Neeraj Dhar
Neeraj Dhar
Principal Scientist, Vaccine and Infectious Disease Organization, University of Saskatchewan, Canada
Verified email at - Homepage
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Benzothiazinones kill Mycobacterium tuberculosis by blocking arabinan synthesis
V Makarov, G Manina, K Mikusova, U Möllmann, O Ryabova, ...
Science 324 (5928), 801-804, 2009
Dynamic persistence of antibiotic-stressed mycobacteria
Y Wakamoto, N Dhar, R Chait, K Schneider, F Signorino-Gelo, S Leibler, ...
Science 339 (6115), 91-95, 2013
Microbial phenotypic heterogeneity and antibiotic tolerance
N Dhar, JD McKinney
Current opinion in microbiology 10 (1), 30-38, 2007
Stress and host immunity amplify Mycobacterium tuberculosis phenotypic heterogeneity and induce nongrowing metabolically active forms
G Manina, N Dhar, JD McKinney
Cell host & microbe 17 (1), 32-46, 2015
Delayed bactericidal response of Mycobacterium tuberculosis to bedaquiline involves remodelling of bacterial metabolism
A Koul, L Vranckx, N Dhar, HWH Göhlmann, E Özdemir, JM Neefs, ...
Nature communications 5 (1), 3369, 2014
Structural basis for benzothiazinone-mediated killing of Mycobacterium tuberculosis
J Neres, F Pojer, E Molteni, LR Chiarelli, N Dhar, S Boy-Röttger, S Buroni, ...
Science translational medicine 4 (150), 150ra121-150ra121, 2012
Disruption of mptpB impairs the ability of Mycobacterium tuberculosis to survive in guinea pigs
R Singh, V Rao, H Shakila, R Gupta, A Khera, N Dhar, A Singh, A Koul, ...
Molecular microbiology 50 (3), 751-762, 2003
Single-cell dynamics of the chromosome replication and cell division cycles in mycobacteria
I Santi, N Dhar, D Bousbaine, Y Wakamoto, JD McKinney
Nature communications 4 (1), 2470, 2013
Simple Model for Testing Drugs against Nonreplicating Mycobacterium tuberculosis
C Sala, N Dhar, RC Hartkoorn, M Zhang, YH Ha, P Schneider, ST Cole
Antimicrobial agents and chemotherapy 54 (10), 4150-4158, 2010
Mycobacterium tuberculosis persistence mutants identified by screening in isoniazid-treated mice
N Dhar, JD McKinney
Proceedings of the National Academy of Sciences 107 (27), 12275-12280, 2010
Nanoparticle conjugation and pulmonary delivery enhance the protective efficacy of Ag85B and CpG against tuberculosis
M Ballester, C Nembrini, N Dhar, A De Titta, C De Piano, M Pasquier, ...
Vaccine 29 (40), 6959-6966, 2011
2-Carboxyquinoxalines Kill Mycobacterium tuberculosis through Noncovalent Inhibition of DprE1
J Neres, RC Hartkoorn, LR Chiarelli, R Gadupudi, MR Pasca, G Mori, ...
ACS chemical biology 10 (3), 705-714, 2015
Rapid cytolysis of Mycobacterium tuberculosis by faropenem, an orally bioavailable β-lactam antibiotic
N Dhar, V Dubée, L Ballell, G Cuinet, JE Hugonnet, F Signorino-Gelo, ...
Antimicrobial agents and chemotherapy 59 (2), 1308-1319, 2015
Streptomycin-starved Mycobacterium tuberculosis 18b, a drug discovery tool for latent tuberculosis
M Zhang, C Sala, RC Hartkoorn, N Dhar, A Mendoza-Losana, ST Cole
Antimicrobial agents and chemotherapy 56 (11), 5782-5789, 2012
EspD is critical for the virulence-mediating ESX-1 secretion system in Mycobacterium tuberculosis
JM Chen, S Boy-Röttger, N Dhar, N Sweeney, RS Buxton, F Pojer, ...
Journal of bacteriology 194 (4), 884-893, 2012
Stressed mycobacteria use the chaperone ClpB to sequester irreversibly oxidized proteins asymmetrically within and between cells
J Vaubourgeix, G Lin, N Dhar, N Chenouard, X Jiang, H Botella, T Lupoli, ...
Cell host & microbe 17 (2), 178-190, 2015
A lung-on-chip model of early Mycobacterium tuberculosis infection reveals an essential role for alveolar epithelial cells in controlling bacterial growth
VV Thacker, N Dhar, K Sharma, R Barrile, K Karalis, JD McKinney
Elife 9, e59961, 2020
4-aminoquinolone piperidine amides: noncovalent inhibitors of DprE1 with long residence time and potent antimycobacterial activity
M Naik, V Humnabadkar, SJ Tantry, M Panda, A Narayan, S Guptha, ...
Journal of medicinal chemistry 57 (12), 5419-5434, 2014
Assessing the essentiality of the decaprenyl‐phospho‐d‐arabinofuranose pathway in Mycobacterium tuberculosis using conditional mutants
GS Kolly, F Boldrin, C Sala, N Dhar, RC Hartkoorn, M Ventura, A Serafini, ...
Molecular microbiology 92 (1), 194-211, 2014
The inosine monophosphate dehydrogenase, GuaB2, is a vulnerable new bactericidal drug target for tuberculosis
V Singh, S Donini, A Pacitto, C Sala, RC Hartkoorn, N Dhar, G Keri, ...
ACS infectious diseases 3 (1), 5-17, 2017
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