Post-translational modifications of Hsp90 and translating the chaperone code SJ Backe, RA Sager, MR Woodford, AM Makedon, M Mollapour Journal of Biological Chemistry 295 (32), 11099-11117, 2020 | 132 | 2020 |
Asymmetric Hsp90 N domain SUMOylation recruits Aha1 and ATP-competitive inhibitors M Mollapour, D Bourboulia, K Beebe, MR Woodford, S Polier, A Hoang, ... Molecular cell 53 (2), 317-329, 2014 | 130 | 2014 |
Tumor suppressor Tsc1 is a new Hsp90 co‐chaperone that facilitates folding of kinase and non‐kinase clients MR Woodford, RA Sager, E Marris, DM Dunn, AR Blanden, RL Murphy, ... The EMBO journal 36 (24), 3650-3665, 2017 | 79 | 2017 |
Structural and functional basis of protein phosphatase 5 substrate specificity J Oberoi, DM Dunn, MR Woodford, L Mariotti, J Schulman, D Bourboulia, ... Proceedings of the National Academy of Sciences 113 (32), 9009-9014, 2016 | 74 | 2016 |
Mps1 mediated phosphorylation of Hsp90 confers renal cell carcinoma sensitivity and selectivity to Hsp90 inhibitors MR Woodford, AW Truman, DM Dunn, SM Jensen, R Cotran, R Bullard, ... Cell reports 14 (4), 872-884, 2016 | 66 | 2016 |
c-Abl mediated tyrosine phosphorylation of Aha1 activates its co-chaperone function in cancer cells DM Dunn, MR Woodford, AW Truman, SM Jensen, J Schulman, T Caza, ... Cell reports 12 (6), 1006-1018, 2015 | 63 | 2015 |
The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding MR Woodford, DM Dunn, AR Blanden, D Capriotti, D Loiselle, ... Nature communications 7 (1), 12037, 2016 | 62 | 2016 |
Co-chaperones TIMP2 and AHA1 competitively regulate extracellular HSP90: client MMP2 activity and matrix proteolysis AJ Baker-Williams, F Hashmi, MA Budzyński, MR Woodford, S Gleicher, ... Cell reports 28 (7), 1894-1906. e6, 2019 | 56 | 2019 |
Chemical perturbation of oncogenic protein folding: from the prediction of locally unstable structures to the design of disruptors of Hsp90–client interactions A Paladino, MR Woodford, SJ Backe, RA Sager, P Kancherla, ... Chemistry–A European Journal 26 (43), 9459-9465, 2020 | 49 | 2020 |
Impact of posttranslational modifications on the anticancer activity of Hsp90 inhibitors MR Woodford, D Dunn, JB Miller, S Jamal, L Neckers, M Mollapour Advances in cancer research 129, 31-50, 2016 | 44 | 2016 |
Phosphorylation and ubiquitination regulate protein phosphatase 5 activity and its prosurvival role in kidney cancer N Dushukyan, DM Dunn, RA Sager, MR Woodford, DR Loiselle, ... Cell reports 21 (7), 1883-1895, 2017 | 42 | 2017 |
Post-translational regulation of FNIP1 creates a rheostat for the molecular chaperone Hsp90 RA Sager, MR Woodford, SJ Backe, AM Makedon, AJ Baker-Williams, ... Cell reports 26 (5), 1344-1356. e5, 2019 | 38 | 2019 |
Structural and functional regulation of lactate dehydrogenase-A in cancer MR Woodford, VZ Chen, SJ Backe, G Bratslavsky, M Mollapour Future Medicinal Chemistry 12 (5), 439-455, 2019 | 36 | 2019 |
Extracellular phosphorylation of TIMP-2 by secreted c-Src tyrosine kinase controls MMP-2 activity J Sánchez-Pozo, AJ Baker-Williams, MR Woodford, R Bullard, B Wei, ... Iscience 1, 87-96, 2018 | 28 | 2018 |
Structure and function of the co-chaperone protein phosphatase 5 in cancer RA Sager, N Dushukyan, M Woodford, M Mollapour Cell Stress and Chaperones 25 (3), 383-394, 2020 | 25 | 2020 |
The tumor suppressor folliculin inhibits lactate dehydrogenase A and regulates the Warburg effect MR Woodford, AJ Baker-Williams, RA Sager, SJ Backe, AR Blanden, ... Nature structural & molecular biology 28 (8), 662-670, 2021 | 24 | 2021 |
TRAP1 chaperones the metabolic switch in cancer LA Wengert, SJ Backe, D Bourboulia, M Mollapour, MR Woodford Biomolecules 12 (6), 786, 2022 | 18 | 2022 |
Design of disruptors of the Hsp90–Cdc37 Interface I D’Annessa, N Hurwitz, V Pirota, GL Beretta, S Tinelli, M Woodford, ... Molecules 25 (2), 360, 2020 | 18 | 2020 |
Mutation of the co-chaperone Tsc1 in bladder cancer diminishes Hsp90 acetylation and reduces drug sensitivity and selectivity MR Woodford, M Hughes, RA Sager, SJ Backe, AJ Baker-Williams, ... Oncotarget 10 (56), 5824, 2019 | 18 | 2019 |
Detecting posttranslational modifications of Hsp90 RA Sager, MR Woodford, L Neckers, M Mollapour Chaperones: Methods and Protocols, 209-219, 2018 | 18 | 2018 |