Richard J Lewis
Richard J Lewis
Medicinal Chemistry, RIA IMED, AstraZeneca
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Başlık
Alıntı yapanlar
Alıntı yapanlar
Yıl
From ATP to AZD6140: the discovery of an orally active reversible P2Y12 receptor antagonist for the prevention of thrombosis
B Springthorpe, A Bailey, P Barton, TN Birkinshaw, RV Bonnert, ...
Bioorganic & medicinal chemistry letters 17 (21), 6013-6018, 2007
2492007
Structural and conformational determinants of macrocycle cell permeability
B Over, P Matsson, C Tyrchan, P Artursson, BC Doak, MA Foley, ...
Nature chemical biology 12 (12), 1065-1074, 2016
1082016
Utilization of SABRE-derived hyperpolarization to detect low-concentration analytes via 1D and 2D NMR methods
LS Lloyd, RW Adams, M Bernstein, S Coombes, SB Duckett, GGR Green, ...
Journal of the American Chemical Society 134 (31), 12904-12907, 2012
1002012
Hyperpolarisation through reversible interactions with para hydrogen
LS Lloyd, A Asghar, MJ Burns, A Charlton, S Coombes, MJ Cowley, ...
Catalysis Science & Technology 4 (10), 3544-3554, 2014
792014
Optimization of monocarboxylate transporter 1 blockers through analysis and modulation of atropisomer interconversion properties
SD Guile, JR Bantick, ME Cooper, DK Donald, C Eyssade, AH Ingall, ...
Journal of medicinal chemistry 50 (2), 254-263, 2007
622007
A comparison of capillary‐scale LC–NMR with alternative techniques: spectroscopic and practical considerations
RJ Lewis, MA Bernstein, SJ Duncan, CJ Sleigh
Magnetic Resonance in Chemistry 43 (9), 783-789, 2005
542005
Structure-guided discovery of potent and selective inhibitors of ERK1/2 from a modestly active and promiscuous chemical start point
RA Ward, P Bethel, C Cook, E Davies, JE Debreczeni, G Fairley, L Feron, ...
Journal of medicinal chemistry 60 (8), 3438-3450, 2017
362017
Selective excitation of overlapping multiplets; the application of doubly selective and chemical shift filter experiments to complex NMR spectra
SJ Duncan, R Lewis, MA Bernstein, P Sandor
Magnetic Resonance in Chemistry 45 (4), 283-288, 2007
292007
Structure–activity studies on amides inhibiting photosystem II
RJ Lewis, P Camilleri, AJ Kirby, CA Marby, AA Slawin, DJ Williams
Journal of the Chemical Society, Perkin Transactions 2, 1625-1630, 1991
261991
The importance of ion-pairing in peptide purification by reversed-phase liquid chromatography
D Åsberg, AL Weinmann, T Leek, RJ Lewis, M Klarqvist, M Leśko, ...
Journal of Chromatography A 1496, 80-91, 2017
182017
Synthesis and Evaluation of the First Fluorescent Antagonists of the Human P2Y2 Receptor Based on AR-C118925
S Conroy, ND Kindon, J Glenn, LA Stoddart, RJ Lewis, SJ Hill, B Kellam, ...
Journal of medicinal chemistry 61 (7), 3089-3113, 2018
152018
Saccharin Aza Bioisosteres Synthesis and Preclinical Property Comparisons
Y Chen, CJ Aurell, A Pettersen, RJ Lewis, MA Hayes, M Lepistö, ...
ACS medicinal chemistry letters 8 (6), 672-677, 2017
152017
Which hydroxy? Evidence for species differences in the regioselectivity of glucuronidation in rat, dog, and human in vitro systems and dog in vivo
IJ Martin, RJ Lewis, MA Bernstein, IG Beattie, CA Martin, RJ Riley, ...
Drug metabolism and disposition 34 (9), 1502-1507, 2006
142006
Discovery of a potent and selective oral inhibitor of ERK1/2 (AZD0364) that is efficacious in both monotherapy and combination therapy in models of nonsmall cell lung cancer …
RA Ward, MJ Anderton, P Bethel, J Breed, C Cook, EJ Davies, A Dobson, ...
Journal of medicinal chemistry 62 (24), 11004-11018, 2019
132019
NMR identification of an S-linked glucuronide of a triazole thione formed in vitro
IJ Martin, RJ Lewis, RV Bonnert, P Cage, GC Moody
Drug metabolism and disposition 31 (6), 694-696, 2003
132003
In silico prediction of acyl glucuronide reactivity
T Potter, R Lewis, T Luker, R Bonnert, MA Bernstein, TN Birkinshaw, ...
Journal of computer-aided molecular design 25 (11), 997-1005, 2011
122011
N-(3, 4-Dichlorophenyl) cyclopropanecarboxamide and N-(3, 4-dichlorophenyl) acetamide
PG Jones, AJ Kirby, RJ Lewis
Acta Crystallographica Section C: Crystal Structure Communications 46 (1), 78-81, 1990
121990
Impact of excited-state antiaromaticity relief in a fundamental benzene photoreaction leading to substituted bicyclo [3.1. 0] hexenes
T Slanina, R Ayub, J Toldo, J Sundell, W Rabten, M Nicaso, I Alabugin, ...
Journal of the American Chemical Society 142 (25), 10942-10954, 2020
112020
Preliminary investigations into the use of supercritical fluid extraction to extract a novel corticosteroid (tipredane INN) from rodent diet
MR Euerby, RJ Lewis, SC Nichols
Analytical proceedings 28 (9), 287-289, 1991
111991
Design of novel and potent cPLA2α inhibitors containing an α-methyl-2-ketothiazole as a metabolically stable serine trap
A Mete, G Andrews, M Bernstein, S Connolly, P Hartopp, CG Jackson, ...
Bioorganic & medicinal chemistry letters 21 (10), 3128-3133, 2011
102011
Sistem, işlemi şu anda gerçekleştiremiyor. Daha sonra yeniden deneyin.
Makaleler 1–20