|A systematic survey identifies prions and illuminates sequence features of prionogenic proteins|
S Alberti, R Halfmann, O King, A Kapila, S Lindquist
Cell 137 (1), 146-158, 2009
|Prion-like polymerization underlies signal transduction in antiviral immune defense and inflammasome activation|
X Cai, J Chen, H Xu, S Liu, QX Jiang, R Halfmann, ZJ Chen
Cell 156 (6), 1207-1222, 2014
|Prions are a common mechanism for phenotypic inheritance in wild yeasts|
R Halfmann, DF Jarosz, SK Jones, A Chang, AK Lancaster, S Lindquist
Nature 482 (7385), 363-368, 2012
|Epigenetics in the extreme: prions and the inheritance of environmentally acquired traits|
R Halfmann, S Lindquist
Science 330 (6004), 629-632, 2010
|Prions, protein homeostasis, and phenotypic diversity|
R Halfmann, S Alberti, S Lindquist
Trends in cell biology 20 (3), 125-133, 2010
|Chaperone-dependent amyloid assembly protects cells from prion toxicity|
PM Douglas, S Treusch, HY Ren, R Halfmann, ML Duennwald, ...
Proceedings of the National Academy of Sciences 105 (20), 7206-7211, 2008
|Opposing effects of glutamine and asparagine govern prion formation by intrinsically disordered proteins|
R Halfmann, S Alberti, R Krishnan, N Lyle, CW O'Donnell, OD King, ...
Molecular cell 43 (1), 72-84, 2011
|Screening for amyloid aggregation by semi-denaturing detergent-agarose gel electrophoresis|
R Halfmann, S Lindquist
J Vis Exp 17, 2008
|Heritable remodeling of yeast multicellularity by an environmentally responsive prion|
DL Holmes, AK Lancaster, S Lindquist, R Halfmann
Cell 153 (1), 153-165, 2013
|Small-molecule activation of the TRAIL receptor DR5 in human cancer cells|
G Wang, X Wang, H Yu, S Wei, N Williams, DL Holmes, R Halfmann, ...
Nature chemical biology 9 (2), 84-89, 2013
|Prion formation by a yeast GLFG nucleoporin|
R Halfmann, JR Wright, S Alberti, S Lindquist, M Rexach
Prion 6 (4), 391-399, 2012
|Biochemical, cell biological, and genetic assays to analyze amyloid and prion aggregation in yeast|
S Alberti, R Halfmann, S Lindquist
Methods in enzymology 470, 709-734, 2010
|A method for probing the mutational landscape of amyloid structure|
CW O'Donnell, J Waldispühl, M Lis, R Halfmann, S Devadas, S Lindquist, ...
Bioinformatics 27 (13), i34-i42, 2011
|Quantifying nucleation in vivo reveals the physical basis of prion-like phase behavior|
T Khan, TS Kandola, J Wu, S Venkatesan, E Ketter, JJ Lange, AR Gama, ...
Molecular cell 71 (1), 155-168. e7, 2018
|A glass menagerie of low complexity sequences.|
Current Opinion in Structural Biology 38, 9-16, 2016
|A self-perpetuating repressive state of a viral replication protein blocks superinfection by the same virus|
XF Zhang, R Sun, Q Guo, S Zhang, T Meulia, R Halfmann, D Li, F Qu
PLoS pathogens 13 (3), e1006253, 2017
|Structures of autoinhibited and polymerized forms of CARD9 reveal mechanisms of CARD9 and CARD11 activation|
MJ Holliday, A Witt, AR Gama, BT Walters, CP Arthur, R Halfmann, ...
Nature communications 10 (1), 1-17, 2019
|Thermal green protein, an extremely stable, nonaggregating fluorescent protein created by structure‐guided surface engineering|
DW Close, CD Paul, PS Langan, MCJ Wilce, DAK Traore, R Halfmann, ...
Proteins: Structure, Function, and Bioinformatics 83 (7), 1225-1237, 2015
|The wtf4 meiotic driver utilizes controlled protein aggregation to generate selective cell death|
NL Nuckolls, AC Mok, JJ Lange, K Yi, TS Kandola, AM Hunn, ...
Elife 9, e55694, 2020
|Detecting and characterizing protein self-assembly in vivo by flow cytometry|
S Venkatesan, TS Kandola, A Rodríguez-Gama, A Box, R Halfmann
JoVE (Journal of Visualized Experiments), e59577, 2019