| A randomized trial of protocol-based care for early septic shock ProCESS Investigators New England Journal of Medicine 370 (18), 1683-1693, 2014 | 2498 | 2014 |
| Lactate clearance vs central venous oxygen saturation as goals of early sepsis therapy: a randomized clinical trial AE Jones, NI Shapiro, S Trzeciak, RC Arnold, HA Claremont, JA Kline, ... Jama 303 (8), 739-746, 2010 | 1345 | 2010 |
| Discovery and validation of cell cycle arrest biomarkers in human acute kidney injury K Kashani, A Al-Khafaji, T Ardiles, A Artigas, SM Bagshaw, M Bell, ... Critical care 17 (1), 1-12, 2013 | 1050 | 2013 |
| Association between arterial hyperoxia following resuscitation from cardiac arrest and in-hospital mortality JH Kilgannon, AE Jones, NI Shapiro, MG Angelos, B Milcarek, K Hunter, ... Jama 303 (21), 2165-2171, 2010 | 910 | 2010 |
| Symptom duration and risk factors for delayed return to usual health among outpatients with COVID-19 in a multistate health care systems network—United States, March–June 2020 MW Tenforde, SS Kim, CJ Lindsell, EB Rose, NI Shapiro, DC Files, ... Morbidity and Mortality Weekly Report 69 (30), 993, 2020 | 855 | 2020 |
| Serum lactate as a predictor of mortality in emergency department patients with infection NI Shapiro, MD Howell, D Talmor, LA Nathanson, A Lisbon, RE Wolfe, ... Annals of emergency medicine 45 (5), 524-528, 2005 | 833 | 2005 |
| Multicenter study of early lactate clearance as a determinant of survival in patients with presumed sepsis RC Arnold, NI Shapiro, AE Jones, C Schorr, J Pope, E Casner, JE Parrillo, ... Shock 32 (1), 35-39, 2009 | 608 | 2009 |
| Mortality in Emergency Department Sepsis (MEDS) score: a prospectively derived and validated clinical prediction rule NI Shapiro, RE Wolfe, RB Moore, E Smith, E Burdick, DW Bates Critical care medicine 31 (3), 670-675, 2003 | 570 | 2003 |
| National estimates of severe sepsis in United States emergency departments HE Wang, NI Shapiro, DC Angus, DM Yealy Critical care medicine 35 (8), 1928-1936, 2007 | 499 | 2007 |
| Implementation and outcomes of the Multiple Urgent Sepsis Therapies (MUST) protocol NI Shapiro, MD Howell, D Talmor, D Lahey, L Ngo, J Buras, RE Wolfe, ... Critical care medicine 34 (4), 1025-1032, 2006 | 456 | 2006 |
| Early increases in microcirculatory perfusion during protocol-directed resuscitation are associated with reduced multi-organ failure at 24 h in patients with sepsis S Trzeciak, JV McCoy, R Phillip Dellinger, RC Arnold, M Rizzuto, ... Intensive care medicine 34 (12), 2210-2217, 2008 | 435 | 2008 |
| Occult hypoperfusion and mortality in patients with suspected infection MD Howell, M Donnino, P Clardy, D Talmor, NI Shapiro Intensive care medicine 33 (11), 1892-1899, 2007 | 422 | 2007 |
| Association between timing of antibiotic administration and mortality from septic shock in patients treated with a quantitative resuscitation protocol MA Puskarich, S Trzeciak, NI Shapiro, RC Arnold, JM Horton, JR Studnek, ... Critical care medicine 39 (9), 2066, 2011 | 410 | 2011 |
| Demonstration of high‐fidelity simulation team training for emergency medicine SD Small, RC Wuerz, R Simon, N Shapiro, A Conn, G Setnik Academic Emergency Medicine 6 (4), 312-323, 1999 | 384 | 1999 |
| Relationship between supranormal oxygen tension and outcome after resuscitation from cardiac arrest JH Kilgannon, AE Jones, JE Parrillo, RP Dellinger, B Milcarek, K Hunter, ... Circulation 123 (23), 2717-2722, 2011 | 349 | 2011 |
| Diagnosing appendicitis: evidence-based review of the diagnostic approach in 2014 DJ Shogilev, N Duus, SR Odom, NI Shapiro Western Journal of Emergency Medicine 15 (7), 859, 2014 | 339 | 2014 |
| Multicenter study of central venous oxygen saturation (ScvO2) as a predictor of mortality in patients with sepsis JV Pope, AE Jones, DF Gaieski, RC Arnold, S Trzeciak, NI Shapiro, ... Annals of emergency medicine 55 (1), 40-46. e1, 2010 | 326 | 2010 |
| The glycocalyx: a novel diagnostic and therapeutic target in sepsis R Uchimido, EP Schmidt, NI Shapiro Critical care 23 (1), 1-12, 2019 | 317 | 2019 |
| A prospective, multicenter derivation of a biomarker panel to assess risk of organ dysfunction, shock, and death in emergency department patients with suspected sepsis NI Shapiro, S Trzeciak, JE Hollander, R Birkhahn, R Otero, TM Osborn, ... Critical care medicine 37 (1), 96-104, 2009 | 310 | 2009 |
| Effect of hydroxychloroquine on clinical status at 14 days in hospitalized patients with COVID-19: a randomized clinical trial WH Self, MW Semler, LM Leither, JD Casey, DC Angus, RG Brower, ... Jama 324 (21), 2165-2176, 2020 | 305 | 2020 |
