Gunasekaran (Guna) Kannan
Gunasekaran (Guna) Kannan
Head of Biotherapeutics, Denali Therapeutics Inc.
Verified email at dnli.com
Title
Cited by
Cited by
Year
Is allostery an intrinsic property of all dynamic proteins?
K Gunasekaran, B Ma, R Nussinov
Proteins: Structure, Function, and Bioinformatics 57 (3), 433-443, 2004
8462004
Extended disordered proteins: targeting function with less scaffold
K Gunasekaran, CJ Tsai, S Kumar, D Zanuy, R Nussinov
Trends in biochemical sciences 28 (2), 81-85, 2003
3732003
Enhancing antibody Fc heterodimer formation through electrostatic steering effects: applications to bispecific molecules and monovalent IgG
K Gunasekaran, M Pentony, M Shen, L Garrett, C Forte, A Woodward, ...
Journal of Biological Chemistry 285 (25), 19637-19646, 2010
2782010
Beta-hairpins in proteins revisited: lessons for de novo design.
K Gunasekaran, C Ramakrishnan, P Balaram
Protein engineering 10 (10), 1131-1141, 1997
1991997
Analysis of ordered and disordered protein complexes reveals structural features discriminating between stable and unstable monomers
K Gunasekaran, CJ Tsai, R Nussinov
Journal of molecular biology 341 (5), 1327-1341, 2004
1772004
Method for making antibody Fc-heterodimeric molecules using electrostatic steering effects
G Kannan, M Wittekind, W Yan, M Pentony
US Patent 8,592,562, 2013
1682013
Stereochemical punctuation marks in protein structures: glycine and proline containing helix stop signals
K Gunasekaran, HA Nagarajaram, C Ramakrishnan, P Balaram
Journal of molecular biology 275 (5), 917-932, 1998
1511998
How different are structurally flexible and rigid binding sites? Sequence and structural features discriminating proteins that do and do not undergo conformational change upon …
K Gunasekaran, R Nussinov
Journal of molecular biology 365 (1), 257-273, 2007
1422007
Disallowed Ramachandran conformations of amino acid residues in protein structures
K Gunasekaran, C Ramakrishnan, P Balaram
Journal of molecular biology 264 (1), 191-198, 1996
1391996
A bispecific antibody targeting sclerostin and DKK-1 promotes bone mass accrual and fracture repair
M Florio, K Gunasekaran, M Stolina, X Li, L Liu, B Tipton, ...
Nature communications 7 (1), 1-14, 2016
1372016
Protein–protein interactions: organization, cooperativity and mapping in a bottom-up Systems Biology approach
O Keskin, B Ma, K Rogale, K Gunasekaran, R Nussinov
Physical biology 2 (2), S24, 2005
1292005
Keeping it in the family: folding studies of related proteins
K Gunasekaran, SJ Eyles, AT Hagler, LM Gierasch
Current opinion in structural biology 11 (1), 83-93, 2001
1272001
Energy landscape of amyloidogenic peptide oligomerization by parallel-tempering molecular dynamics simulation: significant role of Asn ladder
HHG Tsai, M Reches, CJ Tsai, K Gunasekaran, E Gazit, R Nussinov
Proceedings of the National Academy of Sciences 102 (23), 8174-8179, 2005
1232005
Conformational interconversions in peptide β-turns: analysis of turns in proteins and computational estimates of barriers
K Gunasekaran, L Gomathi, C Ramakrishnan, J Chandrasekhar, ...
Journal of molecular biology 284 (5), 1505-1516, 1998
991998
A novel antibody engineering strategy for making monovalent bispecific heterodimeric IgG antibodies by electrostatic steering mechanism
Z Liu, EC Leng, K Gunasekaran, M Pentony, M Shen, M Howard, J Stoops, ...
Journal of Biological Chemistry 290 (12), 7535-7562, 2015
612015
Computational study of the fibril organization of polyglutamine repeats reveals a common motif identified in β-helices
D Zanuy, K Gunasekaran, AM Lesk, R Nussinov
Journal of molecular biology 358 (1), 330-345, 2006
612006
Method for detecting cytosine methylation in DNA samples
A Olek, K Berlin
US Patent 7,524,629, 2009
592009
Heterodimeric immunoglobulins
G Kannan, M Florio, Z Liu, W Yan
US Patent 10,233,237, 2019
52*2019
Triggering loops and enzyme function: identification of loops that trigger and modulate movements
K Gunasekaran, B Ma, R Nussinov
Journal of molecular biology 332 (1), 143-159, 2003
492003
The stability and dynamics of the human calcitonin amyloid peptide DFNKF
HHG Tsai, D Zanuy, N Haspel, K Gunasekaran, B Ma, CJ Tsai, ...
Biophysical journal 87 (1), 146-158, 2004
472004
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