Frederic Checler
Frederic Checler
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Cited by
Cited by
Intraneuronal Aβ42 accumulation in human brain
GK Gouras, J Tsai, J Naslund, B Vincent, M Edgar, F Checler, ...
The American journal of pathology 156 (1), 15-20, 2000
Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain
D Moechars, I Dewachter, K Lorent, D Reversé, V Baekelandt, A Naidu, ...
Journal of Biological Chemistry 274 (10), 6483-6492, 1999
Estrogen reduces neuronal generation of Alzheimer β-amyloid peptides
H Xu, GK Gouras, JP Greenfield, B Vincent, J Naslund, L Mazzarelli, ...
Nature medicine 4 (4), 447-451, 1998
Amyloid precursor protein, presenilins, and α-synuclein: molecular pathogenesis and pharmacological applications in Alzheimer's disease
YH Suh, F Checler
Pharmacological reviews 54 (3), 469-525, 2002
Processing of the β‐amyloid precursor protein and its regulation in Alzheimer's disease
F Checler
Journal of neurochemistry 65 (4), 1431-1444, 1995
Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 …
A Herreman, D Hartmann, W Annaert, P Saftig, K Craessaerts, L Serneels, ...
Proceedings of the National Academy of Sciences 96 (21), 11872-11877, 1999
Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer β-amyloid peptides
JP Greenfield, J Tsai, GK Gouras, B Hai, G Thinakaran, F Checler, ...
Proceedings of the National Academy of Sciences 96 (2), 742-747, 1999
Transgenic mice with Alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation
DH Chui, H Tanahashi, K Ozawa, S Ikeda, F Checler, O Ueda, H Suzuki, ...
Nature medicine 5 (5), 560-564, 1999
Presenilin-dependent transcriptional control of the Aβ-degrading enzyme neprilysin by intracellular domains of βAPP and APLP
R Pardossi-Piquard, A Petit, T Kawarai, C Sunyach, CA Da Costa, ...
Neuron 46 (4), 541-554, 2005
TMP21 is a presenilin complex component that modulates γ-secretase but not ɛ-secretase activity
F Chen, H Hasegawa, G Schmitt-Ulms, T Kawarai, C Bohm, T Katayama, ...
Nature 440 (7088), 1208-1212, 2006
Post-translational processing of β-Secretase (β-Amyloid-converting Enzyme) and its ectodomain shedding the pro-and transmembrane/cytosolic domains affect its cellular activity …
S Benjannet, A Elagoz, L Wickham, M Mamarbachi, JS Munzer, A Basak, ...
Journal of Biological Chemistry 276 (14), 10879-10887, 2001
The disintegrins ADAM10 and TACE contribute to the constitutive and phorbol ester-regulated normal cleavage of the cellular prion protein
B Vincent, E Paitel, P Saftig, Y Frobert, D Hartmann, B De Strooper, ...
Journal of Biological Chemistry 276 (41), 37743-37746, 2001
Intracellular Aβ42 activates p53 promoter: a pathway to neurodegeneration in Alzheimer's disease
Y Ohyagi, H Asahara, DH Chui, Y Tsuruta, N Sakae, K Miyoshi, T Yamada, ...
The FASEB Journal 19 (2), 1-29, 2005
Phenotype associated with APP duplication in five families
L Cabrejo, L Guyant-Maréchal, A Laquerrière, M Vercelletto, ...
Brain 129 (11), 2966-2976, 2006
Wild-type but not Parkinson's disease-related ala-53→ Thr mutant α-synuclein protects neuronal cells from apoptotic stimuli
CA da Costa, K Ancolio, F Checler
Journal of Biological Chemistry 275 (31), 24065-24069, 2000
New protease inhibitors prevent γ-secretase-mediated production of Aβ40/42 without affecting Notch cleavage
A Petit, F Bihel, CA da Costa, O Pourquié, F Checler, JL Kraus
Nature cell biology 3 (5), 507-511, 2001
Unusual phenotypic alteration of β amyloid precursor protein (βAPP) maturation by a new Val-715→ Met βAPP-770 mutation responsible for probable early-onset Alzheimer’s disease
K Ancolio, C Dumanchin, H Barelli, JM Warter, A Brice, D Campion, ...
Proceedings of the National Academy of Sciences 96 (7), 4119-4124, 1999
Prominent cerebral amyloid angiopathy in transgenic mice overexpressing the London mutant of human APP in neurons
J Van Dorpe, L Smeijers, I Dewachter, D Nuyens, K Spittaels, ...
The American journal of pathology 157 (4), 1283-1298, 2000
Pathogenic APP mutations near the γ-secretase cleavage site differentially affect Aβ secretion and APP C-terminal fragment stability
C De Jonghe, C Esselens, S Kumar-Singh, K Craessaerts, S Serneels, ...
Human molecular genetics 10 (16), 1665-1671, 2001
Pharmacology and biochemistry of neurotensin receptors.
P Kitabgi, F Checler, J Mazella, JP Vincent
Reviews in clinical & basic pharmacology 5 (3-4), 397-486, 1985
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