Dr. Björn Over
Dr. Björn Over
Rhein-Chemotechnik GmbH
rhein-chemotechnik.com üzerinde doğrulanmış e-posta adresine sahip - Ana Sayfa
Başlık
Alıntı yapanlar
Alıntı yapanlar
Yıl
Oral druggable space beyond the rule of 5: insights from drugs and clinical candidates
BC Doak, B Over, F Giordanetto, J Kihlberg
Chemistry & biology 21 (9), 1115-1142, 2014
3542014
Natural-product-derived fragments for fragment-based ligand discovery
B Over, S Wetzel, C Grütter, Y Nakai, S Renner, D Rauh, H Waldmann
Nature chemistry 5 (1), 21-28, 2013
2492013
Cell permeability beyond the rule of 5
P Matsson, BC Doak, B Over, J Kihlberg
Advanced drug delivery reviews 101, 42-61, 2016
1402016
Structural and conformational determinants of macrocycle cell permeability
B Over, P Matsson, C Tyrchan, P Artursson, BC Doak, MA Foley, ...
Nature chemical biology 12 (12), 1065-1074, 2016
1082016
Impact of dynamically exposed polarity on permeability and solubility of chameleonic drugs beyond the rule of 5
M Rossi Sebastiano, BC Doak, M Backlund, V Poongavanam, B Over, ...
Journal of medicinal chemistry 61 (9), 4189-4202, 2018
892018
Impact of stereospecific intramolecular hydrogen bonding on cell permeability and physicochemical properties
B Over, P McCarren, P Artursson, M Foley, F Giordanetto, G Grönberg, ...
Journal of medicinal chemistry 57 (6), 2746-2754, 2014
712014
Identification and further development of thiazolidinones spiro-fused to indolin-2-ones as potent and selective inhibitors of Mycobacterium tuberculosis protein tyrosine …
VV Vintonyak, K Warburg, B Over, K Hübel, D Rauh, H Waldmann
Tetrahedron 67 (35), 6713-6729, 2011
522011
Fragment‐Based Lead Discovery: Screening and Optimizing Fragments for Thermolysin Inhibition
L Englert, K Silber, H Steuber, S Brass, B Over, HD Gerber, A Heine, ...
ChemMedChem: Chemistry Enabling Drug Discovery 5 (6), 930-940, 2010
302010
Natural-product-derived fragments for fragment-based ligand discovery Nat
B Over, S Wetzel, C Grütter, Y Nakai, S Renner, D Rauh, H Waldmann
Chem 5, 21-28, 2013
82013
Mining natural products for macrocycles to drug difficult targets
F Begnini, V Poongavanam, B Over, M Castaldo, S Geschwindner, ...
Journal of medicinal chemistry 64 (2), 1054-1072, 2020
42020
Full wwPDB X-ray Structure Validation Report i
B Mikami, W Hashimoto, K Murata
1
Erratum: Structural and Conformational Determinants of Macrocycle Cell Permeability
B Over, P Matsson, C Tyrchan, P Artursson, BC Doak, MA Foley, ...
Nature chemical biology 13 (8), 922, 2017
2017
How to design cell permeable non-peptidic macrocycles
B Over, P Matsson, C Tyrchan, P Artursson, B Doak, M Foley, ...
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 251, 2016
2016
Macrocyclic drugs and clinical candidates-what are the limits of oral bioavailability?
B Doak, B Over, F Giordanetto, J Kihlberg
Abstracts of Papers of the American Chemical Society 248, 2014
2014
Chemoinformatische Entwicklung von Naturstofffragmenten, sowie deren strukturbiologische und biochemische Evaluierung zur fragmentbasierten Inhibitorentwicklung
B Over
Universitätsbibliothek Dortmund, 2013
2013
Synthese von Thermolysininhibitoren unter Verwendung eines fragmentbasierten Ansatzes zur Wirkstoffentwicklung
B Over
2008
Extent of oral druggable space beyond the rule of 5: Learnings from drugs and clinical candidates
BC Doak, B Over, F Giordanetto, J Kihlberg
Chemistry & Biology, 0
Sistem, işlemi şu anda gerçekleştiremiyor. Daha sonra yeniden deneyin.
Makaleler 1–17