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Yıl
Eukaryotic DNA topoisomerase IIβ
CA Austin, KL Marsh
Bioessays 20 (3), 215-226, 1998
3421998
A novel DNA-dependent protein kinase inhibitor, NU7026, potentiates the cytotoxicity of topoisomerase II poisons used in the treatment of leukemia
E Willmore, S de Caux, NJ Sunter, MJ Tilby, GH Jackson, CA Austin, ...
Blood 103 (12), 4659-4665, 2004
3322004
Different patterns of gene expression of topoisomerase II isoforms in differentiated tissues during murine development
G Capranico, S Tinelli, CA Austin, ML Fisher, F Zunino
Biochimica et Biophysica Acta (BBA)-Gene Structure and Expression 1132 (1 …, 1992
3191992
γH2AX foci form preferentially in euchromatin after ionising-radiation
IG Cowell, NJ Sunter, PB Singh, CA Austin, BW Durkacz, MJ Tilby
PloS one 2 (10), e1057, 2007
2822007
The structure of DNA-bound human topoisomerase II alpha: conformational mechanisms for coordinating inter-subunit interactions with DNA cleavage
TJ Wendorff, BH Schmidt, P Heslop, CA Austin, JM Berger
Journal of molecular biology 424 (3-4), 109-124, 2012
2472012
Digitoxin inhibits the growth of cancer cell lines at concentrations commonly found in cardiac patients
M López-Lázaro, N Pastor, SS Azrak, MJ Ayuso, CA Austin, F Cortés
Journal of natural products 68 (11), 1642-1645, 2005
2422005
Site-specific DNA cleavage by mammalian DNA topoisomerase II induced by novel flavone and catechin derivatives
CA Austin, S Patel, K Ono, H Nakane, LM Fisher
Biochemical Journal 282 (3), 883-889, 1992
2351992
Novel HeLa topoisomerase II is the IIβ isoform: complete coding sequence and homology with other type II topoisomerases
CA Austin, JH Sng, S Patel, LM Fisher
Biochimica et Biophysica Acta (BBA)-Gene Structure and Expression 1172 (3 …, 1993
2031993
Model for MLL translocations in therapy-related leukemia involving topoisomerase IIβ-mediated DNA strand breaks and gene proximity
IG Cowell, Z Sondka, K Smith, KC Lee, CM Manville, ...
Proceedings of the National Academy of Sciences 109 (23), 8989-8994, 2012
1932012
Etoposide targets topoisomerase IIα and IIβ in leukemic cells: Isoform-specific cleavable complexes visualized and quantifiedin situ by a novel immunofluorescence technique
E Willmore, AJ Frank, K Padget, MJ Tilby, CA Austin
Molecular pharmacology 54 (1), 78-85, 1998
1731998
Use of yeast in the study of anticancer drugs targeting DNA topoisomerases: expression of a functional recombinant human DNA topoisomerase IIα in yeast
RA Wasserman, CA Austin, LM Fisher, JC Wang
Cancer Research 53 (15), 3591-3596, 1993
1721993
H2AX phosphorylation as a genotoxicity endpoint
GP Watters, DJ Smart, JS Harvey, CA Austin
Mutation Research/Genetic Toxicology and Environmental Mutagenesis 679 (1-2 …, 2009
1662009
Expression, Domain Structure, and Enzymatic Properties of an Active Recombinant Human DNA Topoisomerase IIβ (∗)
CA Austin, KL Marsh, RA Wasserman, E Willmore, PJ Sayer, JC Wang, ...
Journal of Biological Chemistry 270 (26), 15739-15746, 1995
1421995
Human topoisomerases and their roles in genome stability and organization
Y Pommier, A Nussenzweig, S Takeda, C Austin
Nature Reviews Molecular Cell Biology 23 (6), 407-427, 2022
1412022
Mechanism of generation of therapy related leukemia in response to anti-topoisomerase II agents
IG Cowell, CA Austin
International journal of environmental research and public health 9 (6 …, 2012
1402012
NK314, a topoisomerase II inhibitor that specifically targets the α isoform
E Toyoda, S Kagaya, IG Cowell, A Kurosawa, K Kamoshita, K Nishikawa, ...
Journal of biological chemistry 283 (35), 23711-23720, 2008
1402008
DNA-dependent protein kinase is a therapeutic target and an indicator of poor prognosis in B-cell chronic lymphocytic leukemia
E Willmore, SL Elliott, T Mainou-Fowler, GP Summerfield, GH Jackson, ...
Clinical cancer research 14 (12), 3984-3992, 2008
1322008
Murine transgenic cells lacking DNA topoisomerase IIβ are resistant to acridines and mitoxantrone: analysis of cytotoxicity and cleavable complex formation
F Errington, E Willmore, MJ Tilby, L Li, G Li, W Li, BC Baguley, CA Austin
Molecular pharmacology 56 (6), 1309-1316, 1999
1311999
The novel poly (ADP-Ribose) polymerase inhibitor, AG14361, sensitizes cells to topoisomerase I poisons by increasing the persistence of DNA strand breaks
LM Smith, E Willmore, CA Austin, NJ Curtin
Clinical cancer research 11 (23), 8449-8457, 2005
1302005
The dietary flavonoids myricetin and fisetin act as dual inhibitors of DNA topoisomerases I and II in cells
M López-Lázaro, E Willmore, CA Austin
Mutation Research/Genetic Toxicology and Environmental Mutagenesis 696 (1 …, 2010
1262010
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