The Ndc80 kinetochore complex forms load-bearing attachments to dynamic microtubule tips via biased diffusion AF Powers, AD Franck, DR Gestaut, J Cooper, B Gracyzk, RR Wei, ... Cell 136 (5), 865-875, 2009 | 324 | 2009 |
Cooperation of the Dam1 and Ndc80 kinetochore complexes enhances microtubule coupling and is regulated by aurora B JF Tien, NT Umbreit, DR Gestaut, AD Franck, J Cooper, L Wordeman, ... Journal of Cell Biology 189 (4), 713-723, 2010 | 245 | 2010 |
The Dam1 kinetochore complex harnesses microtubule dynamics to produce force and movement CL Asbury, DR Gestaut, AF Powers, AD Franck, TN Davis Proceedings of the National Academy of Sciences 103 (26), 9873-9878, 2006 | 228 | 2006 |
Tension applied through the Dam1 complex promotes microtubule elongation providing a direct mechanism for length control in mitosis AD Franck, AF Powers, DR Gestaut, T Gonen, TN Davis, CL Asbury Nature cell biology 9 (7), 832-837, 2007 | 191 | 2007 |
Phosphoregulation and depolymerization-driven movement of the Dam1 complex do not require ring formation DR Gestaut, B Graczyk, J Cooper, PO Widlund, A Zelter, L Wordeman, ... Nature cell biology 10 (4), 407-414, 2008 | 183 | 2008 |
The organization of the core proteins of the yeast spindle pole body EGD Muller, BE Snydsman, I Novik, DW Hailey, DR Gestaut, CA Niemann, ... Molecular Biology of the Cell 16 (7), 3341-3352, 2005 | 155 | 2005 |
The organization of the core proteins of the yeast spindle pole body EGD Muller, BE Snydsman, I Novik, DW Hailey, DR Gestaut, CA Niemann, ... Molecular Biology of the Cell 16 (7), 3341-3352, 2005 | 155 | 2005 |
The Ndc80 kinetochore complex directly modulates microtubule dynamics NT Umbreit, DR Gestaut, JF Tien, BS Vollmar, T Gonen, CL Asbury, ... Proceedings of the National Academy of Sciences 109 (40), 16113-16118, 2012 | 142 | 2012 |
The chaperonin TRiC/CCT associates with prefoldin through a conserved electrostatic interface essential for cellular proteostasis D Gestaut, SH Roh, B Ma, G Pintilie, LA Joachimiak, A Leitner, ... Cell 177 (3), 751-765. e15, 2019 | 115 | 2019 |
The ATP-powered gymnastics of TRiC/CCT: an asymmetric protein folding machine with a symmetric origin story D Gestaut, A Limatola, L Joachimiak, J Frydman Current opinion in structural biology 55, 50-58, 2019 | 72 | 2019 |
The TRiC chaperonin controls reovirus replication through outer-capsid folding JJ Knowlton, I Fernandez de Castro, AW Ashbrook, DR Gestaut, ... Nature microbiology 3 (4), 481-493, 2018 | 57 | 2018 |
Regulation of outer kinetochore Ndc80 complex-based microtubule attachments by the central kinetochore Mis12/MIND complex EM Kudalkar, EA Scarborough, NT Umbreit, A Zelter, DR Gestaut, M Riffle, ... Proceedings of the National Academy of Sciences 112 (41), E5583-E5589, 2015 | 56 | 2015 |
Direct physical study of kinetochore–microtubule interactions by reconstitution and interrogation with an optical force clamp AD Franck, AF Powers, DR Gestaut, TN Davis, CL Asbury Methods 51 (2), 242-250, 2010 | 54 | 2010 |
Native capillary isoelectric focusing for the separation of protein complex isoforms and subcomplexes BR Fonslow, SA Kang, DR Gestaut, B Graczyk, TN Davis, DM Sabatini, ... Analytical chemistry 82 (15), 6643-6651, 2010 | 47 | 2010 |
Structural and functional dissection of reovirus capsid folding and assembly by the prefoldin-TRiC/CCT chaperone network JJ Knowlton, D Gestaut, B Ma, G Taylor, AB Seven, A Leitner, GJ Wilson, ... Proceedings of the National Academy of Sciences 118 (11), e2018127118, 2021 | 33 | 2021 |
Structural visualization of the tubulin folding pathway directed by human chaperonin TRiC/CCT D Gestaut, Y Zhao, J Park, B Ma, A Leitner, M Collier, G Pintilie, SH Roh, ... Cell 185 (25), 4770-4787. e20, 2022 | 29 | 2022 |
Reconstitution and functional analysis of kinetochore subcomplexes DR Gestaut, J Cooper, CL Asbury, TN Davis, L Wordeman Methods in cell biology 95, 641-656, 2010 | 26 | 2010 |
Nuclear and cytoplasmic spatial protein quality control is coordinated by nuclear–vacuolar junctions and perinuclear ESCRT EM Sontag, F Morales-Polanco, JH Chen, G McDermott, PT Dolan, ... Nature Cell Biology 25 (5), 699-713, 2023 | 16 | 2023 |
Ribotoxic collisions on CAG expansions disrupt proteostasis and stress responses in Huntington’s Disease R Aviner, TT Lee, VB Masto, D Gestaut, KH Li, R Andino, J Frydman BiorXiv, 2022.05. 04.490528, 2022 | 7 | 2022 |
Fine-Tuned Protein Production in Methanosarcina acetivorans C2A AA Karim, DR Gestaut, M Fincker, JC Ruth, EC Holmes, W Sheu, ... ACS Synthetic Biology 7 (8), 1874-1885, 2018 | 4 | 2018 |