Steven G. Younkin
Steven G. Younkin
Professor of Neuroscience, Mayo Clinic
Verified email at mayo.edu
Title
Cited by
Cited by
Year
Correlative memory deficits, Aβ elevation, and amyloid plaques in transgenic mice
K Hsiao, P Chapman, S Nilsen, C Eckman, Y Harigaya, S Younkin, ...
Science 274 (5284), 99-103, 1996
48421996
Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familialá…
D Scheuner, C Eckman, M Jensen, X Song, M Citron, N Suzuki, TD Bird, ...
Nature medicine 2 (8), 864-870, 1996
31311996
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease
JC Lambert, CA Ibrahim-Verbaas, D Harold, AC Naj, R Sims, ...
Nature genetics 45 (12), 1452-1458, 2013
29272013
Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease
D Harold, R Abraham, P Hollingworth, R Sims, A Gerrish, ML Hamshere, ...
Nature genetics 41 (10), 1088-1093, 2009
27032009
TREM2 Variants in Alzheimer's Disease
R Guerreiro, A Wojtas, J Bras, M Carrasquillo, E Rogaeva, E Majounie, ...
New England Journal of Medicine 368 (2), 117-127, 2013
20112013
An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants
N Suzuki, TT Cheung, XD Cai, A Odaka, L Otvos, C Eckman, TE Golde, ...
Science 264 (5163), 1336-1340, 1994
19231994
Familial Alzheimer's disease–linked presenilin 1 variants elevate Aβ1–42/1–40 ratio in vitro and in vivo
DR Borchelt, G Thinakaran, CB Eckman, MK Lee, F Davenport, ...
Neuron 17 (5), 1005-1013, 1996
18841996
Increased amyloid-β42 (43) in brains of mice expressing mutant presenilin 1
K Duff, C Eckman, C Zehr, X Yu, CM Prada, J Perez-Tur, M Hutton, L Buee, ...
Nature 383 (6602), 710-713, 1996
18761996
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease
AC Naj, G Jun, GW Beecham, LS Wang, BN Vardarajan, J Buros, ...
Nature genetics 43 (5), 436-441, 2011
16782011
Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease
P Hollingworth, D Harold, R Sims, A Gerrish, JC Lambert, ...
Nature genetics 43 (5), 429-435, 2011
16772011
Mutant presenilins specifically elevate the levels of the 42 residue β-amyloid peptide in vivo: evidence for augmentation of a 42-specific γ secretase
JL Jankowsky, DJ Fadale, J Anderson, GM Xu, V Gonzales, NA Jenkins, ...
Human molecular genetics 13 (2), 159-170, 2004
13082004
The'Arctic'APP mutation (E693G) causes Alzheimer's disease by enhanced Aβ protofibril formation
C Nilsberth, A Westlind-Danielsson, CB Eckman, MM Condron, ...
Nature neuroscience 4 (9), 887-893, 2001
12592001
Release of excess amyloid beta protein from a mutant amyloid beta protein precursor
XD Cai, TE Golde, SG Younkin
Science 259 (5094), 514-516, 1993
12381993
The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease
E Rogaeva, Y Meng, JH Lee, Y Gu, T Kawarai, F Zou, T Katayama, ...
Nature genetics 39 (2), 168-177, 2007
11852007
Age-dependent changes in brain, CSF, and plasma amyloid β protein in the Tg2576 transgenic mouse model of Alzheimer's disease
T Kawarabayashi, LH Younkin, TC Saido, M Shoji, KH Ashe, SG Younkin
Journal of neuroscience 21 (2), 372-381, 2001
11582001
Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice
PF Chapman, GL White, MW Jones, D Cooper-Blacketer, VJ Marshall, ...
Nature neuroscience 2 (3), 271-276, 1999
10661999
Processing of the amyloid protein precursor to potentially amyloidogenic derivatives
TE Golde, S Estus, LH Younkin, DJ Selkoe, SG Younkin
Science 255 (5045), 728-730, 1992
8981992
The relationship between Aβ and memory in the Tg2576 mouse model of Alzheimer's disease
MA Westerman, D Cooper-Blacketer, A Mariash, L Kotilinek, ...
Journal of neuroscience 22 (5), 1858-1867, 2002
8112002
Amyloid β protein (Aβ) in Alzheimeri's disease brain: Biochemical and immunocytochemical analysis with antibodies specific for forms ending at Aβ40 or Aβ42 (43)
SA Gravina, L Ho, CB Eckman, KE Long, L Otvos Jr, LH Younkin, ...
Journal of Biological Chemistry 270 (13), 7013-7016, 1995
7321995
Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing
BW Kunkle, B Grenier-Boley, R Sims, JC Bis, V Damotte, AC Naj, ...
Nature genetics 51 (3), 414-430, 2019
6852019
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