Aykut Uren
Aykut Uren
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Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action
PW Finch, X He, MJ Kelley, A Üren, RP Schaudies, NC Popescu, ...
Proceedings of the National Academy of Sciences 94 (13), 6770-6775, 1997
Secreted frizzled-related protein-1 binds directly to Wingless and is a biphasic modulator of Wnt signaling
A Uren, F Reichsman, V Anest, WG Taylor, K Muraiso, DP Bottaro, ...
Journal of Biological Chemistry 275 (6), 4374-4382, 2000
A small molecule blocking oncogenic protein EWS-FLI1 interaction with RNA helicase A inhibits growth of Ewing's sarcoma
HV Erkizan, Y Kong, M Merchant, S Schlottmann, JS Barber-Rotenberg, ...
Nature medicine 15 (7), 750-756, 2009
Arsenic trioxide inhibits human cancer cell growth and tumor development in mice by blocking Hedgehog/GLI pathway
EM Beauchamp, L Ringer, G Bulut, KP Sajwan, MD Hall, YC Lee, ...
The Journal of clinical investigation 121 (1), 148-160, 2011
Activation of the canonical Wnt pathway during genital keratinocyte transformation: a model for cervical cancer progression
A Üren, S Fallen, H Yuan, A Usubütün, T Küçükali, R Schlegel, ...
Cancer research 65 (14), 6199-6206, 2005
GLI1 is a direct transcriptional target of EWS-FLI1 oncoprotein
E Beauchamp, G Bulut, O Abaan, K Chen, A Merchant, W Matsui, Y Endo, ...
Journal of Biological Chemistry 284 (14), 9074-9082, 2009
Predicting new indications for approved drugs using a proteochemometric method
S Dakshanamurthy, NT Issa, S Assefnia, A Seshasayee, OJ Peters, ...
Journal of medicinal chemistry 55 (15), 6832-6848, 2012
Small molecule inhibitors of ezrin inhibit the invasive phenotype of osteosarcoma cells
G Bulut, SH Hong, K Chen, EM Beauchamp, S Rahim, GW Kosturko, ...
Oncogene 31 (3), 269-281, 2012
Oncoprotein EWS-FLI1 activity is enhanced by RNA helicase A
JA Toretsky, V Erkizan, A Levenson, OD Abaan, JD Parvin, TP Cripe, ...
Cancer research 66 (11), 5574-5581, 2006
Toward a drug development path that targets metastatic progression in osteosarcoma
C Khanna, TM Fan, R Gorlick, LJ Helman, ES Kleinerman, PC Adamson, ...
Clinical Cancer Research 20 (16), 4200-4209, 2014
Oncogenic fusion protein EWS-FLI1 is a network hub that regulates alternative splicing
SP Selvanathan, GT Graham, HV Erkizan, U Dirksen, TG Natarajan, ...
Proceedings of the National Academy of Sciences 112 (11), E1307-E1316, 2015
Secreted Frizzled-related proteins can regulate metanephric development
K Yoshino, JS Rubin, KG Higinbotham, A Üren, V Anest, SY Plisov, ...
Mechanisms of development 102 (1-2), 45-55, 2001
Wnt signaling promotes proliferation and stemness regulation of spermatogonial stem/progenitor cells
N Golestaneh, E Beauchamp, S Fallen, M Kokkinaki, A Üren, M Dym
Reproduction 138 (1), 151-162, 2009
Wnt-3a-dependent Cell Motility Involves RhoA Activation and Is Specifically Regulated by Dishevelled-2*[boxs]
Y Endo, V Wolf, K Muraiso, K Kamijo, L Soon, A Uren, ...
Journal of Biological Chemistry 280 (1), 777-786, 2005
Preparation of F-18 labeled annexin V: a potential PET radiopharmaceutical for imaging cell death
J Toretsky, A Levenson, IN Weinberg, JF Tait, A Üren, RC Mease
Nuclear medicine and biology 31 (6), 747-752, 2004
A global benchmark study using affinity-based biosensors
RL Rich, GA Papalia, PJ Flynn, J Furneisen, J Quinn, JS Klein, ...
Analytical biochemistry 386 (2), 194-216, 2009
Disulfide bond assignments of secreted Frizzled-related protein-1 provide insights about Frizzled homology and netrin modules
JM Chong, A Uren, JS Rubin, DW Speicher
Journal of Biological Chemistry 277 (7), 5134-5144, 2002
Keratinocyte growth factor facilitates alloengraftment and ameliorates graft-versus-host disease in mice by a mechanism independent of repair of conditioning-induced tissue injury
A Panoskaltsis-Mortari, PA Taylor, JS Rubin, A Uren, LA Welniak, ...
Blood, The Journal of the American Society of Hematology 96 (13), 4350-4356, 2000
Wnt-3a and Dickkopf-1 stimulate neurite outgrowth in Ewing tumor cells via a Frizzled3-and c-Jun N-terminal kinase-dependent mechanism
Y Endo, E Beauchamp, D Woods, WG Taylor, JA Toretsky, JS Rubin
Molecular and cellular biology, 2008
Secreted Frizzled-related protein potentiation versus inhibition of Wnt3a/β-catenin signaling
CP Xavier, M Melikova, Y Chuman, A Üren, B Baljinnyam, JS Rubin
Cellular signalling 26 (1), 94-101, 2014
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