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| MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool H Gad, T Koolmeister, AS Jemth, S Eshtad, SA Jacques, CE Ström, ... Nature 508 (7495), 215-221, 2014 | 533 | 2014 |
| Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy KVM Huber, E Salah, B Radic, M Gridling, JM Elkins, A Stukalov, ... Nature 508 (7495), 222-227, 2014 | 437 | 2014 |
| Glutathione transferases catalyse the detoxication of oxidized metabolites (o-quinones) of catecholamines and may serve as an antioxidant system preventing degenerative … S Baez, J Segura-Aguilar, M Widersten, AS Johansson, B Mannervik Biochemical Journal 324 (1), 25-28, 1997 | 431 | 1997 |
| Differences in the catalytic efficiencies of allelic variants of glutathione transferase P1-1 towards carcinogenic diol epoxides of polycyclic aromatic hydrocarbons. K Sundberg, AS Johansson, G Stenberg, M Widersten, A Seidel, ... Carcinogenesis 19 (3), 433-436, 1998 | 428 | 1998 |
| Human glutathione transferase A3-3, a highly efficient catalyst of double-bond isomerization in the biosynthetic pathway of steroid hormones AS Johansson, B Mannervik Journal of biological chemistry 276 (35), 33061-33065, 2001 | 276 | 2001 |
| Structure-activity relationships and thermal stability of human glutathione transferase P1-1 governed by the H-site residue 105 AS Johansson, G Stenberg, M Widersten, B Mannervik Journal of molecular biology 278 (3), 687-698, 1998 | 225 | 1998 |
| PARP-3 is a mono-ADP-ribosylase that activates PARP-1 in the absence of DNA O Loseva, AS Jemth, HE Bryant, H Schüler, L Lehtiö, T Karlberg, ... Journal of Biological Chemistry 285 (11), 8054-8060, 2010 | 202 | 2010 |
| Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation T Visnes, A Cázares-Körner, W Hao, O Wallner, G Masuyer, O Loseva, ... Science 362 (6416), 834-839, 2018 | 191 | 2018 |
| Processing of protein ADP-ribosylation by Nudix hydrolases L Palazzo, B Thomas, AS Jemth, T Colby, O Leidecker, KLH Feijs, R Zaja, ... Biochemical Journal 468 (2), 293-301, 2015 | 140 | 2015 |
| Validation and development of MTH1 inhibitors for treatment of cancer UW Berglund, K Sanjiv, H Gad, C Kalderen, T Koolmeister, T Pham, ... Annals of oncology 27 (12), 2275-2283, 2016 | 139 | 2016 |
| A comprehensive structural, biochemical and biological profiling of the human NUDIX hydrolase family J Carreras-Puigvert, M Zitnik, AS Jemth, M Carter, JE Unterlass, ... Nature communications 8 (1), 1541, 2017 | 137 | 2017 |
| CyDNA: synthesis and replication of highly Cy-dye substituted DNA by an evolved polymerase N Ramsay, AS Jemth, A Brown, N Crampton, P Dear, P Holliger Journal of the American Chemical Society 132 (14), 5096-5104, 2010 | 134 | 2010 |
| Glutathione transferase M2-2 catalyzes conjugation of dopamine and dopa o-quinones A Dagnino-Subiabre, BK Cassels, S Baez, AS Johansson, B Mannervik, ... Biochemical and biophysical research communications 274 (1), 32-36, 2000 | 132 | 2000 |
| Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies N Herold, SG Rudd, L Ljungblad, K Sanjiv, IH Myrberg, CBJ Paulin, ... Nature medicine 23 (2), 256-263, 2017 | 121 | 2017 |
| Crystal structure, biochemical and cellular activities demonstrate separate functions of MTH1 and MTH2 M Carter, AS Jemth, A Hagenkort, BDG Page, R Gustafsson, JJ Griese, ... Nature communications 6 (1), 7871, 2015 | 119 | 2015 |
| Structural basis for inhibitor specificity in human poly (ADP-ribose) polymerase-3 L Lehtio, AS Jemth, R Collins, O Loseva, A Johansson, N Markova, ... Journal of medicinal chemistry 52 (9), 3108-3111, 2009 | 115 | 2009 |
| NUDT15 hydrolyzes 6-thio-deoxyGTP to mediate the anticancer efficacy of 6-thioguanine NCK Valerie, A Hagenkort, BDG Page, G Masuyer, D Rehling, M Carter, ... Cancer research 76 (18), 5501-5511, 2016 | 109 | 2016 |
| Crystal structure of human MTH1 and the 8-oxo-dGMP product complex LM Svensson, AS Jemth, M Desroses, O Loseva, T Helleday, M Högbom, ... FEBS letters 585 (16), 2617-2621, 2011 | 91 | 2011 |
| Transmutation of human glutathione transferase A2-2 with peroxidase activity into an efficient steroid isomerase PL Pettersson, AS Johansson, B Mannervik Journal of Biological Chemistry 277 (33), 30019-30022, 2002 | 79 | 2002 |
