ashraf brik
ashraf brik
Professor of Chemistry
technion.ac.il üzerinde doğrulanmış e-posta adresine sahip - Ana Sayfa
Başlık
Alıntı yapanlar
Alıntı yapanlar
Yıl
HIV-1 protease: mechanism and drug discovery
A Brik, CH Wong
Organic & biomolecular chemistry 1 (1), 5-14, 2003
5302003
Small molecules targeting severe acute respiratory syndrome human coronavirus
CY Wu, JT Jan, SH Ma, CJ Kuo, HF Juan, YSE Cheng, HH Hsu, ...
Proceedings of the National Academy of Sciences 101 (27), 10012-10017, 2004
4112004
1, 2, 3‐Triazole as a peptide surrogate in the rapid synthesis of HIV‐1 protease inhibitors
A Brik, J Alexandratos, YC Lin, JH Elder, AJ Olson, A Wlodawer, ...
ChemBioChem 6 (7), 1167-1169, 2005
3322005
Highly efficient and chemoselective peptide ubiquitylation
KS Ajish Kumar, M Haj‐Yahya, D Olschewski, HA Lashuel, A Brik
Angewandte Chemie 121 (43), 8234-8238, 2009
2322009
A copper (I)-catalyzed 1, 2, 3-triazole azide− alkyne click compound is a potent inhibitor of a multidrug-resistant HIV-1 protease variant
MJ Giffin, H Heaslet, A Brik, YC Lin, G Cauvi, CH Wong, DE McRee, ...
Journal of medicinal chemistry 51 (20), 6263-6270, 2008
2222008
Expanding the chemical toolbox for the synthesis of large and uniquely modified proteins
S Bondalapati, M Jbara, A Brik
Nature chemistry 8 (5), 407-418, 2016
2192016
Total chemical synthesis of a 304 amino acid K48‐linked tetraubiquitin protein
KSA Kumar, SN Bavikar, L Spasser, T Moyal, S Ohayon, A Brik
Angewandte Chemie 123 (27), 6261-6265, 2011
2022011
Rapid diversity‐oriented synthesis in microtiter plates for in situ screening of HIV protease inhibitors
A Brik, J Muldoon, YC Lin, JH Elder, DS Goodsell, AJ Olson, VV Fokin, ...
ChemBioChem 4 (11), 1246-1248, 2003
1842003
RNF20 and USP44 regulate stem cell differentiation by modulating H2B monoubiquitylation
G Fuchs, E Shema, R Vesterman, E Kotler, Z Wolchinsky, S Wilder, ...
Molecular cell 46 (5), 662-673, 2012
1642012
Structural basis for histone H2B deubiquitination by the SAGA DUB module
MT Morgan, M Haj-Yahya, AE Ringel, P Bandi, A Brik, C Wolberger
Science 351 (6274), 725-728, 2016
1582016
Total chemical synthesis of di‐ubiquitin chains
KSA Kumar, L Spasser, LA Erlich, SN Bavikar, A Brik
Angewandte Chemie 122 (48), 9312-9317, 2010
1562010
The size of the proteasomal substrate determines whether its degradation will be mediated by mono-or polyubiquitylation
N Shabek, Y Herman-Bachinsky, S Buchsbaum, O Lewinson, ...
Molecular cell 48 (1), 87-97, 2012
1472012
Protein synthesis assisted by native chemical ligation at leucine
Z Harpaz, P Siman, KSA Kumar, A Brik
ChemBioChem 11 (9), 1232-1235, 2010
1472010
Sugar-assisted glycopeptide ligation
A Brik, YY Yang, S Ficht, CH Wong
Journal of the American Chemical Society 128 (17), 5626-5627, 2006
1392006
Chemistry and biology of the ubiquitin signal
L Spasser, A Brik
Angewandte Chemie International Edition 51 (28), 6840-6862, 2012
1312012
Convergent chemical synthesis of histone H2B protein for the site‐specific ubiquitination at Lys34
P Siman, SV Karthikeyan, M Nikolov, W Fischle, A Brik
Angewandte Chemie 125 (31), 8217-8221, 2013
1222013
Sugar-assisted ligation in glycoprotein synthesis
YY Yang, S Ficht, A Brik, CH Wong
Journal of the American Chemical Society 129 (24), 7690-7701, 2007
1192007
Towards Elucidation of the Role of Ubiquitination in the Pathogenesis of Parkinson’s Disease with Semisynthetic Ubiquitinated α‐Synuclein
M Hejjaoui, M Haj‐Yahya, KSA Kumar, A Brik, HA Lashuel
Angewandte Chemie International Edition 50 (2), 405-409, 2011
1062011
Native chemical ligation at glutamine
P Siman, SV Karthikeyan, A Brik
Organic letters 14 (6), 1520-1523, 2012
1052012
Synthetic polyubiquitinated α-Synuclein reveals important insights into the roles of the ubiquitin chain in regulating its pathophysiology
M Haj-Yahya, B Fauvet, Y Herman-Bachinsky, M Hejjaoui, SN Bavikar, ...
Proceedings of the National Academy of Sciences 110 (44), 17726-17731, 2013
1042013
Sistem, işlemi şu anda gerçekleştiremiyor. Daha sonra yeniden deneyin.
Makaleler 1–20