Dimethyl sulfoxide reduces the stability but enhances catalytic activity of the main SARS‐CoV‐2 protease 3CLpro JC Ferreira, S Fadl, M Ilter, H Pekel, R Rezgui, O Sensoy, WM Rabeh The FASEB Journal 35 (8), 2021 | 14 | 2021 |
Design and synthesis of novel cylopentapyrazoles bearing 1, 2, 3-thiadiazole moiety as potent antifungal agents B Giray, AE Karadağ, ÖŞ İpek, H Pekel, M Güzel, HB Küçük Bioorganic Chemistry 95, 103509, 2020 | 13 | 2020 |
Inhibition of SARS-CoV-2 main protease: a repurposing study that targets the dimer interface of the protein H Pekel, M Ilter, O Sensoy Journal of Biomolecular Structure and Dynamics 40 (15), 7167-7182, 2022 | 9 | 2022 |
Synthesis, structural investigations, DNA/BSA interactions, molecular docking studies, and anticancer activity of a new 1, 4-disubstituted 1, 2, 3-triazole derivative T Göktürk, E Sakallı Çetin, T Hökelek, H Pekel, O Şensoy, EN Aksu, ... ACS omega 8 (35), 31839-31856, 2023 | 6 | 2023 |
Mechanistic insight into impact of phosphorylation on the enzymatic steps of farnesyltransferase H Pekel, M Guzel, O Sensoy Protein Science 31 (10), e4414, 2022 | 1 | 2022 |
Small therapeutic molecules capable of inhibiting the catalytic activity of the main protease enzyme of sars-cov-2 Ö Sensoy, M Ilter, H Pekel US Patent App. 18/255,396, 2024 | | 2024 |
Mechanistic insight into impact of phosphorylation on dynamics of farnesyltransferase: targeting the protein under hyperinsulinemia H Pekel, M Guzel, O Sensoy Biophysical Journal 121 (3), 345a-346a, 2022 | | 2022 |
Hiperinsülinemi etkisiyle posttranslasyonel modifikasyona uğrayan enzimlerin dinamiğinin incelenmesi ve inhibitör moleküllerin araştırılarak in vitro ortamda test edilmesi H Pekel İstanbul Medipol Üniversitesi, Sağlık Bilimleri Enstitüsü, 2022 | | 2022 |