum integrative approach for cancer prevention and treatment
KI Block, C Gyllenhaal, L Lowe, A Amedei, ARMR Amin, A Amin, ...
Seminars in cancer biology 35, S276-S304, 2015
Phosphoinositide 3-kinase regulates glycolysis through mobilization of aldolase from the actin cytoskeleton
H Hu, A Juvekar, CA Lyssiotis, EC Lien, JG Albeck, D Oh, G Varma, ...
Cell 164 (3), 433-446, 2016
Employing metabolism to improve the diagnosis and treatment of pancreatic cancer
CJ Halbrook, CA Lyssiotis
Cancer cell 31 (1), 5-19, 2017
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