| Development of serine protease inhibitors displaying a multicentered short (< 2.3 Å) hydrogen bond binding mode: Inhibitors of urokinase-type plasminogen activator and factor Xa E Verner, BA Katz, JR Spencer, D Allen, J Hataye, W Hruzewicz, HC Hui, ... Journal of medicinal chemistry 44 (17), 2753-2771, 2001 | 160 | 2001 |
| Palladium-catalyzed stille couplings of aryl-, vinyl-, and alkyltrichlorostannanes in aqueous solution R Rai, KB Aubrecht, DB Collum Tetrahedron letters 36 (18), 3111-3114, 1995 | 111 | 1995 |
| Reductions and radical cyclizations of aryl and alkyl bromides mediated by NaBH4 in aqueous base R Rai, DB Collum Tetrahedron letters 35 (34), 6221-6224, 1994 | 96 | 1994 |
| A novel serine protease inhibition motif involving a multi-centered short hydrogen bonding network at the active site BA Katz, K Elrod, C Luong, MJ Rice, RL Mackman, PA Sprengeler, ... Journal of molecular biology 307 (5), 1451-1486, 2001 | 87 | 2001 |
| New opportunities in anti-hepatitis C virus drug discovery: targeting NS4B R Rai, J Deval Antiviral research 90 (2), 93-101, 2011 | 73 | 2011 |
| Perspectives on factor Xa inhibition R Rai, PA Sprengeler, KC Elrod, WB Young Current medicinal chemistry 8 (2), 101-119, 2001 | 73 | 2001 |
| (Hetero) aryl-bicyclic heteroaryl derivatives, their preparation and their use as protease inhibitors DA Allen, JM Hataye, WN Hruzewicz, A Kolesnikov, RL Mackman, R Rai, ... US Patent 6,867,200, 2005 | 70 | 2005 |
| High-throughput screening of enzyme inhibitors: simultaneous determination of tight-binding inhibition constants and enzyme concentration P Kuzmič, KC Elrod, LM Cregar, S Sideris, R Rai, JW Janc Analytical biochemistry 286 (1), 45-50, 2000 | 67 | 2000 |
| Quinolones as HCV NS5B polymerase inhibitors DV Kumar, R Rai, KA Brameld, JR Somoza, R Rajagopalan, JW Janc, ... Bioorganic & medicinal chemistry letters 21 (1), 82-87, 2011 | 59 | 2011 |
| Intravitreal AAV2. COMP-Ang1 prevents neurovascular degeneration in a murine model of diabetic retinopathy JM Cahoon, RR Rai, LS Carroll, H Uehara, X Zhang, CL O’Neil, ... Diabetes 64 (12), 4247-4259, 2015 | 56 | 2015 |
| Optimization of a screening lead for factor VIIa/TF WB Young, A Kolesnikov, R Rai, PA Sprengeler, EM Leahy, WD Shrader, ... Bioorganic & medicinal chemistry letters 11 (17), 2253-2256, 2001 | 56 | 2001 |
| Guanidinophenyl-substituted enol lactones as selective, mechanism-based inhibitors of trypsin-like serine proteases R Rai, JA Katzenellenbogen Journal of medicinal chemistry 35 (22), 4150-4159, 1992 | 54 | 1992 |
| Imidazo[1,2-a]pyridines That Directly Interact with Hepatitis C NS4B: Initial Preclinical Characterization JB Shotwell, S Baskaran, P Chong, KL Creech, RM Crosby, H Dickson, ... ACS Medicinal Chemistry Letters 3 (7), 565-569, 2012 | 53 | 2012 |
| 2-5a analogs and their methods of use L Beigelman, L Blatt, H Lönnberg, R Rai, G Wang, T Horn, J Symons, ... US Patent App. 12/822,088, 2010 | 46 | 2010 |
| Certain nitrogen containing bicyclic chemical entities for treating viral infections FU Schmitz, VWF Tai, R Rai, CD Roberts, ADM Abadi, S Baskaran, ... US Patent App. 12/228,139, 2009 | 46 | 2009 |
| Factor VIIa inhibitors: chemical optimization, preclinical pharmacokinetics, pharmacodynamics, and efficacy in an arterial baboon thrombosis model WB Young, J Mordenti, S Torkelson, WD Shrader, A Kolesnikov, R Rai, ... Bioorganic & medicinal chemistry letters 16 (7), 2037-2041, 2006 | 41 | 2006 |
| Certain Nitrogen Containing Bicyclic Chemical Entities for Treating Viral Infections S Baskaran, J Maung, ML Neitzel, R Rai, I Slododov, VWF Tai US Patent App. 12/368,249, 2010 | 29 | 2010 |
| Discovery of novel heterocyclic factor VIIa inhibitors R Rai, A Kolesnikov, PA Sprengeler, S Torkelson, T Ton, BA Katz, C Yu, ... Bioorganic & medicinal chemistry letters 16 (8), 2270-2273, 2006 | 28 | 2006 |
| Discovery of novel hydroxy pyrazole based factor IXa inhibitor D Vijaykumar, PA Sprengeler, M Shaghafi, JR Spencer, BA Katz, C Yu, ... Bioorganic & medicinal chemistry letters 16 (10), 2796-2799, 2006 | 27 | 2006 |
| 3-Heterocyclyl quinolone inhibitors of the HCV NS5B polymerase DV Kumar, R Rai, KA Brameld, J Riggs, JR Somoza, R Rajagopalan, ... Bioorganic & medicinal chemistry letters 22 (1), 300-304, 2012 | 26 | 2012 |
