Paul Czodrowski
Paul Czodrowski
Professor for Computational Chemical Biology
tu-dortmund.de üzerinde doğrulanmış e-posta adresine sahip - Ana Sayfa
Başlık
Alıntı yapanlar
Alıntı yapanlar
Yıl
PDB2PQR: expanding and upgrading automated preparation of biomolecular structures for molecular simulations
TJ Dolinsky, P Czodrowski, H Li, JE Nielsen, JH Jensen, G Klebe, ...
Nucleic acids research 35 (suppl_2), W522-W525, 2007
16032007
Applications of machine learning in drug discovery and development
J Vamathevan, D Clark, P Czodrowski, I Dunham, E Ferran, G Lee, B Li, ...
Nature Reviews Drug Discovery 18 (6), 463-477, 2019
5142019
A selective chemical probe for exploring the role of CDK8 and CDK19 in human disease
T Dale, PA Clarke, C Esdar, D Waalboer, O Adeniji-Popoola, ...
Nature chemical biology 11 (12), 973, 2015
892015
Discovery of potent, selective, and orally bioavailable small-molecule modulators of the mediator complex-associated kinases CDK8 and CDK19
A Mallinger, K Schiemann, C Rink, F Stieber, M Calderini, S Crumpler, ...
Journal of medicinal chemistry 59 (3), 1078-1101, 2016
792016
Protonation changes upon ligand binding to trypsin and thrombin: structural interpretation based on pKa calculations and ITC experiments
P Czodrowski, CA Sotriffer, G Klebe
Journal of molecular biology 367 (5), 1347-1356, 2007
782007
TRAPP: A Tool for Analysis of Transient Binding Pockets in Proteins
DB Kokh, S Richter, S Henrich, P Czodrowski, F Rippmann, RC Wade
Journal of chemical information and modeling 53 (5), 1235-1252, 2013
642013
Development, validation, and application of adapted PEOE charges to estimate pKa values of functional groups in protein–ligand complexes
P Czodrowski, I Dramburg, CA Sotriffer, G Klebe
Proteins: Structure, Function, and Bioinformatics 65 (2), 424-437, 2006
622006
Structure-based optimization of potent, selective, and orally bioavailable CDK8 inhibitors discovered by high-throughput screening
P Czodrowski, A Mallinger, D Wienke, C Esdar, O Pöschke, M Busch, ...
Journal of medicinal chemistry 59 (20), 9337-9349, 2016
612016
Computational approaches to predict drug metabolism
P Czodrowski, JM Kriegl, S Scheuerer, T Fox
Expert opinion on drug metabolism & toxicology 5 (1), 15-27, 2009
532009
hERG me out
P Czodrowski
Journal of chemical information and modeling 53 (9), 2240-2251, 2013
512013
Structure of the epimerization domain of tyrocidine synthetase A
SA Samel, P Czodrowski, LO Essen
Acta Crystallographica Section D: Biological Crystallography 70 (5), 1442-1452, 2014
482014
The mid-region of parathyroid hormone (1− 34) serves as a functional docking domain in receptor activation
A Wittelsberger, M Corich, BE Thomas, BK Lee, A Barazza, P Czodrowski, ...
Biochemistry 45 (7), 2027-2034, 2006
472006
Tracing changes in protonation: a prerequisite to factorize thermodynamic data of inhibitor binding to aldose reductase
H Steuber, P Czodrowski, CA Sotriffer, G Klebe
Journal of molecular biology 373 (5), 1305-1320, 2007
432007
Atypical protonation states in the active site of HIV-1 protease: a computational study
P Czodrowski, CA Sotriffer, G Klebe
Journal of chemical information and modeling 47 (4), 1590-1598, 2007
412007
Large-scale assessment of binding free energy calculations in active drug discovery projects
CEM Schindler, H Baumann, A Blum, D Böse, HP Buchstaller, ...
Journal of Chemical Information and Modeling 60 (11), 5457-5474, 2020
402020
Measurement of the cross-section and charge asymmetry of W bosons produced in proton–proton collisions at s=8TeV with the ATLAS detector
G Aad, B Abbott, DC Abbott, AA Abud, K Abeling, DK Abhayasinghe, ...
The European Physical Journal C 79 (9), 1-25, 2019
362019
2, 8-Disubstituted-1, 6-naphthyridines and 4, 6-disubstituted-isoquinolines with potent, selective affinity for CDK8/19
A Mallinger, K Schiemann, C Rink, J Sejberg, MA Honey, P Czodrowski, ...
ACS medicinal chemistry letters 7 (6), 573-578, 2016
342016
Discovery of potent and selective CDK8 inhibitors from an HSP90 pharmacophore
K Schiemann, A Mallinger, D Wienke, C Esdar, O Poeschke, M Busch, ...
Bioorganic & medicinal chemistry letters 26 (5), 1443-1451, 2016
342016
Search for W′→ tb→ qqbb decays in pp collisions at s= 8 TeV with the ATLAS detector
G Aad, B Abbott, J Abdallah, SA Khalek, R Aben, B Abi, M Abolins, ...
The European Physical Journal C 75 (4), 1-23, 2015
242015
Chasing Protons: How Isothermal Titration Calorimetry, Mutagenesis, and pKa Calculations Trace the Locus of Charge in Ligand Binding to a tRNA-Binding Enzyme
M Neeb, P Czodrowski, A Heine, LJ Barandun, C Hohn, F Diederich, ...
Journal of medicinal chemistry 57 (13), 5554-5565, 2014
242014
Sistem, işlemi şu anda gerçekleştiremiyor. Daha sonra yeniden deneyin.
Makaleler 1–20