Rafael Couñago
Rafael Couñago
Structural Genomics Consortium - UNICAMP
Verified email at unicamp.br - Homepage
Title
Cited by
Cited by
Year
In vivo molecular evolution reveals biophysical origins of organismal fitness
R Couñago, S Chen, Y Shamoo
Molecular cell 22 (4), 441-449, 2006
1082006
Evolution of the B3 DNA binding superfamily: new insights into REM family gene diversification
EAC Romanel, CG Schrago, RM Couñago, CAM Russo, M Alves-Ferreira
PloS one 4 (6), e5791, 2009
1042009
Imperfect coordination chemistry facilitates metal ion release in the Psa permease
RM Couñago, MP Ween, SL Begg, M Bajaj, J Zuegg, ML O'mara, ...
Nature chemical biology 10 (1), 35-41, 2014
972014
Dysregulation of transition metal ion homeostasis is the molecular basis for cadmium toxicity in Streptococcus pneumoniae
SL Begg, BA Eijkelkamp, Z Luo, RM Couñago, JR Morey, MJ Maher, ...
Nature communications 6 (1), 1-11, 2015
762015
AdcA and AdcAII employ distinct zinc acquisition mechanisms and contribute additively to zinc homeostasis in Streptococcus pneumoniae
CD Plumptre, BA Eijkelkamp, JR Morey, F Behr, RM Couñago, ...
Molecular microbiology 91 (4), 834-851, 2014
702014
Crystal Structure of Rice Importin-α and Structural Basis of Its Interaction with Plant-Specific Nuclear Localization Signals
CW Chang, RLM Couñago, SJ Williams, M Bodén, B Kobe
The Plant Cell 24 (12), 5074-5088, 2012
482012
Distinctive conformation of minor site‐specific nuclear localization signals bound to Importin‐α
CW Chang, RM Couñago, SJ Williams, M Bodén, B Kobe
Traffic 14 (11), 1144-1154, 2013
442013
An adaptive mutation in adenylate kinase that increases organismal fitness is linked to stability–activity trade-offs
R Counago, CJ Wilson, MI Pena, P Wittung-Stafshede, Y Shamoo
Protein Engineering, Design & Selection 21 (1), 19-27, 2008
402008
Gene replacement of adenylate kinase in the gram-positive thermophile Geobacillus stearothermophilus disrupts adenine nucleotide homeostasis and reduces cell viability
R Counago, Y Shamoo
Extremophiles 9 (2), 135-144, 2005
332005
Biochemical and structural characterization of alanine racemase from Bacillus anthracis (Ames)
RM Couñago, M Davlieva, U Strych, RE Hill, KL Krause
BMC structural biology 9 (1), 1-15, 2009
322009
Prokaryotic substrate-binding proteins as targets for antimicrobial therapies.
RL Couñago, CA McDevitt, MP Ween, B Kobe
Current drug targets 13 (11), 1400-10., 2012
312012
Novel bacterial MerR-like regulators: Their role in the response to carbonyl and nitrosative stress
AG McEwan, KY Djoko, NH Chen, RLM Counago, SP Kidd, AJ Potter, ...
Advances in microbial physiology 58, 1-22, 2011
272011
Experimental evolution of adenylate kinase reveals contrasting strategies toward protein thermostability
C Miller, M Davlieva, C Wilson, KI White, R Couñago, G Wu, JC Myers, ...
Biophysical journal 99 (3), 887-896, 2010
232010
A glutathione-dependent detoxification system is required for formaldehyde resistance and optimal survival of Neisseria meningitidis in biofilms
NH Chen, RM Couñago, KY Djoko, MP Jennings, MA Apicella, B Kobe, ...
Antioxidants & Redox Signaling 18 (7), 743-755, 2013
192013
WNT activates the AAK1 kinase to promote clathrin-mediated endocytosis of LRP6 and establish a negative feedback loop
MJ Agajanian, MP Walker, AD Axtman, RR Ruela-de-Sousa, DS Serafin, ...
Cell reports 26 (1), 79-93. e8, 2019
182019
Structures of Orf virus chemokine binding protein in complex with host chemokines reveal clues to broad binding specificity
RM Couñago, KM Knapp, Y Nakatani, SB Fleming, M Corbett, LM Wise, ...
Structure 23 (7), 1199-1213, 2015
172015
The distribution of different classes of nuclear localization signals (NLSs) in diverse organisms and the utilization of the minor NLS-binding site in plantnuclear import …
CW Chang, R Counago, S Williams, M Boden, B Kobe
Plant Signaling & Behavior 8 (10), e25976, 2013
152013
1, 2, 6-thiadiazinones as novel narrow spectrum calcium/calmodulin-dependent protein kinase kinase 2 (CaMKK2) Inhibitors
CRM Asquith, PH Godoi, RM Couñago, T Laitinen, JW Scott, ...
Molecules 23 (5), 1221, 2018
122018
In depth analysis of kinase cross screening data to identify chemical starting points for inhibition of the Nek family of kinases
CI Wells, NR Kapadia, RM Couñago, DH Drewry
MedChemComm 9 (1), 44-66, 2018
122018
Structural characterization of human Vaccinia-Related Kinases (VRK) bound to small-molecule inhibitors identifies different P-loop conformations
RM Couñago, CK Allerston, P Savitsky, H Azevedo, PH Godoi, CI Wells, ...
Scientific reports 7 (1), 1-12, 2017
92017
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Articles 1–20