Gunasekaran (Guna) Kannan
Gunasekaran (Guna) Kannan
Head of Biotherapeutics, Denali Therapeutics Inc.
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Is allostery an intrinsic property of all dynamic proteins?
K Gunasekaran, B Ma, R Nussinov
Proteins: Structure, Function, and Bioinformatics 57 (3), 433-443, 2004
Extended disordered proteins: targeting function with less scaffold
K Gunasekaran, CJ Tsai, S Kumar, D Zanuy, R Nussinov
Trends in biochemical sciences 28 (2), 81-85, 2003
Enhancing antibody Fc heterodimer formation through electrostatic steering effects: applications to bispecific molecules and monovalent IgG
K Gunasekaran, M Pentony, M Shen, L Garrett, C Forte, A Woodward, ...
Journal of Biological Chemistry 285 (25), 19637-19646, 2010
Beta-hairpins in proteins revisited: lessons for de novo design.
K Gunasekaran, C Ramakrishnan, P Balaram
Protein engineering 10 (10), 1131-1141, 1997
Analysis of ordered and disordered protein complexes reveals structural features discriminating between stable and unstable monomers
K Gunasekaran, CJ Tsai, R Nussinov
Journal of molecular biology 341 (5), 1327-1341, 2004
Method for making antibody Fc-heterodimeric molecules using electrostatic steering effects
G Kannan, M Wittekind, W Yan, M Pentony
US Patent 8,592,562, 2013
Stereochemical punctuation marks in protein structures: glycine and proline containing helix stop signals
K Gunasekaran, HA Nagarajaram, C Ramakrishnan, P Balaram
Journal of molecular biology 275 (5), 917-932, 1998
How different are structurally flexible and rigid binding sites? Sequence and structural features discriminating proteins that do and do not undergo conformational change upon …
K Gunasekaran, R Nussinov
Journal of molecular biology 365 (1), 257-273, 2007
Disallowed Ramachandran conformations of amino acid residues in protein structures
K Gunasekaran, C Ramakrishnan, P Balaram
Journal of molecular biology 264 (1), 191-198, 1996
A bispecific antibody targeting sclerostin and DKK-1 promotes bone mass accrual and fracture repair
M Florio, K Gunasekaran, M Stolina, X Li, L Liu, B Tipton, ...
Nature communications 7 (1), 1-14, 2016
Protein–protein interactions: organization, cooperativity and mapping in a bottom-up Systems Biology approach
O Keskin, B Ma, K Rogale, K Gunasekaran, R Nussinov
Physical biology 2 (2), S24, 2005
Keeping it in the family: folding studies of related proteins
K Gunasekaran, SJ Eyles, AT Hagler, LM Gierasch
Current opinion in structural biology 11 (1), 83-93, 2001
Energy landscape of amyloidogenic peptide oligomerization by parallel-tempering molecular dynamics simulation: significant role of Asn ladder
HHG Tsai, M Reches, CJ Tsai, K Gunasekaran, E Gazit, R Nussinov
Proceedings of the National Academy of Sciences 102 (23), 8174-8179, 2005
Conformational interconversions in peptide β-turns: analysis of turns in proteins and computational estimates of barriers
K Gunasekaran, L Gomathi, C Ramakrishnan, J Chandrasekhar, ...
Journal of molecular biology 284 (5), 1505-1516, 1998
A novel antibody engineering strategy for making monovalent bispecific heterodimeric IgG antibodies by electrostatic steering mechanism
Z Liu, EC Leng, K Gunasekaran, M Pentony, M Shen, M Howard, J Stoops, ...
Journal of Biological Chemistry 290 (12), 7535-7562, 2015
Computational study of the fibril organization of polyglutamine repeats reveals a common motif identified in β-helices
D Zanuy, K Gunasekaran, AM Lesk, R Nussinov
Journal of molecular biology 358 (1), 330-345, 2006
Method for detecting cytosine methylation in DNA samples
A Olek, K Berlin
US Patent 7,524,629, 2009
Heterodimeric immunoglobulins
G Kannan, M Florio, Z Liu, W Yan
US Patent 10,233,237, 2019
Triggering loops and enzyme function: identification of loops that trigger and modulate movements
K Gunasekaran, B Ma, R Nussinov
Journal of molecular biology 332 (1), 143-159, 2003
The stability and dynamics of the human calcitonin amyloid peptide DFNKF
HHG Tsai, D Zanuy, N Haspel, K Gunasekaran, B Ma, CJ Tsai, ...
Biophysical journal 87 (1), 146-158, 2004
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