| A programmable dual-RNA–guided DNA endonuclease in adaptive bacterial immunity M Jinek, K Chylinski, I Fonfara, M Hauer, JA Doudna, E Charpentier science 337 (6096), 816-821, 2012 | 10393 | 2012 |
| The new frontier of genome engineering with CRISPR-Cas9 JA Doudna, E Charpentier Science 346 (6213), 2014 | 3926 | 2014 |
| Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression LS Qi, MH Larson, LA Gilbert, JA Doudna, JS Weissman, AP Arkin, ... Cell 152 (5), 1173-1183, 2013 | 3330 | 2013 |
| CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes LA Gilbert, MH Larson, L Morsut, Z Liu, GA Brar, SE Torres, ... Cell 154 (2), 442-451, 2013 | 2491 | 2013 |
| RNA-programmed genome editing in human cells M Jinek, A East, A Cheng, S Lin, E Ma, J Doudna elife 2, e00471, 2013 | 1931 | 2013 |
| RNA-guided genetic silencing systems in bacteria and archaea B Wiedenheft, SH Sternberg, JA Doudna Nature 482 (7385), 331-338, 2012 | 1849 | 2012 |
| Crystal structure of a group I ribozyme domain: principles of RNA packing JH Cate, AR Gooding, E Podell, K Zhou, BL Golden, CE Kundrot, ... Science 273 (5282), 1678-1685, 1996 | 1532 | 1996 |
| DNA interrogation by the CRISPR RNA-guided endonuclease Cas9 SH Sternberg, S Redding, M Jinek, EC Greene, JA Doudna Nature 507 (7490), 62-67, 2014 | 1368 | 2014 |
| High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity V Pattanayak, S Lin, JP Guilinger, E Ma, JA Doudna, DR Liu Nature biotechnology 31 (9), 839-843, 2013 | 1284 | 2013 |
| Structural basis for double-stranded RNA processing by Dicer IJ MacRae, K Zhou, F Li, A Repic, AN Brooks, WZ Cande, PD Adams, ... Science 311 (5758), 195-198, 2006 | 1092 | 2006 |
| Structures of Cas9 endonucleases reveal RNA-mediated conformational activation M Jinek, F Jiang, DW Taylor, SH Sternberg, E Kaya, E Ma, C Anders, ... Science 343 (6176), 2014 | 902 | 2014 |
| The chemical repertoire of natural ribozymes JA Doudna, TR Cech Nature 418 (6894), 222-228, 2002 | 880 | 2002 |
| Crystal structure of a hepatitis delta virus ribozyme AR Ferré-D'Amaré, K Zhou, JA Doudna Nature 395 (6702), 567-574, 1998 | 864 | 1998 |
| A three-dimensional view of the molecular machinery of RNA interference M Jinek, JA Doudna nature 457 (7228), 405-412, 2009 | 845 | 2009 |
| Molecular mechanisms of RNA interference RC Wilson, JA Doudna Annual review of biophysics 42, 217-239, 2013 | 827 | 2013 |
| Enhanced homology-directed human genome engineering by controlled timing of CRISPR/Cas9 delivery S Lin, BT Staahl, RK Alla, JA Doudna elife 3, e04766, 2014 | 810 | 2014 |
| Method and apparatus for awarding and redeeming promotional points at an electronic game WR Adams, TJ Matthews US Patent 7,025,674, 2006 | 758 | 2006 |
| Biology and applications of CRISPR systems: harnessing nature’s toolbox for genome engineering AV Wright, JK Nuñez, JA Doudna Cell 164 (1-2), 29-44, 2016 | 741 | 2016 |
| Sequence-and structure-specific RNA processing by a CRISPR endonuclease RE Haurwitz, M Jinek, B Wiedenheft, K Zhou, JA Doudna Science 329 (5997), 1355-1358, 2010 | 735 | 2010 |
| A prudent path forward for genomic engineering and germline gene modification D Baltimore, P Berg, M Botchan, D Carroll, RA Charo, G Church, JE Corn, ... Science 348 (6230), 36-38, 2015 | 710 | 2015 |
