Marcel van der Brug
Marcel van der Brug
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Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease
C Paisán-Ruı́z, S Jain, EW Evans, WP Gilks, J Simón, M Van Der Brug, ...
Neuron 44 (4), 595-600, 2004
Genome-wide association study reveals genetic risk underlying Parkinson's disease
J Simon-Sanchez, C Schulte, JM Bras, M Sharma, JR Gibbs, D Berg, ...
Nature genetics 41 (12), 1308-1312, 2009
The Parkinson progression marker initiative (PPMI)
K Marek, D Jennings, S Lasch, A Siderowf, C Tanner, T Simuni, C Coffey, ...
Progress in neurobiology 95 (4), 629-635, 2011
Abundant quantitative trait loci exist for DNA methylation and gene expression in human brain
JR Gibbs, MP Van Der Brug, DG Hernandez, BJ Traynor, MA Nalls, SL Lai, ...
PLoS genetics 6 (5), e1000952, 2010
Kinase activity is required for the toxic effects of mutant LRRK2/dardarin
E Greggio, S Jain, A Kingsbury, R Bandopadhyay, P Lewis, A Kaganovich, ...
Neurobiology of disease 23 (2), 329-341, 2006
Common genetic variants influence human subcortical brain structures
DP Hibar, JL Stein, ME Renteria, A Arias-Vasquez, S Desrivières, ...
Nature 520 (7546), 224-229, 2015
A meta-analysis of genome-wide association studies identifies 17 new Parkinson's disease risk loci
D Chang, MA Nalls, IB Hallgrímsdóttir, J Hunkapiller, M Van Der Brug, ...
Nature genetics 49 (10), 1511-1516, 2017
Genetic variability in the regulation of gene expression in ten regions of the human brain
A Ramasamy, D Trabzuni, S Guelfi, V Varghese, C Smith, R Walker, T De, ...
Nature neuroscience 17 (10), 1418-1428, 2014
Inhibition of natural antisense transcripts in vivo results in gene-specific transcriptional upregulation
F Modarresi, MA Faghihi, MA Lopez-Toledano, RP Fatemi, M Magistri, ...
Nature biotechnology 30 (5), 453-459, 2012
Evidence for natural antisense transcript-mediated inhibition of microRNA function
MA Faghihi, M Zhang, J Huang, F Modarresi, MP Van der Brug, MA Nalls, ...
Genome biology 11 (5), 1-13, 2010
Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy
GU Höglinger, NM Melhem, DW Dickson, PMA Sleiman, LS Wang, L Klei, ...
Nature genetics 43 (7), 699-705, 2011
DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy
KJ Thomas, MK McCoy, J Blackinton, A Beilina, M van der Brug, ...
Human molecular genetics 20 (1), 40-50, 2011
Mutations in PTEN-induced putative kinase 1 associated with recessive parkinsonism have differential effects on protein stability
A Beilina, M Van Der Brug, R Ahmad, S Kesavapany, DW Miller, ...
Proceedings of the National Academy of Sciences 102 (16), 5703-5708, 2005
Distinct DNA methylation changes highly correlated with chronological age in the human brain
DG Hernandez, MA Nalls, JR Gibbs, S Arepalli, M van der Brug, S Chong, ...
Human molecular genetics 20 (6), 1164-1172, 2011
The transcriptional landscape of age in human peripheral blood
MJ Peters, R Joehanes, LC Pilling, C Schurmann, KN Conneely, J Powell, ...
Nature communications 6 (1), 1-14, 2015
Genome-wide association study of obsessive-compulsive disorder
SE Stewart, D Yu, JM Scharf, BM Neale, JA Fagerness, CA Mathews, ...
Molecular psychiatry 18 (7), 788-798, 2013
Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease
A Beilina, IN Rudenko, A Kaganovich, L Civiero, H Chau, SK Kalia, ...
Proceedings of the National Academy of Sciences 111 (7), 2626-2631, 2014
Ser1292 autophosphorylation is an indicator of LRRK2 kinase activity and contributes to the cellular effects of PD mutations
Z Sheng, S Zhang, D Bustos, T Kleinheinz, CE Le Pichon, SL Dominguez, ...
Science translational medicine 4 (164), 164ra161-164ra161, 2012
Diverse brain myeloid expression profiles reveal distinct microglial activation states and aspects of Alzheimer’s disease not evident in mouse models
BA Friedman, K Srinivasan, G Ayalon, WJ Meilandt, H Lin, MA Huntley, ...
Cell reports 22 (3), 832-847, 2018
Platelets activated during myocardial infarction release functional miRNA, which can be taken up by endothelial cells and regulate ICAM1 expression
O Gidlöf, M Van Der Brug, J Öhman, P Gilje, B Olde, C Wahlestedt, ...
Blood, The Journal of the American Society of Hematology 121 (19), 3908-3917, 2013
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