Tim Hardingham
Tim Hardingham
Wellcome Trust Centre for Cell-Matrix Research, University of Manchester, UK
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Cited by
Cited by
Proteoglycans: many forms and many functions
TE Hardingham, AJ Fosang
The FASEB journal 6 (3), 861-870, 1992
The specific interaction of hyaluronic acid with cartilage proteoglycans
TE Hardingham, H Muir
Biochimica et Biophysica Acta (BBA)-General Subjects 279 (2), 401-405, 1972
The role of link-protein in the structure of cartilage proteoglycan aggregates
TE Hardingham
Biochemical Journal 177 (1), 237-247, 1979
Hyaluronic acid in cartilage and proteoglycan aggregation
TE Hardingham, H Muir
Biochemical Journal 139 (3), 565-581, 1974
The interglobular domain of cartilage aggrecan is cleaved by PUMP, gelatinases, and cathepsin B.
AJ Fosang, PJ Neame, K Last, TE Hardingham, G Murphy, JA Hamilton
Journal of Biological Chemistry 267 (27), 19470-19474, 1992
Directed differentiation of human embryonic stem cells toward chondrocytes
RA Oldershaw, MA Baxter, ET Lowe, N Bates, LM Grady, F Soncin, ...
Nature biotechnology 28 (11), 1187-1194, 2010
Proteoglycans of articular cartilage: changes in aging and in joint disease
T Hardingham, M Bayliss
Seminars in arthritis and rheumatism 20 (3), 12-33, 1990
Chondrogenic differentiation of human bone marrow stem cells in transwell cultures: generation of scaffold-free cartilage
AD Murdoch, LM Grady, MP Ablett, T Katopodi, RS Meadows, ...
Stem cells 25 (11), 2786-2796, 2007
Modulation of native chondroitin sulphate structure in tissue development and in disease
B Caterson, F Mahmoodian, JM Sorrell, TE Hardingham, MT Bayliss, ...
Journal of cell science 97 (3), 411-417, 1990
Biosynthesis of proteoglycans and their assembly into aggregates in cultures of chondrocytes from the Swarm rat chondrosarcoma.
JH Kimura, TE Hardingham, VC Hascall, M Solursh
Journal of Biological Chemistry 254 (8), 2600-2609, 1979
Hypoxic conditions increase hypoxia-inducible transcription factor 2α and enhance chondrogenesis in stem cells from the infrapatellar fat pad of osteoarthritis patients
WS Khan, AB Adesida, TE Hardingham
Arthritis research & therapy 9, 1-9, 2007
Tissue engineering: chondrocytes and cartilage
T Hardingham, S Tew, A Murdoch
Arthritis Research & Therapy 4, 1-6, 2002
Cartilage proteoglycans. Structure and heterogeneity of the protein core and the effects of specific protein modifications on the binding to hyaluronate
TE Hardingham, RJF Ewins, H Muir
Biochemical Journal 157 (1), 127-143, 1976
Binding of oligosaccharides of hyaluronic acid to proteoglycans
TE Hardingham, H MuIR
Biochemical Journal 135 (4), 905, 1973
Proteoglycans: their structure, interactions and molecular organization in cartilage
T Hardingham
Biochemical Society Transactions 9 (6), 489-497, 1981
Retroviral transduction with SOX9 enhances re-expression of the chondrocyte phenotype in passaged osteoarthritic human articular chondrocytes
SR Tew, Y Li, P Pothacharoen, LM Tweats, RE Hawkins, TE Hardingham
Osteoarthritis and cartilage 13 (1), 80-89, 2005
Cleavage of cartilage proteoglycan between G1 and G2 domains by stromelysins
AJ Fosang, PJ Neame, TE Hardingham, G Murphy, JA Hamilton
Journal of Biological Chemistry 266 (24), 15579-15582, 1991
Cartilage, SOX9 and Notch signals in chondrogenesis
TE Hardingham, RA Oldershaw, SR Tew
Journal of anatomy 209 (4), 469-480, 2006
Fibroblast and neutrophil collagenases cleave at two sites in the cartilage aggrecan interglobular domain
AJ Fosang, K Last, V Knäuper, PJ Neame, G Murphy, TE Hardingham, ...
Biochemical Journal 295 (1), 273-276, 1993
Calcium-dependent protein interactions in MUC5B provide reversible cross-links in salivary mucus
BDE Raynal, TE Hardingham, JK Sheehan, DJ Thornton
Journal of Biological Chemistry 278 (31), 28703-28710, 2003
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