Marketa Zvelebil
Marketa Zvelebil
Assistant Professor in Cancer Informatics, ICR
Verified email at
Cited by
Cited by
Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction.
MP Wymann, G Bulgarelli-Leva, MJ Zvelebil, L Pirola, B Vanhaesebroeck, ...
Molecular and cellular biology 16 (4), 1722-1733, 1996
The Identification of 2-(1H-Indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a Potent, Selective …
AJ Folkes, K Ahmadi, WK Alderton, S Alix, SJ Baker, G Box, ...
Journal of medicinal chemistry 51 (18), 5522-5532, 2008
Distinct specificity in the recognition of phosphoinositides by the pleckstrin homology domains of dynamin and Bruton's tyrosine kinase.
K Salim, MJ Bottomley, E Querfurth, MJ Zvelebil, I Gout, R Scaife, ...
The EMBO journal 15 (22), 6241-6250, 1996
Prediction of protein secondary structure and active sites using the alignment of homologous sequences
MJ Zvelebil, GJ Barton, WR Taylor, MJE Sternberg
Journal of molecular biology 195 (4), 957-961, 1987
Phosphoinositide 3-kinase signalling–which way to target?
MP Wymann, M Zvelebil, M Laffargue
Trends in pharmacological sciences 24 (7), 366-376, 2003
P110δ, a novel phosphoinositide 3-kinase in leukocytes
B Vanhaesebroeck, MJ Welham, K Kotani, R Stein, PH Warne, ...
Proceedings of the National Academy of Sciences 94 (9), 4330-4335, 1997
Exploring the specificity of the PI3K family inhibitor LY294002
SI Gharbi, MJ Zvelebil, SJ Shuttleworth, T Hancox, N Saghir, JF Timms, ...
Biochemical Journal 404 (1), 15-21, 2007
A human phosphatidylinositol 3‐kinase complex related to the yeast Vps34p‐Vps15p protein sorting system.
S Volinia, R Dhand, B Vanhaesebroeck, LK MacDougall, R Stein, ...
The EMBO journal 14 (14), 3339-3348, 1995
Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit
N Miled, Y Yan, WC Hon, O Perisic, M Zvelebil, Y Inbar, ...
science 317 (5835), 239-242, 2007
Evaluation of two-dimensional differential gel electrophoresis for proteomic expression analysis of a model breast cancer cell system
S Gharbi, P Gaffney, A Yang, MJ Zvelebil, R Cramer, MD Waterfield, ...
Molecular & Cellular Proteomics 1 (2), 91-98, 2002
Cloning of a human phosphoinositide 3-kinase with a C2 domain that displays reduced sensitivity to the inhibitor wortmannin
Biochemical Journal 326 (1), 139-147, 1997
A novel point mutation in the tyrosine kinase domain of the RET proto-oncogene in sporadic medullary thyroid carcinoma and in a family with FMTC.
C Eng, DP Smith, LM Mulligan, CS Healey, MJ Zvelebil, TJ Stonehouse, ...
Oncogene 10 (3), 509-513, 1995
iASPP preferentially binds p53 proline-rich region and modulates apoptotic function of codon 72–polymorphic p53
D Bergamaschi, Y Samuels, A Sullivan, M Zvelebil, H Breyssens, A Bisso, ...
Nature genetics 38 (10), 1133-1141, 2006
Phosphatidylinositol 3-kinase is required for the expression but not for the induction or the maintenance of long-term potentiation in the hippocampal CA1 region
PP Sanna, M Cammalleri, F Berton, C Simpson, R Lutjens, FE Bloom, ...
Journal of Neuroscience 22 (9), 3359-3365, 2002
IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-κB as well as cell survival and oncogenesis
M Gyrd-Hansen, M Darding, M Miasari, MM Santoro, L Zender, W Xue, ...
Nature cell biology 10 (11), 1309-1317, 2008
Proteomic definition of normal human luminal and myoepithelial breast cells purified from reduction mammoplasties
MJ Page, B Amess, RR Townsend, R Parekh, A Herath, L Brusten, ...
Proceedings of the National Academy of Sciences 96 (22), 12589-12594, 1999
Identification of a disease-defining gene fusion in epithelioid hemangioendothelioma
MR Tanas, A Sboner, AM Oliveira, MR Erickson-Johnson, J Hespelt, ...
Science translational medicine 3 (98), 98ra82-98ra82, 2011
Phosphorylation regulates tau interactions with Src homology 3 domains of phosphatidylinositol 3-kinase, phospholipase Cγ1, Grb2, and Src family kinases
CH Reynolds, CJ Garwood, S Wray, C Price, S Kellie, T Perera, ...
Journal of Biological Chemistry 283 (26), 18177-18186, 2008
Understanding bioinformatics
MJ Zvelebil, JO Baum
Garland Science, 2007
Perforin is activated by a proteolytic cleavage during biosynthesis which reveals a phospholipid‐binding C2 domain
R Uellner, MJ Zvelebil, J Hopkins, J Jones, LK MacDougall, BP Morgan, ...
The EMBO journal 16 (24), 7287-7296, 1997
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