Rotem Karni
Rotem Karni
Associate Professor, Biochemistry and Molecular Biology, Hebrew University-Hadassah Medical School
Verified email at - Homepage
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Cited by
The gene encoding the splicing factor SF2/ASF is a proto-oncogene
R Karni, E de Stanchina, SW Lowe, R Sinha, D Mu, AR Krainer
Nature structural & molecular biology 14 (3), 185-193, 2007
The splicing factor SRSF1 regulates apoptosis and proliferation to promote mammary epithelial cell transformation
O Anczuków, AZ Rosenberg, M Akerman, S Das, L Zhan, R Karni, ...
Nature structural & molecular biology 19 (2), 220, 2012
Control of pancreatic β cell regeneration by glucose metabolism
S Porat, N Weinberg-Corem, S Tornovsky-Babaey, R Schyr-Ben-Haroush, ...
Cell metabolism 13 (4), 440-449, 2011
Inhibition of pp60 c-Src reduces Bcl-X L expression and reverses the transformed phenotype of cells overexpressing EGF and HER-2 receptors
R Karni, R Jove, A Levitzki
Oncogene 18 (33), 4654-4662, 1999
Splicing factor hnRNP A2/B1 regulates tumor suppressor gene splicing and is an oncogenic driver in glioblastoma
R Golan-Gerstl, M Cohen, A Shilo, SS Suh, A Bakącs, L Coppola, R Karni
Cancer research 71 (13), 4464-4472, 2011
SF2/ASF autoregulation involves multiple layers of post-transcriptional and translational control
S Sun, Z Zhang, R Sinha, R Karni, AR Krainer
Nature structural & molecular biology 17 (3), 306, 2010
Long noncoding RNA MALAT1 promotes hepatocellular carcinoma development by SRSF1 upregulation and mTOR activation
P Malakar, A Shilo, A Mogilevsky, I Stein, E Pikarsky, Y Nevo, ...
Cancer research 77 (5), 1155-1167, 2017
Activated pp60c-Src leads to elevated hypoxia-inducible factor (HIF)-1α expression under normoxia
R Karni, Y Dor, E Keshet, O Meyuhas, A Levitzki
Journal of Biological Chemistry 277 (45), 42919-42925, 2002
The splicing-factor oncoprotein SF2/ASF activates mTORC1
R Karni, Y Hippo, SW Lowe, AR Krainer
Proceedings of the National Academy of Sciences 105 (40), 15323-15327, 2008
Identification of recurrent regulated alternative splicing events across human solid tumors
M Danan-Gotthold, R Golan-Gerstl, E Eisenberg, K Meir, R Karni, ...
Nucleic acids research 43 (10), 5130-5144, 2015
Functional and prognostic significance of long non-coding RNA MALAT1 as a metastasis driver in ER negative lymph node negative breast cancer
M Jadaliha, X Zong, P Malakar, T Ray, DK Singh, SM Freier, T Jensen, ...
Oncotarget 7 (26), 40418, 2016
Tumour ischaemia by interferon-γ resembles physiological blood vessel regression
T Kammertoens, C Friese, A Arina, C Idel, D Briesemeister, M Rothe, ...
Nature 545 (7652), 98-102, 2017
The pp60c-Src inhibitor PP1 is non-competitive against ATP
R Karni, S Mizrachi, E Reiss-Sklan, A Gazit, O Livnah, A Levitzki
FEBS letters 537 (1-3), 47-52, 2003
The splicing factor SRSF6 is amplified and is an oncoprotein in lung and colon cancers
M Cohen‐Eliav, R Golan‐Gerstl, Z Siegfried, CL Andersen, K Thorsen, ...
The Journal of Pathology 229 (4), 630-639, 2013
Arginine methylation controls the subcellular localization and functions of the oncoprotein splicing factor SF2/ASF
R Sinha, E Allemand, Z Zhang, R Karni, MP Myers, AR Krainer
Molecular and cellular biology 30 (11), 2762-2774, 2010
S6K1 alternative splicing modulates its oncogenic activity and regulates mTORC1
V Ben-Hur, P Denichenko, Z Siegfried, A Maimon, A Krainer, B Davidson, ...
Cell reports 3 (1), 103-115, 2013
Alternative splicing of SLC39A14 in colorectal cancer is regulated by the Wnt pathway
K Thorsen, F Mansilla, T Schepeler, B Ųster, MH Rasmussen, L Dyrskjųt, ...
Molecular & Cellular Proteomics 10 (1), 2011
Active Src elevates the expression of β-catenin by enhancement of cap-dependent translation
R Karni, Y Gus, Y Dor, O Meyuhas, A Levitzki
Molecular and cellular biology 25 (12), 5031-5039, 2005
Splicing factor hnRNP A2 activates the Ras-MAPK-ERK pathway by controlling A-Raf splicing in hepatocellular carcinoma development
A Shilo, VB Hur, P Denichenko, I Stein, E Pikarsky, J Rauch, W Kolch, ...
Rna 20 (4), 505-515, 2014
Mnk2 alternative splicing modulates the p38-MAPK pathway and impacts Ras-induced transformation
A Maimon, M Mogilevsky, A Shilo, R Golan-Gerstl, A Obiedat, V Ben-Hur, ...
Cell reports 7 (2), 501-513, 2014
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