Atilla Akdemir
Atilla Akdemir
Bezmialem Vakif University, Faculty of Pharmacy, Department of Pharmacology
Verified email at bezmialem.edu.tr
Title
Cited by
Cited by
Year
Use of acetylcholine binding protein in the search for novel α7 nicotinic receptor ligands. In silico docking, pharmacological screening, and X-ray analysis
C Ulens, A Akdemir, A Jongejan, R van Elk, S Bertrand, A Perrakis, ...
Journal of medicinal chemistry 52 (8), 2372-2383, 2009
1092009
Fragment growing induces conformational changes in acetylcholine-binding protein: a structural and thermodynamic analysis
E Edink, P Rucktooa, K Retra, A Akdemir, T Nahar, O Zuiderveld, ...
Journal of the American Chemical Society 133 (14), 5363-5371, 2011
962011
Xanthates and trithiocarbonates strongly inhibit carbonic anhydrases and show antiglaucoma effects in vivo
F Carta, A Akdemir, A Scozzafava, E Masini, CT Supuran
Journal of medicinal chemistry 56 (11), 4691-4700, 2013
892013
The extremo-α-carbonic anhydrase (CA) from Sulfurihydrogenibium azorense, the fastest CA known, is highly activated by amino acids and amines
A Akdemir, D Vullo, V De Luca, A Scozzafava, V Carginale, M Rossi, ...
Bioorganic & medicinal chemistry letters 23 (4), 1087-1090, 2013
502013
A Class of Sulfonamides with Strong Inhibitory Action against the α-Carbonic Anhydrase from Trypanosoma cruzi
O Guzel-Akdemir, A Akdemir, P Pan, AB Vermelho, S Parkkila, ...
Journal of medicinal chemistry 56 (14), 5773-5781, 2013
472013
Discovery of novel isatin-based sulfonamides with potent and selective inhibition of the tumor-associated carbonic anhydrase isoforms IX and XII
Ö Güzel-Akdemir, A Akdemir, N Karalı, CT Supuran
Organic & biomolecular chemistry 13 (23), 6493-6499, 2015
452015
A novel library of saccharin and acesulfame derivatives as potent and selective inhibitors of carbonic anhydrase IX and XII isoforms
S Carradori, D Secci, C De Monte, A Mollica, M Ceruso, A Akdemir, ...
Bioorganic & medicinal chemistry 24 (5), 1095-1105, 2016
402016
Synthesis of a new series of dithiocarbamates with effective human carbonic anhydrase inhibitory activity and antiglaucoma action
M Bozdag, F Carta, D Vullo, A Akdemir, S Isik, C Lanzi, A Scozzafava, ...
Bioorganic & medicinal chemistry 23 (10), 2368-2376, 2015
402015
Anti-Candida activity and cytotoxicity of a large library of new N-substituted-1, 3-thiazolidin-4-one derivatives
C De Monte, S Carradori, B Bizzarri, A Bolasco, F Caprara, A Mollica, ...
European journal of medicinal chemistry 107, 82-96, 2016
392016
Open saccharin-based secondary sulfonamides as potent and selective inhibitors of cancer-related carbonic anhydrase IX and XII isoforms
M D’Ascenzio, P Guglielmi, S Carradori, D Secci, R Florio, A Mollica, ...
Journal of enzyme inhibition and medicinal chemistry 32 (1), 51-59, 2017
382017
A Gq/11-coupled mutant histamine H1 receptor F435A activated solely by synthetic ligands (RASSL)
M Bruysters, A Jongejan, A Akdemir, RA Bakker, R Leurs
Journal of Biological Chemistry 280 (41), 34741-34746, 2005
382005
Exploring new Probenecid-based carbonic anhydrase inhibitors: Synthesis, biological evaluation and docking studies
A Mollica, R Costante, A Akdemir, S Carradori, A Stefanucci, ...
Bioorganic & medicinal chemistry 23 (17), 5311-5318, 2015
372015
Selective inhibition of human carbonic anhydrases by novel amide derivatives of probenecid: synthesis, biological evaluation and molecular modelling studies
M D’Ascenzio, S Carradori, D Secci, D Vullo, M Ceruso, A Akdemir, ...
Bioorganic & medicinal chemistry 22 (15), 3982-3988, 2014
372014
Computational investigation of the selectivity of salen and tetrahydrosalen compounds towards the tumor-associated hCA XII isozyme
A Akdemir, C De Monte, S Carradori, CT Supuran
Journal of enzyme inhibition and medicinal chemistry 30 (1), 114-118, 2015
362015
Carbonic anhydrase inhibitors targeting metabolism and tumor microenvironment
A Angeli, F Carta, A Nocentini, JY Winum, R Zalubovskis, A Akdemir, ...
Metabolites 10 (10), 412, 2020
352020
New amide derivatives of Probenecid as selective inhibitors of carbonic anhydrase IX and XII: biological evaluation and molecular modelling studies
S Carradori, A Mollica, M Ceruso, M D’Ascenzio, C De Monte, P Chimenti, ...
Bioorganic & medicinal chemistry 23 (13), 2975-2981, 2015
342015
Acetylcholine binding protein (AChBP) as template for hierarchical in silico screening procedures to identify structurally novel ligands for the nicotinic receptors
A Akdemir, P Rucktooa, A Jongejan, R van Elk, S Bertrand, TK Sixma, ...
Bioorganic & medicinal chemistry 19 (20), 6107-6119, 2011
332011
Synthesis of coumarin-sulfonamide derivatives and determination of their cytotoxicity, carbonic anhydrase inhibitory and molecular docking studies
BZ Kurt, F Sonmez, D Ozturk, A Akdemir, A Angeli, CT Supuran
European journal of medicinal chemistry 183, 111702, 2019
242019
o-Benzenedisulfonimido–sulfonamides are potent inhibitors of the tumor-associated carbonic anhydrase isoforms CA IX and CA XII
Ö Güzel-Akdemir, A Akdemir, S Isik, D Vullo, CT Supuran
Bioorganic & medicinal chemistry 21 (6), 1386-1391, 2013
232013
Inhibition of tumor-associated human carbonic anhydrase isozymes IX and XII by a new class of substituted-phenylacetamido aromatic sulfonamides
A Akdemir, Ö Güzel-Akdemir, A Scozzafava, C Capasso, CT Supuran
Bioorganic & medicinal chemistry 21 (17), 5228-5232, 2013
222013
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