Efficient sensitivity analysis of large-scale differential-algebraic systems WF Feehery, JE Tolsma, PI Barton Applied Numerical Mathematics 25 (1), 41-54, 1997 | 307 | 1997 |
DAEPACK: An open modeling environment for legacy models J Tolsma, PI Barton Industrial & Engineering Chemistry Research 39 (6), 1826-1839, 2000 | 133 | 2000 |
Optimal design and operation of a natural gas tri-reforming reactor for DME synthesis W Cho, T Song, A Mitsos, JT McKinnon, GH Ko, JE Tolsma, D Denholm, ... Catalysis Today 139 (4), 261-267, 2009 | 132 | 2009 |
On upgrading the numerics in combustion chemistry codes DA Schwer, JE Tolsma, WH Green Jr, PI Barton Combustion and Flame 128 (3), 270-291, 2002 | 92 | 2002 |
Rigorous valid ranges for optimally reduced kinetic models OO Oluwole, B Bhattacharjee, JE Tolsma, PI Barton, WH Green Combustion and Flame 146 (1-2), 348-365, 2006 | 82 | 2006 |
On computational differentiation JE Tolsma, PI Barton Computers & chemical engineering 22 (4-5), 475-490, 1998 | 75 | 1998 |
Bridging the gap between in vitro and in vivo: dose and schedule predictions for the ATR inhibitor AZD6738 S Checkley, L MacCallum, J Yates, P Jasper, H Luo, J Tolsma, ... Scientific reports 5 (1), 1-12, 2015 | 68 | 2015 |
Rapid method to determine intracellular drug concentrations in cellular uptake assays: application to metformin in organic cation transporter 1–transfected human embryonic … HC Chien, AA Zur, TS Maurer, SW Yee, J Tolsma, P Jasper, DO Scott, ... Drug Metabolism and Disposition 44 (3), 356-364, 2016 | 61 | 2016 |
Hidden discontinuities and parametric sensitivity calculations JE Tolsma, PI Barton SIAM Journal on Scientific Computing 23 (6), 1861-1874, 2002 | 59 | 2002 |
Preclinical to clinical translation of antibody-drug conjugates using PK/PD modeling: a retrospective analysis of inotuzumab ozogamicin AM Betts, N Haddish-Berhane, J Tolsma, P Jasper, LE King, Y Sun, ... The AAPS journal 18, 1101-1116, 2016 | 54 | 2016 |
Construction of convex relaxations using automated code generation techniques EP Gatzke, JE Tolsma, PI Barton Optimization and Engineering 3, 305-326, 2002 | 52 | 2002 |
Symbolic incorporation of external procedures into process modeling environments JE Tolsma, JA Clabaugh, PI Barton Industrial & engineering chemistry research 41 (16), 3867-3876, 2002 | 49 | 2002 |
Quantitative systems pharmacology modeling of acid sphingomyelinase deficiency and the enzyme replacement therapy olipudase alfa is an innovative tool for linking … CD Kaddi, B Niesner, R Baek, P Jasper, J Pappas, J Tolsma, J Li, ... CPT: Pharmacometrics & Systems Pharmacology 7 (7), 442-452, 2018 | 27 | 2018 |
Computation of heteroazeotropes. Part I: Theory JE Tolsma, PI Barton Chemical engineering science 55 (18), 3817-3834, 2000 | 25 | 2000 |
Systems pharmacology model of gastrointestinal damage predicts species differences and optimizes clinical dosing schedules H Shankaran, A Cronin, J Barnes, P Sharma, J Tolsma, P Jasper, ... CPT: Pharmacometrics & Systems Pharmacology 7 (1), 26-33, 2018 | 20 | 2018 |
Use of translational modeling and simulation for quantitative comparison of PF-06804103, a new generation HER2 ADC, with Trastuzumab-DM1 A Betts, T Clark, P Jasper, J Tolsma, PH van der Graaf, EI Graziani, ... Journal of Pharmacokinetics and Pharmacodynamics 47, 513-526, 2020 | 18 | 2020 |
Computation of heteroazeotropes. Part II: Efficient calculation of changes in phase equilibrium structure JE Tolsma, PI Barton Chemical engineering science 55 (18), 3835-3853, 2000 | 18 | 2000 |
A quantitative systems pharmacology model of Gaucher disease type 1 provides mechanistic insight into the response to substrate reduction therapy with eliglustat R Abrams, CD Kaddi, M Tao, RJ Leiser, G Simoni, F Reali, J Tolsma, ... CPT: pharmacometrics & systems pharmacology 9 (7), 374-383, 2020 | 17 | 2020 |
A Physiologically‐Based Pharmacokinetic Model for the Prediction of “Half‐Life Extension” and “Catch and Release” Monoclonal Antibody Pharmacokinetics HM Jones, J Tolsma, Z Zhang, P Jasper, H Luo, GL Weber, K Wright, ... CPT: Pharmacometrics & Systems Pharmacology 9 (9), 534-541, 2020 | 14 | 2020 |
Efficient calculation of sparse Jacobians JE Tolsma, PI Barton SIAM Journal on Scientific Computing 20 (6), 2282-2296, 1999 | 13 | 1999 |