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Lauren L Orefice
Lauren L Orefice
Assistant Professor, Harvard Medical School and Massachusetts General Hospital
Verified email at hms.harvard.edu - Homepage
Title
Cited by
Cited by
Year
The cellular and synaptic architecture of the mechanosensory dorsal horn
VE Abraira, ED Kuehn, AM Chirila, MW Springel, AA Toliver, ...
Cell 168 (1), 295-310. e19, 2017
3612017
Peripheral mechanosensory neuron dysfunction underlies tactile and behavioral deficits in mouse models of ASDs
LL Orefice, AL Zimmerman, AM Chirila, SJ Sleboda, JP Head, DD Ginty
Cell 166 (2), 299-313, 2016
3572016
BDNF promotes differentiation and maturation of adult-born neurons through GABAergic transmission
EG Waterhouse, JJ An, LL Orefice, M Baydyuk, GY Liao, K Zheng, B Lu, ...
Journal of Neuroscience 32 (41), 14318-14330, 2012
3272012
Targeting peripheral somatosensory neurons to improve tactile-related phenotypes in ASD models
LL Orefice, JR Mosko, DT Morency, MF Wells, A Tasnim, SM Mozeika, ...
Cell 178 (4), 867-886. e24, 2019
1862019
DeepEthogram, a machine learning pipeline for supervised behavior classification from raw pixels
JP Bohnslav, NK Wimalasena, KJ Clausing, YY Dai, DA Yarmolinsky, ...
Elife 10, e63377, 2021
1162021
Distinct roles for somatically and dendritically synthesized brain-derived neurotrophic factor in morphogenesis of dendritic spines
LL Orefice, EG Waterhouse, JG Partridge, RR Lalchandani, S Vicini, B Xu
Journal of Neuroscience 33 (28), 11618-11632, 2013
1062013
Meissner corpuscles and their spatially intermingled afferents underlie gentle touch perception
NL Neubarth, AJ Emanuel, Y Liu, MW Springel, A Handler, Q Zhang, ...
Science 368 (6497), eabb2751, 2020
1052020
Hypoxia rescues frataxin loss by restoring iron sulfur cluster biogenesis
T Ast, JD Meisel, S Patra, H Wang, RMH Grange, SH Kim, SE Calvo, ...
Cell 177 (6), 1507-1521. e16, 2019
932019
Wnt5a is essential for hippocampal dendritic maintenance and spatial learning and memory in adult mice
CM Chen, LL Orefice, SL Chiu, TA LeGates, S Hattar, RL Huganir, H Zhao, ...
Proceedings of the National Academy of Sciences 114 (4), E619-E628, 2017
802017
Control of spine maturation and pruning through proBDNF synthesized and released in dendrites
LL Orefice, CC Shih, H Xu, EG Waterhouse, B Xu
Molecular and Cellular Neuroscience 71, 66-79, 2016
582016
Peripheral somatosensory neuron dysfunction: emerging roles in autism spectrum disorders
LL Orefice
Neuroscience 445, 120-129, 2020
332020
Neural, endocrine and electroencephalographic hyperreactivity to human contact: a diathesis-stress model of seizure susceptibility in El mice
PA Forcelli, LL Orefice, SC Heinrichs
Brain research 1144, 248-256, 2007
242007
Paternal care paradoxically increases offspring seizure susceptibility in the El mouse model of epilepsy
LL Orefice, SC Heinrichs
Epilepsy & Behavior 12 (2), 234-241, 2008
122008
Outside-in: rethinking the etiology of autism spectrum disorders
LL Orefice
Science 366 (6461), 45-46, 2019
92019
Methods and compositions for reducing tactile dysfunction and anxiety associated with autism spectrum disorder, Rett syndrome, and Fragile X syndrome
LL Orefice, DD Ginty
US Patent 11,547,706, 2023
52023
The developmental timing of spinal touch processing alterations predicts behavioral changes in genetic mouse models of autism spectrum disorders
A Tasnim, I Alkislar, R Hakim, J Turecek, A Abdelaziz, LL Orefice, ...
Nature Neuroscience, 1-13, 2024
22024
Emerging Therapeutic Strategies for Fragile X Syndrome: Q&A
G Alusi, E Berry-Kravis, D Nelson, LL Orefice, SA Booker
ACS Chemical Neuroscience 13 (24), 3544-3546, 2022
22022
Compositions and methods for reducing tactile dysfunction, anxiety, and social impairment
DD Ginty, LL Orefice, J Lee
US Patent App. 17/056,069, 2021
22021
The developmental timing of spinal touch processing alterations and its relation to ASD-associated behaviors in mouse models
A Tasnim, I Alkislar, R Hakim, J Turecek, A Abdelaziz, LL Orefice, ...
bioRxiv, 2023.05. 09.539589, 2023
12023
Compositions and methods for reducing tactile dysfunction, anxiety, and social impairment
DD Ginty, LL Orefice, J Lee
US Patent 11,434,244, 2022
12022
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