|Use of acetylcholine binding protein in the search for novel α7 nicotinic receptor ligands. In silico docking, pharmacological screening, and X-ray analysis|
C Ulens, A Akdemir, A Jongejan, R van Elk, S Bertrand, A Perrakis, ...
Journal of medicinal chemistry 52 (8), 2372-2383, 2009
|Fragment growing induces conformational changes in acetylcholine-binding protein: a structural and thermodynamic analysis|
E Edink, P Rucktooa, K Retra, A Akdemir, T Nahar, O Zuiderveld, ...
Journal of the American Chemical Society 133 (14), 5363-5371, 2011
|Xanthates and trithiocarbonates strongly inhibit carbonic anhydrases and show antiglaucoma effects in vivo|
F Carta, A Akdemir, A Scozzafava, E Masini, CT Supuran
Journal of medicinal chemistry 56 (11), 4691-4700, 2013
|The extremo-α-carbonic anhydrase (CA) from Sulfurihydrogenibium azorense, the fastest CA known, is highly activated by amino acids and amines|
A Akdemir, D Vullo, V De Luca, A Scozzafava, V Carginale, M Rossi, ...
Bioorganic & medicinal chemistry letters 23 (4), 1087-1090, 2013
|A Class of Sulfonamides with Strong Inhibitory Action against the α-Carbonic Anhydrase from Trypanosoma cruzi|
O Guzel-Akdemir, A Akdemir, P Pan, AB Vermelho, S Parkkila, ...
Journal of medicinal chemistry 56 (14), 5773-5781, 2013
|Discovery of novel isatin-based sulfonamides with potent and selective inhibition of the tumor-associated carbonic anhydrase isoforms IX and XII|
Ö Güzel-Akdemir, A Akdemir, N Karalı, CT Supuran
Organic & biomolecular chemistry 13 (23), 6493-6499, 2015
|A novel library of saccharin and acesulfame derivatives as potent and selective inhibitors of carbonic anhydrase IX and XII isoforms|
S Carradori, D Secci, C De Monte, A Mollica, M Ceruso, A Akdemir, ...
Bioorganic & medicinal chemistry 24 (5), 1095-1105, 2016
|Synthesis of a new series of dithiocarbamates with effective human carbonic anhydrase inhibitory activity and antiglaucoma action|
M Bozdag, F Carta, D Vullo, A Akdemir, S Isik, C Lanzi, A Scozzafava, ...
Bioorganic & medicinal chemistry 23 (10), 2368-2376, 2015
|Anti-Candida activity and cytotoxicity of a large library of new N-substituted-1, 3-thiazolidin-4-one derivatives|
C De Monte, S Carradori, B Bizzarri, A Bolasco, F Caprara, A Mollica, ...
European journal of medicinal chemistry 107, 82-96, 2016
|Open saccharin-based secondary sulfonamides as potent and selective inhibitors of cancer-related carbonic anhydrase IX and XII isoforms|
M D’Ascenzio, P Guglielmi, S Carradori, D Secci, R Florio, A Mollica, ...
Journal of enzyme inhibition and medicinal chemistry 32 (1), 51-59, 2017
|A Gq/11-coupled mutant histamine H1 receptor F435A activated solely by synthetic ligands (RASSL)|
M Bruysters, A Jongejan, A Akdemir, RA Bakker, R Leurs
Journal of Biological Chemistry 280 (41), 34741-34746, 2005
|Exploring new Probenecid-based carbonic anhydrase inhibitors: Synthesis, biological evaluation and docking studies|
A Mollica, R Costante, A Akdemir, S Carradori, A Stefanucci, ...
Bioorganic & medicinal chemistry 23 (17), 5311-5318, 2015
|Selective inhibition of human carbonic anhydrases by novel amide derivatives of probenecid: synthesis, biological evaluation and molecular modelling studies|
M D’Ascenzio, S Carradori, D Secci, D Vullo, M Ceruso, A Akdemir, ...
Bioorganic & medicinal chemistry 22 (15), 3982-3988, 2014
|Computational investigation of the selectivity of salen and tetrahydrosalen compounds towards the tumor-associated hCA XII isozyme|
A Akdemir, C De Monte, S Carradori, CT Supuran
Journal of enzyme inhibition and medicinal chemistry 30 (1), 114-118, 2015
|Carbonic anhydrase inhibitors targeting metabolism and tumor microenvironment|
A Angeli, F Carta, A Nocentini, JY Winum, R Zalubovskis, A Akdemir, ...
Metabolites 10 (10), 412, 2020
|New amide derivatives of Probenecid as selective inhibitors of carbonic anhydrase IX and XII: biological evaluation and molecular modelling studies|
S Carradori, A Mollica, M Ceruso, M D’Ascenzio, C De Monte, P Chimenti, ...
Bioorganic & medicinal chemistry 23 (13), 2975-2981, 2015
|Acetylcholine binding protein (AChBP) as template for hierarchical in silico screening procedures to identify structurally novel ligands for the nicotinic receptors|
A Akdemir, P Rucktooa, A Jongejan, R van Elk, S Bertrand, TK Sixma, ...
Bioorganic & medicinal chemistry 19 (20), 6107-6119, 2011
|Synthesis of coumarin-sulfonamide derivatives and determination of their cytotoxicity, carbonic anhydrase inhibitory and molecular docking studies|
BZ Kurt, F Sonmez, D Ozturk, A Akdemir, A Angeli, CT Supuran
European journal of medicinal chemistry 183, 111702, 2019
|o-Benzenedisulfonimido–sulfonamides are potent inhibitors of the tumor-associated carbonic anhydrase isoforms CA IX and CA XII|
Ö Güzel-Akdemir, A Akdemir, S Isik, D Vullo, CT Supuran
Bioorganic & medicinal chemistry 21 (6), 1386-1391, 2013
|Inhibition of tumor-associated human carbonic anhydrase isozymes IX and XII by a new class of substituted-phenylacetamido aromatic sulfonamides|
A Akdemir, Ö Güzel-Akdemir, A Scozzafava, C Capasso, CT Supuran
Bioorganic & medicinal chemistry 21 (17), 5228-5232, 2013