Cloning, expression, and type II collagenolytic activity of matrix metalloproteinase-13 from human osteoarthritic cartilage. PG Mitchell, HA Magna, LM Reeves, LL Lopresti-Morrow, SA Yocum, ... The Journal of clinical investigation 97 (3), 761-768, 1996 | 1192 | 1996 |
Identification, characterization, and crystal structure of the Omega class glutathione transferases PG Board, M Coggan, G Chelvanayagam, S Easteal, LS Jermiin, ... Journal of Biological Chemistry 275 (32), 24798-24806, 2000 | 911 | 2000 |
Structural basis of latency in plasminogen activator inhibitor-1 J Mottonen, A Strand, J Symersky, RM Sweet, DE Danley, KF Geoghegan, ... Nature 355 (6357), 270-273, 1992 | 695 | 1992 |
Site-directed conjugation of nonpeptide groups to peptides and proteins via periodate oxidation of a 2-amino alcohol. Application to modification at N-terminal serine KF Geoghegan, JG Stroh Bioconjugate chemistry 3 (2), 138-146, 1992 | 684 | 1992 |
X-ray analysis of HIV-1 proteinase at 2.7 Å resolution confirms structural homology among retroviral enzymes R Lapatto, T Blundell, A Hemmings, J Overington, A Wilderspin, S Wood, ... Nature 342 (6247), 299-302, 1989 | 611 | 1989 |
Structural and biophysical studies of PCSK9 and its mutants linked to familial hypercholesterolemia D Cunningham, DE Danley, KF Geoghegan, MC Griffor, JL Hawkins, ... Nature structural & molecular biology 14 (5), 413-419, 2007 | 560 | 2007 |
Crystal structure of cholesteryl ester transfer protein reveals a long tunnel and four bound lipid molecules X Qiu, A Mistry, MJ Ammirati, BA Chrunyk, RW Clark, Y Cong, JS Culp, ... Nature structural & molecular biology 14 (2), 106-113, 2007 | 321 | 2007 |
Spontaneous α-N-6-Phosphogluconoylation of a “His Tag” inEscherichia coli: The Cause of Extra Mass of 258 or 178 Da in Fusion Proteins KF Geoghegan, HBF Dixon, PJ Rosner, LR Hoth, AJ Lanzetti, ... Analytical biochemistry 267 (1), 169-184, 1999 | 309 | 1999 |
Kinetic analysis of estrogen receptor/ligand interactions RL Rich, LR Hoth, KF Geoghegan, TA Brown, PK LeMotte, SP Simons, ... Proceedings of the National Academy of Sciences 99 (13), 8562-8567, 2002 | 301 | 2002 |
Glutathione S-Transferase Omega 1-1 Is a Target of Cytokine Release Inhibitory Drugs and May Be Responsible for Their Effect on Interleukin-1औ Posttranslational Processing RE Laliberte, DG Perregaux, LR Hoth, PJ Rosner, CK Jordan, KM Peese, ... Journal of Biological Chemistry 278 (19), 16567-16578, 2003 | 247 | 2003 |
Modified peptide derivatives conjugated at 2-hydroxyethylamine moieties KF Geoghegan US Patent 5,362,852, 1994 | 199 | 1994 |
Structural basis for AMPK activation: natural and synthetic ligands regulate kinase activity from opposite poles by different molecular mechanisms MF Calabrese, F Rajamohan, MS Harris, NL Caspers, R Magyar, ... Structure 22 (8), 1161-1172, 2014 | 181 | 2014 |
IL-1 beta maturation: evidence that mature cytokine formation can be induced specifically by nigericin. D Perregaux, J Barberia, AJ Lanzetti, KF Geoghegan, TJ Carty, CA Gabel Journal of immunology (Baltimore, Md.: 1950) 149 (4), 1294-1303, 1992 | 181 | 1992 |
X-ray analyses of peptide–inhibitor complexes define the structural basis of specificity for human and mouse renins V Dhanaraj, CG Dealwis, C Frazao, M Badasso, BL Sibanda, IJ Tickle, ... Nature 357 (6378), 466-472, 1992 | 174 | 1992 |
Rational targeting of active-site tyrosine residues using sulfonyl fluoride probes EC Hett, H Xu, KF Geoghegan, A Gopalsamy, RE Kyne Jr, CA Menard, ... ACS Chemical Biology 10 (4), 1094-1098, 2015 | 165 | 2015 |
Concentration-dependent modulation of amyloid-β in vivo and in vitro using the γ-secretase inhibitor, LY-450139 TA Lanz, MJ Karmilowicz, KM Wood, N Pozdnyakov, P Du, MA Piotrowski, ... Journal of Pharmacology and Experimental Therapeutics 319 (2), 924-933, 2006 | 157 | 2006 |
Discovery of a JAK3-selective inhibitor: functional differentiation of JAK3-selective inhibition over pan-JAK or JAK1-selective inhibition JB Telliez, ME Dowty, LU Wang, J Jussif, T Lin, L Li, E Moy, P Balbo, W Li, ... ACS chemical biology 11 (12), 3442-3451, 2016 | 149 | 2016 |
Pharmacologic inhibition of site 1 protease activity inhibits sterol regulatory element-binding protein processing and reduces lipogenic enzyme gene expression and lipid … JL Hawkins, MD Robbins, LC Warren, D Xia, SF Petras, JJ Valentine, ... Journal of Pharmacology and Experimental Therapeutics 326 (3), 801-808, 2008 | 147 | 2008 |
Prolonged delivery of peptides Y Kim, WJ Lambert, H Qi, RA Gelfand, KF Geoghegan, DE Danley US Patent 6,284,727, 2001 | 143 | 2001 |
Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain NG Lintner, KF McClure, D Petersen, AT Londregan, DW Piotrowski, ... PLoS biology 15 (3), e2001882, 2017 | 130 | 2017 |