Steven G. Younkin
Steven G. Younkin
Professor of Neuroscience, Mayo Clinic
Verified email at
Cited by
Cited by
Correlative memory deficits, Aβ elevation, and amyloid plaques in transgenic mice
K Hsiao, P Chapman, S Nilsen, C Eckman, Y Harigaya, S Younkin, ...
Science 274 (5284), 99-103, 1996
Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familialá…
D Scheuner, C Eckman, M Jensen, X Song, M Citron, N Suzuki, TD Bird, ...
Nature medicine 2 (8), 864-870, 1996
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease
JC Lambert, CA Ibrahim-Verbaas, D Harold, AC Naj, R Sims, ...
Nature genetics 45 (12), 1452-1458, 2013
Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease
D Harold, R Abraham, P Hollingworth, R Sims, A Gerrish, ML Hamshere, ...
Nature genetics 41 (10), 1088-1093, 2009
TREM2 Variants in Alzheimer's Disease
R Guerreiro, A Wojtas, J Bras, M Carrasquillo, E Rogaeva, E Majounie, ...
New England Journal of Medicine 368 (2), 117-127, 2013
An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants
N Suzuki, TT Cheung, XD Cai, A Odaka, L Otvos, C Eckman, TE Golde, ...
Science 264 (5163), 1336-1340, 1994
Familial Alzheimer's disease–linked presenilin 1 variants elevate Aβ1–42/1–40 ratio in vitro and in vivo
DR Borchelt, G Thinakaran, CB Eckman, MK Lee, F Davenport, ...
Neuron 17 (5), 1005-1013, 1996
Increased amyloid-β42 (43) in brains of mice expressing mutant presenilin 1
K Duff, C Eckman, C Zehr, X Yu, CM Prada, J Perez-Tur, M Hutton, L Buee, ...
Nature 383 (6602), 710-713, 1996
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease
AC Naj, G Jun, GW Beecham, LS Wang, BN Vardarajan, J Buros, ...
Nature genetics 43 (5), 436-441, 2011
Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease
P Hollingworth, D Harold, R Sims, A Gerrish, JC Lambert, ...
Nature genetics 43 (5), 429-435, 2011
Mutant presenilins specifically elevate the levels of the 42 residue β-amyloid peptide in vivo: evidence for augmentation of a 42-specific γ secretase
JL Jankowsky, DJ Fadale, J Anderson, GM Xu, V Gonzales, NA Jenkins, ...
Human molecular genetics 13 (2), 159-170, 2004
The'Arctic'APP mutation (E693G) causes Alzheimer's disease by enhanced Aβ protofibril formation
C Nilsberth, A Westlind-Danielsson, CB Eckman, MM Condron, ...
Nature neuroscience 4 (9), 887-893, 2001
Release of excess amyloid beta protein from a mutant amyloid beta protein precursor
XD Cai, TE Golde, SG Younkin
Science 259 (5094), 514-516, 1993
The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease
E Rogaeva, Y Meng, JH Lee, Y Gu, T Kawarai, F Zou, T Katayama, ...
Nature genetics 39 (2), 168-177, 2007
Age-dependent changes in brain, CSF, and plasma amyloid β protein in the Tg2576 transgenic mouse model of Alzheimer's disease
T Kawarabayashi, LH Younkin, TC Saido, M Shoji, KH Ashe, SG Younkin
Journal of neuroscience 21 (2), 372-381, 2001
Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice
PF Chapman, GL White, MW Jones, D Cooper-Blacketer, VJ Marshall, ...
Nature neuroscience 2 (3), 271-276, 1999
Processing of the amyloid protein precursor to potentially amyloidogenic derivatives
TE Golde, S Estus, LH Younkin, DJ Selkoe, SG Younkin
Science 255 (5045), 728-730, 1992
The relationship between Aβ and memory in the Tg2576 mouse model of Alzheimer's disease
MA Westerman, D Cooper-Blacketer, A Mariash, L Kotilinek, ...
Journal of neuroscience 22 (5), 1858-1867, 2002
Amyloid β protein (Aβ) in Alzheimeri's disease brain: Biochemical and immunocytochemical analysis with antibodies specific for forms ending at Aβ40 or Aβ42 (43)
SA Gravina, L Ho, CB Eckman, KE Long, L Otvos Jr, LH Younkin, ...
Journal of Biological Chemistry 270 (13), 7013-7016, 1995
Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing
BW Kunkle, B Grenier-Boley, R Sims, JC Bis, V Damotte, AC Naj, ...
Nature genetics 51 (3), 414-430, 2019
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