Takip et
Igor Shamovsky
Igor Shamovsky
Medicinal Chemistry, RIA iMed, AstraZeneca
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Başlık
Alıntı yapanlar
Alıntı yapanlar
Yıl
The structure of the ferromagnetic phase of carbon
AA Ovchinnikov, IL Shamovsky
Journal of Molecular Structure: THEOCHEM 251, 133-140, 1991
981991
Reciprocal modulation of TrkA and p75NTR affinity states is mediated by direct receptor interactions
GM Ross, IL Shamovsky, G Lawrance, M Solc, SM Dostaler, DF Weaver, ...
European Journal of Neuroscience 10 (3), 890-898, 1998
961998
Zinc alters conformation and inhibits biological activities of nerve growth factor and related neurotrophins
GM Ross, IL Shamovsky, G Lawrance, M Solc, SM Dostaler, SL Jimmo, ...
Nature medicine 3 (8), 872-878, 1997
931997
Explanation for main features of structure–genotoxicity relationships of aromatic amines by theoretical studies of their activation pathways in CYP1A2
I Shamovsky, L Ripa, L Borjesson, C Mee, B Nordén, P Hansen, ...
Journal of the American Chemical Society 133 (40), 16168-16185, 2011
752011
The interaction of neurotrophins with the p75NTR common neurotrophin receptor: a comprehensive molecular modeling study
IL Shamovsky, GM Ross, RJ Riopelle, DF WEAVER
Protein science 8 (11), 2223-2233, 1999
721999
Theoretical studies on the origin of β-sheet twisting
IL Shamovsky, GM Ross, RJ Riopelle
The Journal of Physical Chemistry B 104 (47), 11296-11307, 2000
672000
Methods of screening for factors that disrupt neurotrophin conformation and reduce neurotrophin biological activity
RJ Riopelle, GM Ross, MI Dory, DF Weaver, IL Shamovsky
US Patent 6,291,247, 2001
642001
Differential activity of the nerve growth factor (NGF) antagonist PD90780 [7-(benzolylamino)-4, 9-dihydro-4-methyl-9-oxo-pyrazolo [5, 1-b] quinazoline-2-carboxylic acid …
A Colquhoun, GM Lawrance, IL Shamovsky, RJ Riopelle, GM Ross
Journal of Pharmacology and Experimental Therapeutics 310 (2), 505-511, 2004
612004
Overcoming undesirable HERG potency of chemokine receptor antagonists using baseline lipophilicity relationships
I Shamovsky, S Connolly, L David, S Ivanova, B Nordén, B Springthorpe, ...
Journal of medicinal chemistry 51 (5), 1162-1178, 2008
582008
Zinc inhibits p75NTR-mediated apoptosis in chick neural retina
C Allington, IL Shamovsky, GM Ross, RJ Riopelle
Cell Death & Differentiation 8 (5), 451-456, 2001
492001
Increasing selectivity of CC chemokine receptor 8 antagonists by engineering nondesolvation related interactions with the intended and off-target binding sites
I Shamovsky, C de Graaf, L Alderin, M Bengtsson, H Bladh, L Börjesson, ...
Journal of medicinal chemistry 52 (23), 7706-7723, 2009
372009
Ab initio prediction of the structure and stabilities of the hypermagnesium oxide molecules: Mg2O, Mg3O, and Mg4O
AI Boldyrev, IL Shamovskii, PR Schleyer
Journal of the American Chemical Society 114 (16), 6469-6475, 1992
371992
Theoretical studies of chemical reactivity of metabolically activated forms of aromatic amines toward DNA
I Shamovsky, L Ripa, N Blomberg, LA Eriksson, P Hansen, C Mee, ...
Chemical Research in Toxicology 25 (10), 2236-2252, 2012
352012
The binding of zinc and copper ions to nerve growth factor is differentially affected by pH: implications for cerebral acidosis
GM Ross, IL Shamovsky, SB Woo, JI Post, PN Vrkljan, G Lawrance, ...
Journal of neurochemistry 78 (3), 515-523, 2001
342001
Novel Diazaspiroalkanes and Their Use for Treatment of Ccr8 Mediated Diseases
H Bladh, S Connolly, H Dyke, A Lisius, S Price, I Shamovsky, ...
US Patent App. 10/575,525, 2007
322007
Ab initio studies on the mechanism of tyrosine coupling
IL Shamovsky, RJ Riopelle, GM Ross
The Journal of Physical Chemistry A 105 (6), 1061-1070, 2001
322001
Method of inhibiting neurotrophin-receptor binding
GM Ross, IL Shamovsky, S Marone, DF Weaver, RJ Riopelle
US Patent 6,492,380, 2002
312002
Discovery and early clinical development of an inhibitor of 5-lipoxygenase activating protein (AZD5718) for treatment of coronary artery disease
D Pettersen, J Broddefalk, H Emtenäs, MA Hayes, M Lemurell, ...
Journal of Medicinal Chemistry 62 (9), 4312-4324, 2019
302019
Molecular modelling of neurotrophin-receptor binding
IL Shamovsky, GM Ross, RJ Riopelle, DF Weaver
US Patent 6,029,114, 2000
302000
Theoretical and biochemical studies on the selectivity of nerve growth factor for transition metal cations
IL Shamovsky, GM Ross, RJ Riopelle, DF Weaver
Journal of the American Chemical Society 121 (42), 9797-9806, 1999
241999
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